| Title : Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors - Carlier_1999_Bioorg.Med.Chem.Lett_9_2335 |
| Author(s) : Carlier PR , Du DM , Han Y , Liu J , Pang YP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 9 :2335 , 1999 |
|
Abstract :
Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials. The optimum hybrid inhibitor (+/-)-9g is 13-fold more potent than (-)-huperzine A, and 25-fold more potent than tacrine. |
| PubMedSearch : Carlier_1999_Bioorg.Med.Chem.Lett_9_2335 |
| PubMedID: 10476864 |
Carlier PR, Du DM, Han Y, Liu J, Pang YP (1999)
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett
9 :2335
Carlier PR, Du DM, Han Y, Liu J, Pang YP (1999)
Bioorganic & Medicinal Chemistry Lett
9 :2335