Gardiner_2012_PLoS.Pathog_8_e1002952

Reference

Title : Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts - Gardiner_2012_PLoS.Pathog_8_e1002952
Author(s) : Gardiner DM , McDonald MC , Covarelli L , Solomon PS , Rusu AG , Marshall M , Kazan K , Chakraborty S , McDonald BA , Manners JM
Ref : PLoS Pathog , 8 :e1002952 , 2012
Abstract :

Comparative analyses of pathogen genomes provide new insights into how pathogens have evolved common and divergent virulence strategies to invade related plant species. Fusarium crown and root rots are important diseases of wheat and barley world-wide. In Australia, these diseases are primarily caused by the fungal pathogen Fusarium pseudograminearum. Comparative genomic analyses showed that the F. pseudograminearum genome encodes proteins that are present in other fungal pathogens of cereals but absent in non-cereal pathogens. In some cases, these cereal pathogen specific genes were also found in bacteria associated with plants. Phylogenetic analysis of selected F. pseudograminearum genes supported the hypothesis of horizontal gene transfer into diverse cereal pathogens. Two horizontally acquired genes with no previously known role in fungal pathogenesis were studied functionally via gene knockout methods and shown to significantly affect virulence of F. pseudograminearum on the cereal hosts wheat and barley. Our results indicate using comparative genomics to identify genes specific to pathogens of related hosts reveals novel virulence genes and illustrates the importance of horizontal gene transfer in the evolution of plant infecting fungal pathogens.

PubMedSearch : Gardiner_2012_PLoS.Pathog_8_e1002952
PubMedID: 23028337
Gene_locus related to this paper: gibze-a8w610 , gibze-i1rda9 , gibze-i1rdk7 , gibze-i1rec8 , gibze-i1rgs0 , gibze-i1rgy0 , gibze-i1rh52 , gibze-i1rig9 , gibze-i1rip5 , gibze-i1rpg6 , gibze-i1rsg2 , gibze-i1rv36 , gibze-i1rxm5 , gibze-i1rxp8 , gibze-i1rxv5 , gibze-i1s3j9 , gibze-i1s8i8 , gibze-i1s9x4 , gibze-q4huy1 , fuspc-k3u8z2 , fuspc-k3vzd3 , fuspc-k3w1u7 , gibza-a0a016pl96 , fuspc-k3ufi3 , gibze-i1rkc4 , fuspc-fdb26 , fuspc-w4935

Related information

Gene_locus gibze-a8w610    gibze-i1rda9    gibze-i1rdk7    gibze-i1rec8    gibze-i1rgs0    gibze-i1rgy0    gibze-i1rh52    gibze-i1rig9    gibze-i1rip5    gibze-i1rpg6    gibze-i1rsg2    gibze-i1rv36    gibze-i1rxm5    gibze-i1rxp8    gibze-i1rxv5    gibze-i1s3j9    gibze-i1s8i8    gibze-i1s9x4    gibze-q4huy1    fuspc-k3u8z2    fuspc-k3vzd3    fuspc-k3w1u7    gibza-a0a016pl96    fuspc-k3ufi3    gibze-i1rkc4    fuspc-fdb26    fuspc-w4935
Gene_locus_frgt gibze-a8w610    gibze-i1rda9    gibze-i1rdk7    gibze-i1rec8    gibze-i1rgs0    gibze-i1rgy0    gibze-i1rh52    gibze-i1rig9    gibze-i1rip5    gibze-i1rpg6    gibze-i1rsg2    gibze-i1rv36    gibze-i1rxm5    gibze-i1rxp8    gibze-i1rxv5    gibze-i1s3j9    gibze-i1s8i8    gibze-i1s9x4    gibze-q4huy1    fuspc-k3u8z2    fuspc-k3vzd3    fuspc-k3w1u7    gibza-a0a016pl96    fuspc-k3ufi3    gibze-i1rkc4    fuspc-fdb26    fuspc-w4935    gibze-i1s445

Citations formats

Gardiner DM, McDonald MC, Covarelli L, Solomon PS, Rusu AG, Marshall M, Kazan K, Chakraborty S, McDonald BA, Manners JM (2012)
Comparative pathogenomics reveals horizontally acquired novel virulence genes in fungi infecting cereal hosts
PLoS Pathog 8 :e1002952

Gardiner DM, McDonald MC, Covarelli L, Solomon PS, Rusu AG, Marshall M, Kazan K, Chakraborty S, McDonald BA, Manners JM (2012)
PLoS Pathog 8 :e1002952