| Title : NF279: a novel potent and selective antagonist of P2X receptor-mediated responses - Damer_1998_Eur.J.Pharmacol_350_R5 |
| Author(s) : Damer S , Niebel B , Czeche S , Nickel P , Ardanuy U , Schmalzing G , Rettinger J , Mutschler E , Lambrecht G |
| Ref : European Journal of Pharmacology , 350 :R5 , 1998 |
|
Abstract :
8,8'-(Carbonylbis(imino-4, 1 -phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis(1,3, 5-naphthalenetrisulfonic acid) (NF279) antagonized P2X receptor-mediated contractions in rat vas deferens, evoked by alpha,beta-methylene ATP (10 microM; pIC50=5.71) without affecting responses mediated via alpha1A-adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and nicotinic receptors. The low inhibitory potency of NF279 on P2Y receptors in guinea-pig taenia coli (pA2=4.10) and at ecto-nucleotidases in folliculated Xenopus laevis oocytes (IC50 > 100 microM) indicates that NF279 is a novel specific and selective P2X receptor antagonist. |
| PubMedSearch : Damer_1998_Eur.J.Pharmacol_350_R5 |
| PubMedID: 9683026 |
Damer S, Niebel B, Czeche S, Nickel P, Ardanuy U, Schmalzing G, Rettinger J, Mutschler E, Lambrecht G (1998)
NF279: a novel potent and selective antagonist of P2X receptor-mediated responses
European Journal of Pharmacology
350 :R5
Damer S, Niebel B, Czeche S, Nickel P, Ardanuy U, Schmalzing G, Rettinger J, Mutschler E, Lambrecht G (1998)
European Journal of Pharmacology
350 :R5