Title : Dehydroepiandrosterone (DHEA) increases production and release of Alzheimer's amyloid precursor protein - Danenberg_1996_Life.Sci_59_1651 |
Author(s) : Danenberg HD , Haring R , Fisher A , Pittel Z , Gurwitz D , Heldman E |
Ref : Life Sciences , 59 :1651 , 1996 |
Abstract :
Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal cortex, significantly declines with advanced age. We have previously demonstrated that DHEA prevents the reduction in non-amyloidogenic APP processing, following prolonged stimulation of the muscarinic receptor, in PC12 cells that express the ml acetylcholine-receptor. The present study examined whether this effect may be mediated via modulation of APP metabolism. It was found that DHEA treatment increases the content of membrane-associated APP holoprotein by 24%, and the accumulation of secreted APP in the medium by 63%. No increase in viable cell number nor in nonspecific protein production was observed in DHEA-treated cells. Thus, DHEA seems to increase specifically both APP synthesis and secretion. We propose that the age-associated decline in DHEA levels may be related to the pathological APP metabolism observed in Alzheimer's disease. |
PubMedSearch : Danenberg_1996_Life.Sci_59_1651 |
PubMedID: 8913330 |
Danenberg HD, Haring R, Fisher A, Pittel Z, Gurwitz D, Heldman E (1996)
Dehydroepiandrosterone (DHEA) increases production and release of Alzheimer's amyloid precursor protein
Life Sciences
59 :1651
Danenberg HD, Haring R, Fisher A, Pittel Z, Gurwitz D, Heldman E (1996)
Life Sciences
59 :1651