Full name : Bencherif Merouane
First name : Merouane
Mail : Targacept Inc., 200 E 1st St 300, Winston-Salem, NC 27101-4165
Zip Code :
City :
Country : USA
Email : merouane.bencherif@targacept.com
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Fax :
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Comment
| Title : Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the alpha4beta2 and alpha6\/alpha3beta2beta3 nicotinic acetylcholine receptors (nAChRs) - Strachan_2014_Eur.J.Med.Chem_86C_60 |
| Author(s) : Strachan JP , Kombo DC , Mazurov A , Heemstra R , Bhatti BS , Akireddy R , Murthy S , Miao L , Jett JE , Speake J , Bencherif M |
| Ref : Eur Journal of Medicinal Chemistry , 86C :60 , 2014 |
| Abstract : |
| PubMedSearch : Strachan_2014_Eur.J.Med.Chem_86C_60 |
| PubMedID: 25147147 |
| Title : Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by alpha7 nicotinic receptor agonist - Narla_2013_Stem.Cells.Transl.Med_2_776 |
| Author(s) : Narla ST , Klejbor I , Birkaya B , Lee YW , Morys J , Stachowiak EK , Prokop D , Bencherif M , Stachowiak MK |
| Ref : Stem Cells Transl Med , 2 :776 , 2013 |
| Abstract : |
| PubMedSearch : Narla_2013_Stem.Cells.Transl.Med_2_776 |
| PubMedID: 24014683 |
| Title : Schizophrenia: a neurodevelopmental disorder--integrative genomic hypothesis and therapeutic implications from a transgenic mouse model - Stachowiak_2013_Schizophr.Res_143_367 |
| Author(s) : Stachowiak MK , Kucinski A , Curl R , Syposs C , Yang Y , Narla S , Terranova C , Prokop D , Klejbor I , Bencherif M , Birkaya B , Corso T , Parikh A , Tzanakakis ES , Wersinger S , Stachowiak EK |
| Ref : Schizophr Res , 143 :367 , 2013 |
| Abstract : |
| PubMedSearch : Stachowiak_2013_Schizophr.Res_143_367 |
| PubMedID: 23231877 |
| Title : alpha7 nicotinic receptor agonist reactivates neurogenesis in adult brain - Narla_2013_Biochem.Pharmacol_86(8)_1099 |
| Author(s) : Narla S , Klejbor I , Birkaya B , Lee YW , Morys J , Stachowiak EK , Terranova C , Bencherif M , Stachowiak MK |
| Ref : Biochemical Pharmacology , 86 :1099 , 2013 |
| Abstract : |
| PubMedSearch : Narla_2013_Biochem.Pharmacol_86(8)_1099 |
| PubMedID: 23933384 |
| Title : Validation of a high-throughput, automated electrophysiology platform for the screening of nicotinic agonists and antagonists - Graef_2013_J.Biomol.Screen_18_116 |
| Author(s) : Graef JD , Benson LC , Sidach SS , Wei H , Lippiello PM , Bencherif M , Fedorov NB |
| Ref : J Biomol Screen , 18 :116 , 2013 |
| Abstract : |
| PubMedSearch : Graef_2013_J.Biomol.Screen_18_116 |
| PubMedID: 22960782 |
| Title : Nicotinic Receptor Agonists Reduce L-DOPA-Induced Dyskinesias in a Monkey Model of Parkinson's Disease - Zhang_2013_J.Pharmacol.Exp.Ther_347_225 |
| Author(s) : Zhang D , Mallela A , Sohn D , Carroll FI , Bencherif M , Letchworth SR , Quik M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 347 :225 , 2013 |
| Abstract : |
| PubMedSearch : Zhang_2013_J.Pharmacol.Exp.Ther_347_225 |
| PubMedID: 23902940 |
| Title : Neuronal nicotinic receptor agonists ameliorate spontaneous motor asymmetries and motor discoordination in a unilateral mouse model of Parkinson's disease - Kucinski_2013_Pharmacol.Biochem.Behav_111_1 |
| Author(s) : Kucinski A , Wersinger S , Stachowiak EK , Corso TD , Parry MJ , Zhang J , Jordan K , Letchworth SR , Bencherif M , Stachowiak MK |
