Davda_2014_Medchemcomm_5_268

Reference

Title : Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation - Davda_2014_Medchemcomm_5_268
Author(s) : Davda D , Martin BR
Ref : Medchemcomm , 5 :268 , 2014
Abstract : Protein palmitoylation describes the hydrophobic post-translational modification of cysteine residues in certain proteins, and is required for the spatial organization and composition of cellular membrane environments. Certain palmitoylated proteins are processed by acyl protein thioesterase (APT) enzymes, which catalyze thioester hydrolysis of palmitoylated cysteine residues. Inhibiting APT enzymes disrupts Ras trafficking and attenuates oncogenic growth signaling, highlighting these enzymes as potential therapeutic targets. As members of the serine hydrolase enzyme family, APT enzymes can be assayed by fluorophosphonate activity-based protein profiling (ABPP) methods, allowing rapid profiling of inhibitor selectivity and potency. In this review, we discuss recent progress in the development of potent and selective inhibitors to APT enzymes, including both competitive and non-competitive chemotypes. These examples highlight how ABPP methods integrate with medicinal chemistry for the discovery and optimization of inhibitors in complex proteomes.
ESTHER : Davda_2014_Medchemcomm_5_268
PubMedSearch : Davda_2014_Medchemcomm_5_268
PubMedID: 25558349

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Citations formats

Davda D, Martin BR (2014)
Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation
Medchemcomm 5 :268

Davda D, Martin BR (2014)
Medchemcomm 5 :268