| Title : Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes - Eltze_1989_Eur.J.Pharmacol_173_219 |
| Author(s) : Eltze M , Lambrecht G , Mutschler E |
| Ref : European Journal of Pharmacology , 173 :219 , 1989 |
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Abstract :
The affinity of cyproheptadine for different muscarinic receptor subtypes was investigated in vitro by functional experiments in field-stimulated vas deferens of the rabbit (ganglionic M1- and cardiac M2-receptors) and in guinea-pig ileum (smooth muscle M3-receptors). Cyproheptadine displayed high but similar affinity for all muscarinic receptor subtypes studied (pA2 = 7.99-8.02). In contrast, (+)-telenzepine (M1 over M2 and M3), and for mefurtramine (M2 over M3 and M1) were found to be selective. |
| PubMedSearch : Eltze_1989_Eur.J.Pharmacol_173_219 |
| PubMedID: 2625138 |
Eltze M, Lambrecht G, Mutschler E (1989)
Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes
European Journal of Pharmacology
173 :219
Eltze M, Lambrecht G, Mutschler E (1989)
European Journal of Pharmacology
173 :219