| Ref : Pharmacol Biochem Behav , 111 :1 , 2013 |
| Abstract : |
| PubMedSearch : Kucinski_2013_Pharmacol.Biochem.Behav_111_1 |
| PubMedID: 23872135 |
| Title : A method for bidirectional solution exchange--liquid bullet applications of acetylcholine to alpha7 nicotinic receptors - Fedorov_2012_J.Neurosci.Methods_206_23 |
| Author(s) : Fedorov N , Benson L , Graef JD , Hyman J , Sollenberger J , Pettersson F , Lippiello PM , Bencherif M |
| Ref : Journal of Neuroscience Methods , 206 :23 , 2012 |
| Abstract : |
| PubMedSearch : Fedorov_2012_J.Neurosci.Methods_206_23 |
| PubMedID: 22342972 |
| Title : Alpha7 nicotinic cholinergic neuromodulation may reconcile multiple neurotransmitter hypotheses of schizophrenia - Bencherif_2012_Med.Hypotheses_78_594 |
| Author(s) : Bencherif M , Stachowiak MK , Kucinski AJ , Lippiello PM |
| Ref : Med Hypotheses , 78 :594 , 2012 |
| Abstract : |
| PubMedSearch : Bencherif_2012_Med.Hypotheses_78_594 |
| PubMedID: 22336089 |
| Title : Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of alpha4beta2* receptors - Zhang_2012_Eur.J.Pharm.Sci_47_813 |
| Author(s) : Zhang J , Xiao YD , Jordan KG , Hammond PS , Van Dyke KM , Mazurov AA , Speake JD , Lippiello PM , James JW , Letchworth SR , Bencherif M , Hauser TA |
| Ref : Eur J Pharm Sci , 47 :813 , 2012 |
| Abstract : |
| PubMedSearch : Zhang_2012_Eur.J.Pharm.Sci_47_813 |
| PubMedID: 23036283 |
| Title : alpha7 neuronal nicotinic receptor agonist (TC-7020) reverses increased striatal dopamine release during acoustic PPI testing in a transgenic mouse model of schizophrenia - Kucinski_2012_Schizophr.Res_136_82 |
| Author(s) : Kucinski A , Syposs C , Wersinger S , Bencherif M , Stachowiak MK , Stachowiak EK |
| Ref : Schizophr Res , 136 :82 , 2012 |
| Abstract : |
| PubMedSearch : Kucinski_2012_Schizophr.Res_136_82 |
| PubMedID: 22285656 |
| Title : Poster: Novel properties of neuronal nicotinic receptors revealed with brief pulses of acetylcholine - |
| Author(s) : Graef JD , Fedorov NB , Benson LC , Hyman J , Lippiello PM , Bencherif M |
| Ref : Biochemical Pharmacology , 82 :1025 , 2011 |
| PubMedID: |
| Title : Application of alpha7 nicotinic acetylcholine receptor agonists in inflammatory diseases: an overview - Marrero_2011_Pharm.Res_28_413 |
| Author(s) : Marrero MB , Bencherif M , Lippiello PM , Lucas R |
| Ref : Pharm Res , 28 :413 , 2011 |
| Abstract : |
| PubMedSearch : Marrero_2011_Pharm.Res_28_413 |
| PubMedID: 20859658 |
| Title : Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases - Bencherif_2011_Cell.Mol.Life.Sci_68_931 |
| Author(s) : Bencherif M , Lippiello PM , Lucas R , Marrero MB |
| Ref : Cell Mol Life Sciences , 68 :931 , 2011 |
| Abstract : |
| PubMedSearch : Bencherif_2011_Cell.Mol.Life.Sci_68_931 |
| PubMedID: 20953658 |
| Title : Poster: Tethered pentamersLow sensitivity alpha4\/beta2-nicotinic acetylcholine receptors - |
| Author(s) : Lucero L , Bhakta M , Liu G , Wu J , Hauser TA , Bencherif M , Bermudez I , Whiteaker P , Lukas RJ |
| Ref : Biochemical Pharmacology , 82 :1025 , 2011 |
| PubMedID: |
| Title : Poster: Effects of incorporation of alpha5 subunits into alpha4\/beta2 nicotinic acetylcholine receptors on pharmacological functions of nicotinic ligands - |
| Author(s) : Zhang J , Bencherif M , Hauser T |
| Ref : Biochemical Pharmacology , 82 :1024 , 2011 |
