| Title : The genomic sequence of the accidental pathogen Legionella pneumophila - Chien_2004_Science_305_1966 |
| Author(s) : Chien M , Morozova I , Shi S , Sheng H , Chen J , Gomez SM , Asamani G , Hill K , Nuara J , Feder M , Rineer J , Greenberg JJ , Steshenko V , Park SH , Zhao B , Teplitskaya E , Edwards JR , Pampou S , Georghiou A , Chou IC , Iannuccilli W , Ulz ME , Kim DH , Geringer-Sameth A , Goldsberry C , Morozov P , Fischer SG , Segal G , Qu X , Rzhetsky A , Zhang P , Cayanis E , de Jong PJ , Ju J , Kalachikov S , Shuman HA , Russo JJ |
| Ref : Science , 305 :1966 , 2004 |
|
Abstract :
We present the genomic sequence of Legionella pneumophila, the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets. |
| PubMedSearch : Chien_2004_Science_305_1966 |
| PubMedID: 15448271 |
| Gene_locus related to this paper: legph-q5zsu4 , legpa-q5x2r4 , legpa-q5x3a5 , legpa-q5x3d6 , legpa-q5x4r4 , legpa-q5x4t1 , legpa-q5x5b2 , legpa-q5x5z2 , legpa-q5x7f5 , legpa-q5x8e6 , legpa-q5x8m4 , legpa-q5x322 , legpa-q5x405 , legpa-q5x424 , legpa-q5x473 , legpa-q5x590 , legpa-q5x611 , legpa-q5x819 , legpc-a5iar0 , legph-q5zrh1 , legph-q5zsb5 , legph-q5zv00 , legph-q5zwi8 , legph-q5zze3 , legpl-q5wtd3 , legpl-q5wua5 , legpl-q5wvw9 , legpn-Q8KU34 , legpn-Q8RNQ1 , legpn-SBPA , legpn-i7i328 , legpl-q5wsw9 |
Chien M, Morozova I, Shi S, Sheng H, Chen J, Gomez SM, Asamani G, Hill K, Nuara J, Feder M, Rineer J, Greenberg JJ, Steshenko V, Park SH, Zhao B, Teplitskaya E, Edwards JR, Pampou S, Georghiou A, Chou IC, Iannuccilli W, Ulz ME, Kim DH, Geringer-Sameth A, Goldsberry C, Morozov P, Fischer SG, Segal G, Qu X, Rzhetsky A, Zhang P, Cayanis E, de Jong PJ, Ju J, Kalachikov S, Shuman HA, Russo JJ (2004)
The genomic sequence of the accidental pathogen Legionella pneumophila
Science
305 :1966
Chien M, Morozova I, Shi S, Sheng H, Chen J, Gomez SM, Asamani G, Hill K, Nuara J, Feder M, Rineer J, Greenberg JJ, Steshenko V, Park SH, Zhao B, Teplitskaya E, Edwards JR, Pampou S, Georghiou A, Chou IC, Iannuccilli W, Ulz ME, Kim DH, Geringer-Sameth A, Goldsberry C, Morozov P, Fischer SG, Segal G, Qu X, Rzhetsky A, Zhang P, Cayanis E, de Jong PJ, Ju J, Kalachikov S, Shuman HA, Russo JJ (2004)
Science
305 :1966