| Title : miR-124 represses ROCK1 expression to promote neurite elongation through activation of the PI3K\/Akt signal pathway - Gu_2014_J.Mol.Neurosci_52_156 |
| Author(s) : Gu X , Meng S , Liu S , Jia C , Fang Y , Li S , Fu C , Song Q , Lin L , Wang X |
| Ref : Journal of Molecular Neuroscience , 52 :156 , 2014 |
|
Abstract :
Recent studies have demonstrated an important role for miR-124, the most abundant and well-conserved brain-specific microRNA(miRNA), in promoting neurite outgrowth and elongation during neuronal differentiation. This miRNA's target genes and the mechanisms that execute this role remain unclear. In this study, we identified ROCK1, a small GTPase Rho kinase, as a direct target of miR-124 for regulating neurite elongation. miR-124 significantly inhibited ROCK1 expression in M17 cells. Inhibiting ROCK1 promoted neurite elongation, and the overexpression of ROCK1 strongly repressed the neurite elongation-enhancing effect of miR-124 in M17 cells. We determined that Akt functions as a novel ROCK1 downstream effector in regulating neurite outgrowth and elongation. |
| PubMedSearch : Gu_2014_J.Mol.Neurosci_52_156 |
| PubMedID: 24338057 |
Gu X, Meng S, Liu S, Jia C, Fang Y, Li S, Fu C, Song Q, Lin L, Wang X (2014)
miR-124 represses ROCK1 expression to promote neurite elongation through activation of the PI3K\/Akt signal pathway
Journal of Molecular Neuroscience
52 :156
Gu X, Meng S, Liu S, Jia C, Fang Y, Li S, Fu C, Song Q, Lin L, Wang X (2014)
Journal of Molecular Neuroscience
52 :156