| PubMedID: |
| Title : Alpha7 neuronal nicotinic receptors as targets for novel therapies to treat multiple domains of schizophrenia - Kucinski_2011_Curr.Pharm.Biotechnol_12_437 |
| Author(s) : Kucinski AJ , Stachowiak MK , Wersinger SR , Lippiello PM , Bencherif M |
| Ref : Curr Pharm Biotechnol , 12 :437 , 2011 |
| Abstract : |
| PubMedSearch : Kucinski_2011_Curr.Pharm.Biotechnol_12_437 |
| PubMedID: 21133847 |
| Title : Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor - Lummis_2011_J.Pharmacol.Exp.Ther_339_125 |
| Author(s) : Lummis SC , Thompson AJ , Bencherif M , Lester HA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 339 :125 , 2011 |
| Abstract : |
| PubMedSearch : Lummis_2011_J.Pharmacol.Exp.Ther_339_125 |
| PubMedID: 21775477 |
| Title : Poster: A methodological comparison of human alpha4\/beta2 and alpha3\/beta4 receptor properties using conventional and high-throughput patch-clamp electrophysiology techniques - |
| Author(s) : Benson LC , Sidach SS , Graef JD , Lippiello PM , Bencherif M , Fedorov NB |
| Ref : Biochemical Pharmacology , 82 :1025 , 2011 |
| PubMedID: |
| Title : An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes - Marrero_2010_J.Pharmacol.Exp.Ther_332_173 |
| Author(s) : Marrero MB , Lucas R , Salet C , Hauser TA , Mazurov A , Lippiello PM , Bencherif M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 332 :173 , 2010 |
| Abstract : |
| PubMedSearch : Marrero_2010_J.Pharmacol.Exp.Ther_332_173 |
| PubMedID: 19786623 |
| Title : Alpha7 neuronal nicotinic receptors: the missing link to understanding Alzheimer's etiopathology? - Bencherif_2010_Med.Hypotheses_74_281 |
| Author(s) : Bencherif M , Lippiello PM |
| Ref : Med Hypotheses , 74 :281 , 2010 |
| Abstract : |
| PubMedSearch : Bencherif_2010_Med.Hypotheses_74_281 |
| PubMedID: 19800174 |
| Title : Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors - Grady_2010_Neuropharmacol_58_1054 |
| Author(s) : Grady SR , Drenan RM , Breining SR , Yohannes D , Wageman CR , Fedorov NB , McKinney S , Whiteaker P , Bencherif M , Lester HA , Marks MJ |
| Ref : Neuropharmacology , 58 :1054 , 2010 |
| Abstract : |
| PubMedSearch : Grady_2010_Neuropharmacol_58_1054 |
| PubMedID: 20114055 |
| Title : Poster: Effects of nicotine on real-time dopamine dynamics in rat nucleus accumbens: In vivo voltammetric study - |
| Author(s) : Grinevich VP , O'Connor JA , Bencherif M , Budygin EA |
| Ref : Biochemical Pharmacology , 78 :916 , 2009 |
| PubMedID: |
| Title : TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia - Hauser_2009_Biochem.Pharmacol_78(7)_803 |
| Author(s) : Hauser TA , Kucinski A , Jordan KG , Gatto GJ , Wersinger SR , Hesse RA , Stachowiak EK , Stachowiak MK , Papke RL , Lippiello PM , Bencherif M |
| Ref : Biochemical Pharmacology , 78 :803 , 2009 |
| Abstract : |
| PubMedSearch : Hauser_2009_Biochem.Pharmacol_78(7)_803 |
| PubMedID: 19482012 |
| Title : Poster: Effect of partial nicotinic agonists on real-time dopamine responses in rat nucleus accumbens: In vivo voltammetric study - |
| Author(s) : OConnor JA , Budygin EA , Grinevich VP , Bencherif M |
| Ref : Biochemical Pharmacology , 78 :917 , 2009 |
| PubMedID: |
| Title : Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype - Breining_2009_Bioorg.Med.Chem.Lett_19_4359 |
