Arneric SP

General

Full name : Arneric Stephen P

First name : Stephen P

Mail : Neuromed Pharmaceuticals, Vancouver, BC

Zip Code :

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Country : Canada

Email : sarneric@neuromed.com

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References (35)

Title : Neuronal nicotinic receptors: a perspective on two decades of drug discovery research - Arneric_2007_Biochem.Pharmacol_74(8)_1092
Author(s) : Arneric SP , Holladay M , Williams M
Ref : Biochemical Pharmacology , 74 :1092 , 2007
Abstract :
PubMedSearch : Arneric_2007_Biochem.Pharmacol_74(8)_1092
PubMedID: 17662959

Title : Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship - Wishka_2006_J.Med.Chem_49_4425
Author(s) : Wishka DG , Walker DP , Yates KM , Reitz SC , Jia S , Myers JK , Olson KL , Jacobsen EJ , Wolfe ML , Groppi VE , Hanchar AJ , Thornburgh BA , Cortes-Burgos LA , Wong EH , Staton BA , Raub TJ , Higdon NR , Wall TM , Hurst RS , Walters RR , Hoffmann WE , Hajos M , Franklin S , Carey G , Gold LH , Cook KK , Sands SB , Zhao SX , Soglia JR , Kalgutkar AS , Arneric SP , Rogers BN
Ref : Journal of Medicinal Chemistry , 49 :4425 , 2006
Abstract :
PubMedSearch : Wishka_2006_J.Med.Chem_49_4425
PubMedID: 16821801

Title : A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization - Hurst_2005_J.Neurosci_25_4396
Author(s) : Hurst RS , Hajos M , Raggenbass M , Wall TM , Higdon NR , Lawson JA , Rutherford-Root KL , Berkenpas MB , Hoffmann WE , Piotrowski DW , Groppi VE , Allaman G , Ogier R , Bertrand S , Bertrand D , Arneric SP
Ref : Journal of Neuroscience , 25 :4396 , 2005
Abstract :
PubMedSearch : Hurst_2005_J.Neurosci_25_4396
PubMedID: 15858066

Title : Agonists and Antagonists of Nicotinic Acetylcholine Receptors -
Author(s) : Arneric SP , Holladay MW
Ref : Handbook of Experimental Pharmacology , 144 :419 , 2000
PubMedID:

Title : Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant - Briggs_1999_Eur.J.Pharmacol_366_301
Author(s) : Briggs CA , McKenna DG , Monteggia LM , Touma E , Roch JM , Arneric SP , Gopalakrishnan M , Sullivan JP
Ref : European Journal of Pharmacology , 366 :301 , 1999
Abstract :
PubMedSearch : Briggs_1999_Eur.J.Pharmacol_366_301
PubMedID: 10082212

Title : Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice - Holladay_1998_Bioorg.Med.Chem.Lett_8_2797
Author(s) : Holladay MW , Bai H , Li Y , Lin NH , Daanen JF , Ryther KB , Wasicak JT , Kincaid JF , He Y , Hettinger AM , Huang P , Anderson DJ , Bannon AW , Buckley MJ , Campbell JE , Donnelly-Roberts D , Gunther KL , Kim DJ , Kuntzweiler TA , Sullivan JP , Decker MW , Arneric SP
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2797 , 1998
Abstract :
PubMedSearch : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797
PubMedID: 9873625

Title : Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors - Holladay_1998_J.Med.Chem_41_407
Author(s) : Holladay MW , Wasicak JT , Lin NH , He Y , Ryther KB , Bannon AW , Buckley MJ , Kim DJ , Decker MW , Anderson DJ , Campbell JE , Kuntzweiler TA , Donnelly-Roberts D , Piattoni-Kaplan M , Briggs CA , Williams M , Arneric SP
Ref : Journal of Medicinal Chemistry , 41 :407 , 1998
Abstract :
PubMedSearch : Holladay_1998_J.Med.Chem_41_407
PubMedID: 9484491

