Carlier PR

General

Full name : Carlier Paul R

First name : Paul

Mail : Department of Chemistry\; Virginia Tech\; Blacksburg\; VA 24061

Zip Code :

City :

Country : USA

Email : pcarlier@vt.edu

Phone : +15402319219

Fax :

Website : \/\/www.carlierlab.com

Directory :

References (48)

Title : Promising tacrine\/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget - Mak_2021_J.Neurochem__
Author(s) : Mak S , Li W , Fu H , Luo J , Cui W , Hu S , Pang Y , Carlier PR , Tsim KWK , Pi R , Han Y
Ref : Journal of Neurochemistry , : , 2021
PubMedID: 33930191

Title : Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease - Xuan_2021_ACS.Chem.Neurosci_12_2462
Author(s) : Xuan Z , Gu X , Yan S , Xie Y , Zhou Y , Zhang H , Jin H , Hu S , Mak MSH , Zhou D , Tsim KWK , Carlier PR , Han Y , Cui W
Ref : ACS Chem Neurosci , 12 :2462 , 2021
PubMedID: 34156230

Title : Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates - Mutunga_2019_Int.J.Environ.Res.Public.Health_16_
Author(s) : Mutunga JM , Ma M , Chen QH , Hartsel JA , Wong DM , Ding S , Totrov M , Carlier PR , Bloomquist JR
Ref : Int J Environ Research Public Health , 16 : , 2019
PubMedID: 31035318

Title : Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance - Cheung_2018_Structure_26_130
Author(s) : Cheung J , Mahmood A , Kalathur R , Liu L , Carlier PR
Ref : Structure , 26 :130 , 2018
PubMedID: 29276037
Gene_locus related to this paper: anoga-ACHE1

Title : Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae - Han_2018_Insect.Sci_25_721
Author(s) : Han Q , Wong DM , Robinson H , Ding H , Lam PC , Totrov MM , Carlier PR , Li J
Ref : Insect Sci , 25 :721 , 2018
PubMedID: 28247978
Gene_locus related to this paper: anoga-ACHE1

Title : Select beta- and gamma-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase - Carlier_2018_Pestic.Biochem.Physiol_151_32
Author(s) : Carlier PR , Chen QH , Verma A , Wong DM , Mutunga JM , Muller J , Islam R , Shimozono AM , Tong F , Li J , Totrov M , Bloomquist JR
Ref : Pestic Biochem Physiol , 151 :32 , 2018
PubMedID: 30524149

Title : Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice - Chen_2018_Front.Cell.Neurosci_12_396
Author(s) : Chen H , Wu X , Gu X , Zhou Y , Ye L , Zhang K , Pan H , Wang J , Wei H , Zhu B , Naman CB , Mak SH , Carlier PR , Cui W , Han YF
Ref : Front Cell Neurosci , 12 :396 , 2018
PubMedID: 30483056

Title : Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito - Carlier_2017_Curr.Med.Chem_24_2946
Author(s) : Carlier PR , Bloomquist JR , Totrov M , Li J
Ref : Curr Med Chem , 24 :2946 , 2017
PubMedID: 28176636

Title : Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase - Camerino_2015_Bioorg.Med.Chem.Lett_25_4405
Author(s) : Camerino E , Wong DM , Tong F , Korber F , Gross AD , Islam R , Viayna E , Mutunga JM , Li J , Totrov MM , Bloomquist JR , Carlier PR
Ref : Bioorganic & Medicinal Chemistry Lett , 25 :4405 , 2015
PubMedID: 26386602

Title : Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management - Swale_2015_Pest.Manag.Sci_71_1158
Author(s) : Swale DR , Carlier PR , Hartsel JA , Ma M , Bloomquist JR
Ref : Pest Manag Sci , 71 :1158 , 2015
PubMedID: 25185896
Gene_locus related to this paper: anoga-ACHE1

Title : Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae - Mutunga_2015_Pestic.Biochem.Physiol_121_116
Author(s) : Mutunga JM , Anderson TD , Craft DT , Gross AD , Swale DR , Tong F , Wong DM , Carlier PR , Bloomquist JR
Ref : Pestic Biochem Physiol , 121 :116 , 2015
PubMedID: 26047119