| Author(s) : Breining SR , Bencherif M , Grady SR , Whiteaker P , Marks MJ , Wageman CR , Lester HA , Yohannes D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4359 , 2009 |
| Abstract : |
| PubMedSearch : Breining_2009_Bioorg.Med.Chem.Lett_19_4359 |
| PubMedID: 19560354 |
| Title : In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors - Drenan_2008_Neuron_60_123 |
| Author(s) : Drenan RM , Grady SR , Whiteaker P , McClure-Begley TD , McKinney S , Miwa JM , Bupp S , Heintz N , McIntosh JM , Bencherif M , Marks MJ , Lester HA |
| Ref : Neuron , 60 :123 , 2008 |
| Abstract : |
| PubMedSearch : Drenan_2008_Neuron_60_123 |
| PubMedID: 18940593 |
| Title : Nicotinic receptors as targets for therapeutic discovery - Lippiello_2007_Expert.Opin.Drug.Discov_2_1185 |
| Author(s) : Lippiello P , Bencherif M , Hauser T , Jordan K , Letchworth S , Mazurov A |
| Ref : Expert Opin Drug Discov , 2 :1185 , 2007 |
| Abstract : |
| PubMedSearch : Lippiello_2007_Expert.Opin.Drug.Discov_2_1185 |
| PubMedID: 23496128 |
| Title : Ispronicline: a novel alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties - Lippiello_2006_J.Mol.Neurosci_30_19 |
| Author(s) : Lippiello P , Letchworth SR , Gatto GJ , Traina VM , Bencherif M |
| Ref : Journal of Molecular Neuroscience , 30 :19 , 2006 |
| Abstract : |
| PubMedSearch : Lippiello_2006_J.Mol.Neurosci_30_19 |
| PubMedID: 17192610 |
| Title : Therapeutic potential of novel selective drugs targeting nicotinic acetylcholine receptors - Bencherif_2006_J.Mol.Neurosci_30_17 |
| Author(s) : Bencherif M , Hauser TA , Jordan KG , Gatto GJ |
| Ref : Journal of Molecular Neuroscience , 30 :17 , 2006 |
| Abstract : |
| PubMedSearch : Bencherif_2006_J.Mol.Neurosci_30_17 |
| PubMedID: 17192609 |
| Title : Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance - Buccafusco_2005_Trends.Pharmacol.Sci_26_352 |
| Author(s) : Buccafusco JJ , Letchworth SR , Bencherif M , Lippiello PM |
| Ref : Trends in Pharmacological Sciences , 26 :352 , 2005 |
| Abstract : |
| PubMedSearch : Buccafusco_2005_Trends.Pharmacol.Sci_26_352 |
| PubMedID: 15946748 |
| Title : Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit - Grinevich_2005_J.Pharmacol.Exp.Ther_312_619 |
| Author(s) : Grinevich VP , Letchworth SR , Lindenberger KA , Menager J , Mary V , Sadieva KA , Buhlman LM , Bohme GA , Pradier L , Benavides J , Lukas RJ , Bencherif M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 312 :619 , 2005 |
| Abstract : |
| PubMedSearch : Grinevich_2005_J.Pharmacol.Exp.Ther_312_619 |
| PubMedID: 15356217 |
| Title : TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant, neuroprotective and long-lasting cognitive effects - Gatto_2004_CNS.Drug.Rev_10_147 |
| Author(s) : Gatto GJ , Bohme GA , Caldwell WS , Letchworth SR , Traina VM , Obinu MC , Laville M , Reibaud M , Pradier L , Dunbar GC , Bencherif M |
| Ref : CNS Drug Rev , 10 :147 , 2004 |
| Abstract : |
| PubMedSearch : Gatto_2004_CNS.Drug.Rev_10_147 |
| PubMedID: 15179444 |
| Title : RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization - Lippiello_1996_J.Pharmacol.Exp.Ther_279_1422 |
| Author(s) : Lippiello PM , Bencherif M , Gray JA , Peters S , Grigoryan G , Hodges H , Collins AC |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 279 :1422 , 1996 |
| Abstract : |
| PubMedSearch : Lippiello_1996_J.Pharmacol.Exp.Ther_279_1422 |
| PubMedID: 8968367 |