Title : Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors - Bannon_1998_Science_279_77
Author(s) : Bannon AW , Decker MW , Holladay MW , Curzon P , Donnelly-Roberts D , Puttfarcken PS , Bitner RS , Diaz A , Dickenson AH , Porsolt RD , Williams M , Arneric SP
Ref : Science , 279 :77 , 1998
Abstract :
PubMedSearch : Bannon_1998_Science_279_77
PubMedID: 9417028

Title : Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist - Lin_1998_Bioorg.Med.Chem.Lett_8_249
Author(s) : Lin NH , Gunn DE , Li Y , He Y , Bai H , Ryther KB , Kuntzweiler T , Donnelly-Roberts D , Anderson DJ , Campbell JE , Sullivan JP , Arneric SP , Holladay MW
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :249 , 1998
Abstract :
PubMedSearch : Lin_1998_Bioorg.Med.Chem.Lett_8_249
PubMedID: 9871663

Title : The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594 - Decker_1998_J.Physiol.Paris_92_221
Author(s) : Decker MW , Curzon P , Holladay MW , Nikkel AL , Bitner RS , Bannon AW , Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Williams M , Arneric SP
Ref : Journal de Physiologie (Paris) , 92 :221 , 1998
Abstract :
PubMedSearch : Decker_1998_J.Physiol.Paris_92_221
PubMedID: 9789812

Title : Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands - Molinari_1998_Eur.J.Pharmacol_347_131
Author(s) : Molinari EJ , Delbono O , Messi ML , Renganathan M , Arneric SP , Sullivan JP , Gopalakrishnan M
Ref : European Journal of Pharmacology , 347 :131 , 1998
Abstract :
PubMedSearch : Molinari_1998_Eur.J.Pharmacol_347_131
PubMedID: 9650859

Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization - Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777
Author(s) : Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Anderson DJ , Campbell JE , Piattoni-Kaplan M , McKenna DG , Wasicak JT , Holladay MW , Williams M , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :777 , 1998
Abstract :
PubMedSearch : Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777
PubMedID: 9580626

Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization - Bannon_1998_J.Pharmacol.Exp.Ther_285_787
Author(s) : Bannon AW , Decker MW , Curzon P , Buckley MJ , Kim DJ , Radek RJ , Lynch JK , Wasicak JT , Lin NH , Arnold WH , Holladay MW , Williams M , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :787 , 1998
Abstract :
PubMedSearch : Bannon_1998_J.Pharmacol.Exp.Ther_285_787
PubMedID: 9580627

Title : Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice - Decker_1998_Eur.J.Pharmacol_346_23
Author(s) : Decker MW , Bannon AW , Buckley MJ , Kim DJ , Holladay MW , Ryther KB , Lin NH , Wasicak JT , Williams M , Arneric SP
Ref : European Journal of Pharmacology , 346 :23 , 1998
Abstract :
PubMedSearch : Decker_1998_Eur.J.Pharmacol_346_23
PubMedID: 9617748

Title : Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys - Prendergast_1998_Psychopharmacology.(Berl)_136_50
Author(s) : Prendergast MA , Jackson WJ , Terry AV, Jr. , Decker MW , Arneric SP , Buccafusco JJ
Ref : Psychopharmacology (Berl) , 136 :50 , 1998
Abstract :
PubMedSearch : Prendergast_1998_Psychopharmacology.(Berl)_136_50
PubMedID: 9537682

Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties - Sullivan_1997_J.Pharmacol.Exp.Ther_283_235
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Xue IC , Piattoni-Kaplan M , Molinari E , Campbell JE , McKenna DG , Gunn DE , Lin NH , Ryther KB , He Y , Holladay MW , Wonnacott S , Williams M , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :235 , 1997
Abstract :
PubMedSearch : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235
PubMedID: 9336329

Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231
Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP
Ref : Pharmacol Biochem Behav , 57 :231 , 1997
Abstract :
PubMedSearch : Briggs_1997_Pharmacol.Biochem.Behav_57_231
PubMedID: 9164577

