Dierssen_1992_Brain.Res_586_117

Reference

Title : Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats - Dierssen_1992_Brain.Res_586_117
Author(s) : Dierssen M , Marmol F , Vivas NM , Clos MV , Badia A
Ref : Brain Research , 586 :117 , 1992
Abstract :

The possible involvement of beta-adrenoceptor system in the effectiveness of 9-amino-1,2,3,4-tetrahydroacridine (THA) to attenuate retention deficits exhibited by middle-aged rats in a one-trial passive avoidance task has been investigated. THA (2.5 mg.kg-1), injected i.p. after training, induced a significant increase in test step-through latency (STL) in middle-aged rats. Post-training injection of THA reduced basal and isoprenaline stimulated cyclic AMP accumulation in cortex and hippocampus of every group of rats. It is suggested that the effect of THA on memory processes may involve an action on beta-adrenoceptor-linked cyclic AMP accumulation.

PubMedSearch : Dierssen_1992_Brain.Res_586_117
PubMedID: 1380875

Related information

Citations formats

Dierssen M, Marmol F, Vivas NM, Clos MV, Badia A (1992)
Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats
Brain Research 586 :117

Dierssen M, Marmol F, Vivas NM, Clos MV, Badia A (1992)
Brain Research 586 :117