human-LYPLA1

Homo sapiens (Human) lysophospholipase I (LYPLA1) APT1, acyl-protein thioesterase 1 S-depalmitoylase

Comment

Previously characterized as lysophospholipase I, but has several hudred-fold higher activity as a protein thioesterase. Acyl protein thioesterase apt1, which catalyzes depalmitoylation of Galpha proteins and Ras. S-depalmitoylase found both in cytoplasm and mitochondria || . A shorter form exists as a splice variant AF077199 nuc 4679011 pep 4679012 || . Q9UQF9 probable isoform of same gene

Relationship

Family : LYsophospholipase_carboxylesterase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Sequence

Peptide

MCGNNMSTPL PAIVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIRSSHIK YICPHAPVRP VTLNMNVAMP SWFDIIGLSP DSQEDESGIK QAAENIKALI DQEVKNGIPS NRIILGGFSQ GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFPQGPIGGA NRDISILQCH GDCDPLVPLM FGSLTVEKLK TLVNPANVTF KTYEGMMHSS CQQEMMDVKQ FIDKLLPPID

References (11)

Title : A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability - Harris_2024_Proteins__
Author(s) : Harris WT, 3rd , Altieri I , Gieck I , Johnson RJ
Ref : Proteins , : , 2024
PubMedID: 38179877
Gene_locus related to this paper: human-LYPLA1

Title : Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains - Abrami_2021_Nat.Chem.Biol_17_438
Author(s) : Abrami L , Audagnotto M , Ho S , Marcaida MJ , Mesquita FS , Anwar MU , Sandoz PA , Fonti G , Pojer F , Dal Peraro M , van der Goot FG
Ref : Nat Chemical Biology , 17 :438 , 2021
PubMedID: 33707782
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2

Title : Inhibition of cell proliferation and migration in nonsmall cell lung cancer cells through the suppression of LYPLA1 - Mohammed_2019_Oncol.Rep_41_973
Author(s) : Mohammed A , Zhang C , Zhang S , Shen Q , Li J , Tang Z , Liu H
Ref : Oncol Rep , 41 :973 , 2019
PubMedID: 30431103
Gene_locus related to this paper: human-LYPLA1

Title : Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes - Kathayat_2018_Nat.Commun_9_334
Author(s) : Kathayat RS , Cao Y , Elvira PD , Sandoz PA , Zaballa ME , Springer MZ , Drake LE , Macleod KF , van der Goot FG , Dickinson BC
Ref : Nat Commun , 9 :334 , 2018
PubMedID: 29362370
Gene_locus related to this paper: human-LYPLA1

Title : Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M - Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838
Author(s) : Rusch M , Zimmermann TJ , Burger M , Dekker FJ , Gormer K , Triola G , Brockmeyer A , Janning P , Bottcher T , Sieber SA , Vetter IR , Hedberg C , Waldmann H
Ref : Angew Chem Int Ed Engl , 50 :9838 , 2011
PubMedID: 21905186
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2

Title : Small-molecule inhibition of APT1 affects Ras localization and signaling - Dekker_2010_Nat.Chem.Biol_6_449
Author(s) : Dekker FJ , Rocks O , Vartak N , Menninger S , Hedberg C , Balamurugan R , Wetzel S , Renner S , Gerauer M , Scholermann B , Rusch M , Kramer JW , Rauh D , Coates GW , Brunsveld L , Bastiaens PI , Waldmann H
Ref : Nat Chemical Biology , 6 :449 , 2010
PubMedID: 20418879
Gene_locus related to this paper: human-LYPLA1

Title : Protein acyl thioesterases (Review) - Zeidman_2009_Mol.Membr.Biol_26_32
Author(s) : Zeidman R , Jackson CS , Magee AI
Ref : Mol Membr Biol , 26 :32 , 2009
PubMedID: 19115143
Gene_locus related to this paper: human-LYPLA1 , human-PPT1

Title : Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A - Devedjiev_2000_Structure_8_1137
Author(s) : Devedjiev Y , Dauter Z , Kuznetsov SR , Jones TL , Derewenda ZS
Ref : Structure , 8 :1137 , 2000
PubMedID: 11080636
Gene_locus related to this paper: human-LYPLA1

Title : Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem\/progenitor cells - Zhang_2000_Genome.Res_10_1546
Author(s) : Zhang QH , Ye M , Wu XY , Ren SX , Zhao M , Zhao CJ , Fu G , Shen Y , Fan HY , Lu G , Zhong M , Xu XR , Han ZG , Zhang JW , Tao J , Huang QH , Zhou J , Hu GX , Gu J , Chen SJ , Chen Z
Ref : Genome Res , 10 :1546 , 2000
PubMedID: 11042152
Gene_locus related to this paper: human-LYPLA1

Title : A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization - Wang_1999_Biochim.Biophys.Acta_1437_157
Author(s) : Wang A , Yang HC , Friedman P , Johnson CA , Dennis EA
Ref : Biochimica & Biophysica Acta , 1437 :157 , 1999
PubMedID: 10064899
Gene_locus related to this paper: human-LYPLA1

Title : A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS) - Duncan_1998_J.Biol.Chem_273_15830
Author(s) : Duncan JA , Gilman AG
Ref : Journal of Biological Chemistry , 273 :15830 , 1998
PubMedID: 9624183
Gene_locus related to this paper: human-LYPLA1 , ratno-lypla1a