Title : 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae - Verma_2015_Bioorg.Med.Chem_23_1321
Author(s) : Verma A , Wong DM , Islam R , Tong F , Ghavami M , Mutunga JM , Slebodnick C , Li J , Viayna E , Lam PC , Totrov MM , Bloomquist JR , Carlier PR
Ref : Bioorganic & Medicinal Chemistry , 23 :1321 , 2015
PubMedID: 25684426

Title : Inhibiting beta-Amyloid-Associated Alzheimer's Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue - Hu_2015_J.Mol.Neurosci_55_1014
Author(s) : Hu S , Wang R , Cui W , Zhang Z , Mak SH , Xu D , Choi C , Tsim KWK , Carlier PR , Lee M , Han Y
Ref : Journal of Molecular Neuroscience , 55 :1014 , 2015
PubMedID: 25407821

Title : Structural genomics for drug design against the pathogen Coxiella burnetii - Franklin_2015_Proteins_83_2124
Author(s) : Franklin MC , Cheung J , Rudolph MJ , Burshteyn F , Cassidy M , Gary E , Hillerich B , Yao ZK , Carlier PR , Totrov M , Love JD
Ref : Proteins , 83 :2124 , 2015
PubMedID: 26033498
Gene_locus related to this paper: coxbu-CBU1769

Title : Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant - Temeyer_2014_Parasit.Vectors_7_577
Author(s) : Temeyer KB , Tong F , Totrov MM , Tuckow AP , Chen QH , Carlier PR , Perez de Leon AA , Bloomquist JR
Ref : Parasit Vectors , 7 :577 , 2014
PubMedID: 25491113
Gene_locus related to this paper: phlpp-m1f887

Title : Aryl methylcarbamates: Potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae - Wong_2013_Chem.Biol.Interact_203_314
Author(s) : Wong DM , Li J , Lam PC , Hartsel JA , Mutunga JM , Totrov M , Bloomquist JR , Carlier PR
Ref : Chemico-Biological Interactions , 203 :314 , 2013
PubMedID: 22989775
Gene_locus related to this paper: anoga-ACHE1

Title : Inhibitor profile of (n)-tacrines -methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi - Swale_2013_Pestic.Biochem.Physiol_106_
Author(s) : Swale DR , Tong F , Temeyer KB , Li A , Lam PC , Totrov MM , Carlier PR , Perez de Leon AA , Bloomquist JR
Ref : Pesticide Biochemistry and Physiology , 106 : , 2013
PubMedID: 24187393
Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Neurotoxicology of bis(n)-Tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase - Mutunga_2013_Arch.Insect.Biochem.Physiol_83_180
Author(s) : Mutunga JM , Boina DR , Anderson TD , Bloomquist JR , Carlier PR , Wong DM , Lam PC , Totrov MM
Ref : Archives of Insect Biochemistry & Physiology , 83 :180 , 2013
PubMedID: 23740645

Title : Evaluation of novel carbamate insecticides for neurotoxicity to non-target species - Jiang_2013_Pestic.Biochem.Physiol_106_156
Author(s) : Jiang Y , Swale D , Carlier PR , Hartsel JA , Ma M , Ekstrom F , Bloomquist JR
Ref : Pesticide Biochemistry and Physiology , 106 :156 , 2013
PubMedID:

Title : Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase - Tong_2013_Pestic.Biochem.Physiol_106_79
Author(s) : Tong F , Islam RM , Carlier PR , Ma M , Ekstrom F , Bloomquist JR
Ref : Pesticide Biochemistry and Physiology , 106 :79 , 2013
PubMedID: 24003261

Title : Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase - Hartsel_2012_Bioorg.Med.Chem.Lett_22_4593
Author(s) : Hartsel JA , Wong DM , Mutunga JM , Ma M , Anderson TD , Wysinski A , Islam R , Wong EA , Paulson SL , Li J , Lam PC , Totrov MM , Bloomquist JR , Carlier PR
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :4593 , 2012
PubMedID: 22738634
Gene_locus related to this paper: anoga-ACHE1

Title : Select small core structure carbamates exhibit high contact toxicity to carbamate-resistant strain malaria mosquitoes, Anopheles gambiae (Akron) - Wong_2012_PLoS.One_7_e46712
Author(s) : Wong DM , Li J , Chen QH , Han Q , Mutunga JM , Wysinski A , Anderson TD , Ding H , Carpenetti TL , Verma A , Islam R , Paulson SL , Lam PC , Totrov M , Bloomquist JR , Carlier PR
Ref : PLoS ONE , 7 :e46712 , 2012
PubMedID: 23049714
Gene_locus related to this paper: anoga-ACHE1

