| Title : Potent and selective proline derived dipeptidyl peptidase IV inhibitors - Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151 |
| Author(s) : Edmondson SD , Mastracchio A , Beconi M , Colwell LF, Jr. , Habulihaz B , He H , Kumar S , Leiting B , Lyons KA , Mao A , Marsilio F , Patel RA , Wu JK , Zhu L , Thornberry NA , Weber AE , Parmee ER |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :5151 , 2004 |
|
Abstract :
In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50=1.9 microM). Optimization of 3 led to compound 37, which is among the most potent and selective DPP-IV inhibitors discovered to date. |
| PubMedSearch : Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151 |
| PubMedID: 15380217 |
Edmondson SD, Mastracchio A, Beconi M, Colwell LF, Jr., Habulihaz B, He H, Kumar S, Leiting B, Lyons KA, Mao A, Marsilio F, Patel RA, Wu JK, Zhu L, Thornberry NA, Weber AE, Parmee ER (2004)
Potent and selective proline derived dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett
14 :5151
Edmondson SD, Mastracchio A, Beconi M, Colwell LF, Jr., Habulihaz B, He H, Kumar S, Leiting B, Lyons KA, Mao A, Marsilio F, Patel RA, Wu JK, Zhu L, Thornberry NA, Weber AE, Parmee ER (2004)
Bioorganic & Medicinal Chemistry Lett
14 :5151