LYsophospholipase_carboxylesterase

Relationship

Family: LYsophospholipase_carboxylesterase

Block: X

Parent Family: No family

Comment

PLP_Cesterase. Abhydrolase_2; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, but different of the family Monoglyceridelipase_lysophospholipase which is part of PF00561 AlphaBeta hydrolase. For bacterial enzymes, this family correspond to family VI of the classification of Arpigny and Jaeger (1999) The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. Another closely related family of hydrolases: the ABHD17-depalmitoylase family contributes to the depalmitoylation of Ras-family GTPases and synaptic proteins. Burger et al. show that Acyl-protein thioesterase structures present a long tunnel for accommodation of long-chain fatty acids and release the product by use of a flexible loop tunnel lid. Homologous deacetylases use a hydrophobic residue to fix the lid and another residue to close the tunnel entrance. This causes loop rigidity changing the catalytic preference to deacetylation. SOBER1 is a protein deacetylase and not an acylprotein thioesterase. Family TE21 in ThYme database

Database

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (27)

Genes Proteins in LYsophospholipase_carboxylesterase family (350)

Fragments of genes in LYsophospholipase_carboxylesterase family (14)

Structures in LYsophospholipase_carboxylesterase family (27)

Substrates in LYsophospholipase_carboxylesterase family (22)

Inhibitors in LYsophospholipase_carboxylesterase family (24)

References (17)

Title : Thioesterase enzyme families: Functions, structures, and mechanisms - Caswell_2021_Protein.Sci__
Author(s) : Caswell BT , de Carvalho CC , Nguyen H , Roy M , Nguyen T , Cantu DC
Ref : Protein Science , : , 2021
PubMedID: 34921469

Title : Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling - Wepy_2019_J.Lipid.Res_60_360
Author(s) : Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ
Ref : J Lipid Res , 60 :360 , 2019
PubMedID: 30482805
Gene_locus related to this paper: human-LYPLA2

Title : Protein depalmitoylases - Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83
Author(s) : Won SJ , Cheung See Kit M , Martin BR
Ref : Crit Rev Biochem Mol Biol , 53 :83 , 2018
PubMedID: 29239216

Title : A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors - Burger_2017_Nat.Commun_8_2201
Author(s) : Burger M , Willige BC , Chory J
Ref : Nat Commun , 8 :2201 , 2017
PubMedID: 29259199
Gene_locus related to this paper: maize-b6t1C9 , arath-SOBR1 , arath-SOBRL , arath-AT5G20060

Title : Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2) - Won_2016_ACS.Chem.Biol_11_3374
Author(s) : Won SJ , Davda D , Labby KJ , Hwang SY , Pricer R , Majmudar JD , Armacost KA , Rodriguez LA , Rodriguez CL , Chong FS , Torossian KA , Palakurthi J , Hur ES , Meagher JL , Brooks CL, 3rd , Stuckey JA , Martin BR
Ref : ACS Chemical Biology , 11 :3374 , 2016
PubMedID: 27748579
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2

Title : Large-scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis - Filippova_2013_J.Biol.Chem_288_10522
Author(s) : Filippova EV , Weston LA , Kuhn ML , Geissler B , Gehring AM , Armoush N , Adkins CT , Minasov G , Dubrovska I , Shuvalova L , Winsor JR , Lavis LD , Satchell KJ , Becker DP , Anderson WF , Johnson RJ
Ref : Journal of Biological Chemistry , 288 :10522 , 2013
PubMedID: 23430251
Gene_locus related to this paper: fratt-q5ni32

Title : Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution - Ma_2013_Appl.Microbiol.Biotechnol_97_4897
Author(s) : Ma J , Wu L , Guo F , Gu J , Tang X , Jiang L , Liu J , Zhou J , Yu H
Ref : Applied Microbiology & Biotechnology , 97 :4897 , 2013
PubMedID: 22987200
Gene_locus related to this paper: rhos4-q3j2v1

Title : Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases - Burger_2012_J.Lipid.Res_53_43
Author(s) : Burger M , Zimmermann TJ , Kondoh Y , Stege P , Watanabe N , Osada H , Waldmann H , Vetter IR
Ref : J Lipid Res , 53 :43 , 2012
PubMedID: 22052940
Gene_locus related to this paper: human-LYPLAL1

Title : ThYme: a database for thioester-active enzymes - Cantu_2011_Nucleic.Acids.Res_39_D342
Author(s) : Cantu DC , Chen Y , Lemons ML , Reilly PJ
Ref : Nucleic Acids Research , 39 :D342 , 2011
PubMedID: 21045059

Title : Regulation and structure of YahD, a copper-inducible alpha\/beta serine hydrolase of Lactococcus lactis IL1403 - Martinez_2011_FEMS.Microbiol.Lett_314_57
Author(s) : Martinez J , Mancini S , Tauberger E , Weise C , Saenger W , Solioz M
Ref : FEMS Microbiology Letters , 314 :57 , 2011
PubMedID: 21059179
Gene_locus related to this paper: lacla-YAHD

Title : Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study - Pesaresi_2010_Biochimie_92_1787
Author(s) : Pesaresi A , Lamba D
Ref : Biochimie , 92 :1787 , 2010
PubMedID: 20850500
Gene_locus related to this paper: pseae-PA3859

Title : Thioesterases: a new perspective based on their primary and tertiary structures. - Cantu_2010_Protein.Sci_19_1281
Author(s) : Cantu DC , Chen Y , Reilly PJ
Ref : Protein Science , 19 :1281 , 2010
PubMedID: 20506386

Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390
Author(s) : Jaeger KE , Eggert T
Ref : Curr Opin Biotechnol , 13 :390 , 2002
PubMedID: 12323363

Title : Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A - Devedjiev_2000_Structure_8_1137
Author(s) : Devedjiev Y , Dauter Z , Kuznetsov SR , Jones TL , Derewenda ZS
Ref : Structure , 8 :1137 , 2000
PubMedID: 11080636
Gene_locus related to this paper: human-LYPLA1

Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177
Author(s) : Arpigny JL , Jaeger KE
Ref : Biochemical Journal , 343 :177 , 1999
PubMedID: 10493927

Title : cDNA cloning and expression of a novel family of enzymes with calcium-independent phospholipase A2 and lysophospholipase activities - Portilla_1998_J.Am.Soc.Nephrol_9_1178
Author(s) : Portilla D , Crew MD , Grant D , Serrero G , Bates LM , Dai G , Sasner M , Cheng J , Buonanno A
Ref : J Am Soc Nephrol , 9 :1178 , 1998
PubMedID: 9644627
Gene_locus related to this paper: rabit-lypla1 , rabit-O77820 , ratno-lypla1a

Title : Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha\/beta hydrolase with broad substrate specificity - Kim_1997_Structure_5_1571
Author(s) : Kim KK , Song HK , Shin DH , Hwang KY , Choe S , Yoo OJ , Suh SW
Ref : Structure , 5 :1571 , 1997
PubMedID: 9438866
Gene_locus related to this paper: psefl-cxest