| Title : The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594 - Decker_1998_J.Physiol.Paris_92_221 |
| Author(s) : Decker MW , Curzon P , Holladay MW , Nikkel AL , Bitner RS , Bannon AW , Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Williams M , Arneric SP |
| Ref : Journal de Physiologie (Paris) , 92 :221 , 1998 |
|
Abstract :
ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594. |
| PubMedSearch : Decker_1998_J.Physiol.Paris_92_221 |
| PubMedID: 9789812 |
Decker MW, Curzon P, Holladay MW, Nikkel AL, Bitner RS, Bannon AW, Donnelly-Roberts D, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Williams M, Arneric SP (1998)
The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594
Journal de Physiologie (Paris)
92 :221
Decker MW, Curzon P, Holladay MW, Nikkel AL, Bitner RS, Bannon AW, Donnelly-Roberts D, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Williams M, Arneric SP (1998)
Journal de Physiologie (Paris)
92 :221