| Title : PNPLA-mediated lipid hydrolysis and transacylation - At the intersection of catabolism and anabolism - Colaco-Gaspar_2023_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__159410 |
| Author(s) : Colaco-Gaspar M , Hofer P , Oberer M , Zechner R |
| Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , :159410 , 2023 |
|
Abstract :
Patatin-like phospholipase domain containing proteins (PNPLAs) play diverse roles in lipid metabolism. In this review, we focus on the enzymatic properties and predicted 3D structures of PNPLA1-5, PNPLA2-4 exert both catabolic and anabolic functions. Whereas PNPLA1 is predominantly expressed in the epidermis and involved in sphingolipid biosynthesis, PNPLA2 and 4 are ubiquitously expressed and exhibit several enzymatic activities, including hydrolysis and transacylation of various (glycero-)lipid species. This review summarizes known biological roles for PNPLA-mediated hydrolysis and transacylation reactions and highlights open questions concerning their physiological function. |
| PubMedSearch : Colaco-Gaspar_2023_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__159410 |
| PubMedID: 37951382 |
Colaco-Gaspar M, Hofer P, Oberer M, Zechner R (2023)
PNPLA-mediated lipid hydrolysis and transacylation - At the intersection of catabolism and anabolism
Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids
:159410
Colaco-Gaspar M, Hofer P, Oberer M, Zechner R (2023)
Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids
:159410