Title : Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR - Cui_2011_Brain.Res_1401_10
Author(s) : Cui W , Cui GZ , Li W , Zhang Z , Hu S , Mak SH , Zhang H , Carlier PR , Choi CL , Wong YT , Lee SM , Han YF
Ref : Brain Research , 1401 :10 , 2011
PubMedID: 21665194

Title : Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2\/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone - Cui_2011_Brain.Res_1394_14
Author(s) : Cui W , Li W , Zhao Y , Mak SH , Gao Y , Luo J , Zhang H , Liu Y , Carlier PR , Rong J , Han YF
Ref : Brain Research , 1394 :14 , 2011
PubMedID: 21315693

Title : Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets - Zhao_2011_Brain.Res_1421_100
Author(s) : Zhao Y , Dou J , Luo J , Li W , Chan HH , Cui W , Zhang H , Han R , Carlier PR , Zhang X , Han Y
Ref : Brain Research , 1421 :100 , 2011
PubMedID: 21978549

Title : Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae - Carlier_2008_Chem.Biol.Interact_175_368
Author(s) : Carlier PR , Anderson TD , Wong DM , Hsu DC , Hartsel J , Ma M , Wong EA , Choudhury R , Lam PC , Totrov MM , Bloomquist JR
Ref : Chemico-Biological Interactions , 175 :368 , 2008
PubMedID: 18554580
Gene_locus related to this paper: anoga-ACHE1

Title : The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine - Yu_2008_J.Pharm.Biomed.Anal_46_75
Author(s) : Yu H , Li WM , Kan KK , Ho JM , Carlier PR , Pang YP , Gu ZM , Zhong Z , Chan K , Wang YT , Han YF
Ref : J Pharm Biomed Anal , 46 :75 , 2008
PubMedID: 17931815

Title : East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A - Li_2007_Curr.Alzheimer.Res_4_386
Author(s) : Li WM , Kan KK , Carlier PR , Pang YP , Han YF
Ref : Curr Alzheimer Res , 4 :386 , 2007
PubMedID: 17908041

Title : Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge - Rydberg_2006_J.Med.Chem_49_5491
Author(s) : Rydberg EH , Brumshtein B , Greenblatt HM , Wong DM , Shaya D , Williams LD , Carlier PR , Pang YP , Silman I , Sussman JL
Ref : Journal of Medicinal Chemistry , 49 :5491 , 2006
PubMedID: 16942022
Gene_locus related to this paper: torca-ACHE

Title : Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase - Haviv_2005_J.Am.Chem.Soc_127_11029
Author(s) : Haviv H , Wong DM , Greenblatt HM , Carlier PR , Pang YP , Silman I , Sussman JL
Ref : Journal of the American Chemical Society , 127 :11029 , 2005
PubMedID: 16076210
Gene_locus related to this paper: torca-ACHE

Title : Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors - Li_2005_J.Biol.Chem_280_18179
Author(s) : Li W , Pi R , Chan HH , Fu H , Lee NT , Tsang HW , Pu Y , Chang DC , Li C , Luo J , Xiong K , Li Z , Xue H , Carlier PR , Pang Y , Tsim KWK , Li M , Han Y
Ref : Journal of Biological Chemistry , 280 :18179 , 2005
PubMedID: 15710623

Title : Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease - Du_2004_Curr.Pharm.Des_10_3141
Author(s) : Du DM , Carlier PR
Ref : Curr Pharm Des , 10 :3141 , 2004
PubMedID: 15544504

Title : Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity - Wong_2003_J.Am.Chem.Soc_125_363
Author(s) : Wong DM , Greenblatt HM , Dvir H , Carlier PR , Han YF , Pang YP , Silman I , Sussman JL
Ref : J Am Chem Soc , 125 :363 , 2003
PubMedID: 12517147
Gene_locus related to this paper: torca-ACHE

