Title : Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype - Breining_2009_Bioorg.Med.Chem.Lett_19_4359 |
Author(s) : Breining SR , Bencherif M , Grady SR , Whiteaker P , Marks MJ , Wageman CR , Lester HA , Yohannes D |
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4359 , 2009 |
Abstract :
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional activity at alpha6 subunit-containing neuronal nicotinic receptors (NNRs) and decrease activation of ganglionic nicotinic receptors, depending on the scaffold. The ramifications of this structure-activity relationship are discussed in the context of the design of small molecules targeting smoking cessation. |
PubMedSearch : Breining_2009_Bioorg.Med.Chem.Lett_19_4359 |
PubMedID: 19560354 |
Breining SR, Bencherif M, Grady SR, Whiteaker P, Marks MJ, Wageman CR, Lester HA, Yohannes D (2009)
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype
Bioorganic & Medicinal Chemistry Lett
19 :4359
Breining SR, Bencherif M, Grady SR, Whiteaker P, Marks MJ, Wageman CR, Lester HA, Yohannes D (2009)
Bioorganic & Medicinal Chemistry Lett
19 :4359