Cui_2022_Front.Pharmacol_13_1002871

Reference

Title : New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors - Cui_2022_Front.Pharmacol_13_1002871
Author(s) : Cui C , Tian X , Wei L , Wang Y , Wang K , Fu R
Ref : Front Pharmacol , 13 :1002871 , 2022
Abstract :

Dipeptidyl peptidase 8 (DPP8) and 9 (DPP9) are widely expressed in mammals including humans, mainly locate in the cytoplasm. The DPP8 and DPP9 (DPP8/9) belong to serine proteolytic enzymes, they can recognize and cleave N-terminal dipeptides of specific substrates if proline is at the penultimate position. Because the localization of DPP8/9 is different from that of DPP4 and the substrates for DPP8/9 are not yet completely clear, their physiological and pathological roles are still being further explored. In this article, we will review the recent research advances focusing on the expression, regulation, and functions of DPP8/9 in physiology and pathology status. Emerging research results have shown that DPP8/9 is involved in various biological processes such as cell behavior, energy metabolism, and immune regulation, which plays an essential role in maintaining normal development and physiological functions of the body. DPP8/9 is also involved in pathological processes such as tumorigenesis, inflammation, and organ fibrosis. In recent years, related research on immune cell pyroptosis has made DPP8/9 a new potential target for the treatment of hematological diseases. In addition, DPP8/9 inhibitors also have great potential in the treatment of tumors and chronic kidney disease.

PubMedSearch : Cui_2022_Front.Pharmacol_13_1002871
PubMedID: 36172198
Gene_locus related to this paper: human-DPP8 , human-DPP9

Related information

Gene_locus human-DPP8    human-DPP9
Family human-DPP8    human-DPP9    DPP4N_Peptidase_S9

Citations formats

Cui C, Tian X, Wei L, Wang Y, Wang K, Fu R (2022)
New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors
Front Pharmacol 13 :1002871

Cui C, Tian X, Wei L, Wang Y, Wang K, Fu R (2022)
Front Pharmacol 13 :1002871