Title : Cover picture: angew. Chem. Int. Ed. 6\/2002 - Lewis_2002_Angew.Chem.Int.Ed.Engl_41_875
Author(s) : Lewis WG , Green LG , Grynszpan F , Radic Z , Carlier PR , Taylor P , Finn MG , Sharpless KB
Ref : Angew Chem Int Ed Engl , 41 :875 , 2002
PubMedID:

Title : Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks -
Author(s) : Lewis WG , Green LG , Grynszpan F , Radic Z , Carlier PR , Taylor P , Finn MG , Sharpless KB
Ref : Angew Chem Int Ed Engl , 41 :1053 , 2002
PubMedID: 12491310

Title : Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product -
Author(s) : Carlier PR , Du DM , Han YF , Liu J , Perola E , Williams ID , Pang YP
Ref : Angew Chem Int Ed Engl , 39 :1775 , 2000
PubMedID: 10934357

Title : Enzyme biosensor for studying therapeutics of Alzheimer's disease - Lenigk_2000_Biosens.Bioelectron_15_541
Author(s) : Lenigk R , Lam E , Lai A , Wang H , Han Y , Carlier PR , Renneberg R
Ref : Biosensors & Bioelectronics , 15 :541 , 2000
PubMedID: 11419651

Title : Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats - Liu_2000_Neurosci.Lett_282_165
Author(s) : Liu J , Ho W , Lee NT , Carlier PR , Pang Y , Han Y
Ref : Neuroscience Letters , 282 :165 , 2000
PubMedID: 10717417

Title : Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected] - Wu_2000_Neurosci.Lett_288_95
Author(s) : Wu DC , Xiao XQ , Ng AK , Chen PM , Chung W , Lee NT , Carlier PR , Pang YP , Yu AC , Han YF
Ref : Neuroscience Letters , 288 :95 , 2000
PubMedID: 10876069

Title : Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor' -
Author(s) : Wu D , Xiao X , Ng AK , Chen PM , Chung W , Lee NT , Carlier PR , Pang Y , Yu AC , Han Y
Ref : Neuroscience Letters , 290 :84 , 2000
PubMedID: 10925180

Title : Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine - Xiao_2000_Neurosci.Lett_290_197
Author(s) : Xiao XQ , Lee NT , Carlier PR , Pang Y , Han YF
Ref : Neuroscience Letters , 290 :197 , 2000
PubMedID: 10963897

Title : Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors - Carlier_1999_Bioorg.Med.Chem.Lett_9_2335
Author(s) : Carlier PR , Du DM , Han Y , Liu J , Pang YP
Ref : Bioorganic & Medicinal Chemistry Lett , 9 :2335 , 1999
PubMedID: 10476864

Title : Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist - Li_1999_Neuroreport_10_795
Author(s) : Li CY , Wang H , Xue H , Carlier PR , Hui KM , Pang YP , Li ZW , Han YF
Ref : Neuroreport , 10 :795 , 1999
PubMedID: 10208550

Title : Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE - Wang_1999_Neuroreport_10_789
Author(s) : Wang H , Carlier PR , Ho WL , Wu DC , Lee NT , Li CP , Pang YP , Han YF
Ref : Neuroreport , 10 :789 , 1999
PubMedID: 10208549

Title : Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor - Wang_1999_Zhongguo.Yao.Li.Xue.Bao_20_211
Author(s) : Wang H , Carlier PR , Ho WL , Lee NT , Pang YP , Han YF
Ref : Zhongguo Yao Li Xue Bao , 20 :211 , 1999
PubMedID: 10452094

Title : Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions - Carlier_1999_J.Med.Chem_42_4225
Author(s) : Carlier PR , Chow ES , Han Y , Liu J , El Yazal J , Pang YP
Ref : Journal of Medicinal Chemistry , 42 :4225 , 1999
PubMedID: 10514292

Title : Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis - Carlier_1999_Bioorg.Med.Chem_7_351
Author(s) : Carlier PR , Han YF , Chow ES , Li CP , Wang H , Lieu TX , Wong HS , Pang YP
Ref : Bioorganic & Medicinal Chemistry , 7 :351 , 1999
PubMedID: 10218828

Title : Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities - Han_1999_Bioorg.Med.Chem_7_2569
Author(s) : Han YF , Li CP , Chow E , Wang H , Pang YP , Carlier PR
Ref : Bioorganic & Medicinal Chemistry , 7 :2569 , 1999
PubMedID: 10632067