| Title : Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity - Chellappan_2006_J.Med.Chem_49_2673 |
| Author(s) : Chellappan SK , Xiao Y , Tueckmantel W , Kellar KJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 49 :2673 , 2006 |
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Abstract :
We report the synthesis and pharmacological properties of several cytisine derivatives. Among them, two 10-substituted derivatives showed much higher selectivities for the alpha4beta2 nAChR subtype in binding assays than cytisine. The 9-vinyl derivative was found to have a very similar agonist activity profile to that of cytisine. |
| PubMedSearch : Chellappan_2006_J.Med.Chem_49_2673 |
| PubMedID: 16640326 |
Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP (2006)
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity
Journal of Medicinal Chemistry
49 :2673
Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP (2006)
Journal of Medicinal Chemistry
49 :2673