| Title : Neurotransmitters and second messengers in aging and Alzheimer's disease - Francis_1993_Ann.N.Y.Acad.Sci_695_19 |
| Author(s) : Francis PT , Webster MT , Chessell IP , Holmes C , Stratmann GC , Procter AW , Cross AJ , Green AR , Bowen DM |
| Ref : Annals of the New York Academy of Sciences , 695 :19 , 1993 |
|
Abstract :
A substantial loss of cortical cholinergic nerve endings, along with a much more circumscribed cortical degeneration of pyramidal neurons, almost certainly causes glutamatergic hypoactivity in live Alzheimer's patients. These selective pathologies are discussed in terms of therapy. An additional effect of some proposed treatments is emerging as there is evidence that processing pathways for beta-amyloid precursor proteins in cortical pyramidal neurons, a target cell for acetylcholine, are affected by neuronal activity. |
| PubMedSearch : Francis_1993_Ann.N.Y.Acad.Sci_695_19 |
| PubMedID: 7902054 |
Francis PT, Webster MT, Chessell IP, Holmes C, Stratmann GC, Procter AW, Cross AJ, Green AR, Bowen DM (1993)
Neurotransmitters and second messengers in aging and Alzheimer's disease
Annals of the New York Academy of Sciences
695 :19
Francis PT, Webster MT, Chessell IP, Holmes C, Stratmann GC, Procter AW, Cross AJ, Green AR, Bowen DM (1993)
Annals of the New York Academy of Sciences
695 :19