Title : Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties - Lin_1997_J.Med.Chem_40_385
Author(s) : Lin NH , Gunn DE , Ryther KB , Garvey DS , Donnelly-Roberts D , Decker MW , Brioni JD , Buckley MJ , Rodrigues AD , Marsh KG , Anderson DJ , Buccafusco JJ , Prendergast MA , Sullivan JP , Williams M , Arneric SP , Holladay MW
Ref : Journal of Medicinal Chemistry , 40 :385 , 1997
Abstract :
PubMedSearch : Lin_1997_J.Med.Chem_40_385
PubMedID: 9022806

Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys - Decker_1997_J.Pharmacol.Exp.Ther_283_247
Author(s) : Decker MW , Bannon AW , Curzon P , Gunther KL , Brioni JD , Holladay MW , Lin NH , Li Y , Daanen JF , Buccafusco JJ , Prendergast MA , Jackson WJ , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :247 , 1997
Abstract :
PubMedSearch : Decker_1997_J.Pharmacol.Exp.Ther_283_247
PubMedID: 9336330

Title : Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells - Puttfarcken_1997_J.Neurochem_69_930
Author(s) : Puttfarcken PS , Manelli AM , Arneric SP , Donnelly-Roberts D
Ref : Journal of Neurochemistry , 69 :930 , 1997
Abstract :
PubMedSearch : Puttfarcken_1997_J.Neurochem_69_930
PubMedID: 9282914

Title : Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors - Abreo_1996_J.Med.Chem_39_817
Author(s) : Abreo MA , Lin NH , Garvey DS , Gunn DE , Hettinger AM , Wasicak JT , Pavlik PA , Martin YC , Donnelly-Roberts D , Anderson DJ , Sullivan JP , Williams M , Arneric SP , Holladay MW
Ref : Journal of Medicinal Chemistry , 39 :817 , 1996
Abstract :
PubMedSearch : Abreo_1996_J.Med.Chem_39_817
PubMedID: 8632405

Title : A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand - Sullivan_1996_Neuropharmacol_35_725
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Piattoni-Kaplan M , Campbell JE , McKenna DG , Molinari E , Hettinger AM , Garvey DS , Wasicak JT , Holladay MW , Williams M , Arneric SP
Ref : Neuropharmacology , 35 :725 , 1996
Abstract :
PubMedSearch : Sullivan_1996_Neuropharmacol_35_725
PubMedID: 8887981

Title : Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study - Buisson_1996_J.Neurosci_16_7880
Author(s) : Buisson B , Gopalakrishnan M , Arneric SP , Sullivan JP , Bertrand D
Ref : Journal of Neuroscience , 16 :7880 , 1996
Abstract :
PubMedSearch : Buisson_1996_J.Neurosci_16_7880
PubMedID: 8987816

Title : In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418 - Donnelly-Roberts_1996_Brain.Res_719_36
Author(s) : Donnelly-Roberts D , Xue IC , Arneric SP , Sullivan JP
Ref : Brain Research , 719 :36 , 1996
Abstract :
PubMedSearch : Donnelly-Roberts_1996_Brain.Res_719_36
PubMedID: 8782861

Title : Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor - Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289
Author(s) : Gopalakrishnan M , Monteggia LM , Anderson DJ , Molinari EJ , Piattoni-Kaplan M , Donnelly-Roberts D , Arneric SP , Sullivan JP
Ref : Journal of Pharmacology & Experimental Therapeutics , 276 :289 , 1996
Abstract :
PubMedSearch : Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289
PubMedID: 8558445

Title : Cholinergic channel activators: novel opportunities for the treatment of CNS disorders - Sullivan_1995_Proc.West.Pharmacol.Soc_38_127
Author(s) : Sullivan JP , Decker MW , Donnelly-Roberts D , Brioni JD , Bannon AW , Holladay MW , Anderson DJ , Briggs CA , Williams M , Arneric SP
Ref : Proc West Pharmacol Soc , 38 :127 , 1995
Abstract :
PubMedSearch : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127
PubMedID: 7480004

Title : Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties - Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50
Author(s) : Arneric SP , Sullivan JP , Decker MW , Brioni JD , Bannon AW , Briggs CA , Donnelly-Roberts D , Radek RJ , Marsh KC , Kyncl J , Williams M , Buccafusco JJ
Ref : Alzheimer Disease & Associated Disorders , 9 Suppl 2 :50 , 1995
Abstract :
PubMedSearch : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50
PubMedID: 8534424

Title : Cloning and transient expression of genes encoding the human alpha 4 and beta 2 neuronal nicotinic acetylcholine receptor (nAChR) subunits - Monteggia_1995_Gene_155_189
Author(s) : Monteggia LM , Gopalakrishnan M , Touma E , Idler KB , Nash N , Arneric SP , Sullivan JP , Giordano T
Ref : Gene , 155 :189 , 1995
Abstract :
PubMedSearch : Monteggia_1995_Gene_155_189
PubMedID: 7721089

Title : Functional modulation of human ganglionic-like neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists - Donnelly-Roberts_1995_Biochem.Biophys.Res.Commun_213_657
Author(s) : Donnelly-Roberts D , Arneric SP , Sullivan JP
Ref : Biochemical & Biophysical Research Communications , 213 :657 , 1995
Abstract :
PubMedSearch : Donnelly-Roberts_1995_Biochem.Biophys.Res.Commun_213_657
PubMedID: 7544126

Title : Characterization of [3H]ABT-418: a novel cholinergic channel ligand - Anderson_1995_J.Pharmacol.Exp.Ther_273_1434
Author(s) : Anderson DJ , Williams M , Pauly JR , Raszkiewicz JL , Campbell JE , Rotert G , Surber B , Thomas SB , Wasicak J , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 273 :1434 , 1995
Abstract :
PubMedSearch : Anderson_1995_J.Pharmacol.Exp.Ther_273_1434
PubMedID: 7791118

Title : Stable expression and pharmacological properties of the human alpha 7 nicotinic acetylcholine receptor - Gopalakrishnan_1995_Eur.J.Pharmacol_290_237
Author(s) : Gopalakrishnan M , Buisson B , Touma E , Giordano T , Campbell JE , Hu IC , Donnelly-Roberts D , Arneric SP , Bertrand D , Sullivan JP
Ref : European Journal of Pharmacology , 290 :237 , 1995
Abstract :
PubMedSearch : Gopalakrishnan_1995_Eur.J.Pharmacol_290_237
PubMedID: 7589218

Title : (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization - Arneric_1994_J.Pharmacol.Exp.Ther_270_310
Author(s) : Arneric SP , Sullivan JP , Briggs CA , Donnelly-Roberts D , Anderson DJ , Raszkiewicz JL , Hughes ML , Cadman ED , Adams P , Garvey DS
Ref : Journal of Pharmacology & Experimental Therapeutics , 270 :310 , 1994
Abstract :
PubMedSearch : Arneric_1994_J.Pharmacol.Exp.Ther_270_310
PubMedID: 7518514

Title : Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities -
Author(s) : Garvey DS , Wasicak JT , Decker MW , Brioni JD , Buckley MJ , Sullivan JP , Carrera GM , Holladay MW , Arneric SP , Williams M
Ref : Journal of Medicinal Chemistry , 37 :1055 , 1994
PubMedID: 7909335

Title : Heptyl-physostigmine enhances basal forebrain control of cortical cerebral blood flow - Linville_1992_J.Neurosci.Res_31_573
Author(s) : Linville DG , Giacobini E , Arneric SP
Ref : Journal of Neuroscience Research , 31 :573 , 1992
Abstract :
PubMedSearch : Linville_1992_J.Neurosci.Res_31_573
PubMedID: 1640506

Title : Poster: Effect of cholinesterase inhibitor and exercise on cholineacetyltransferase and acetylcholinesterase activities in rat brain regions -
Author(s) : Babu SR , Arneric SP , Dube SN , Somani SM
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :342 , 1991
PubMedID: