Guo_2018_Science_362_343

Reference

Title : The opium poppy genome and morphinan production - Guo_2018_Science_362_343
Author(s) : Guo L , Winzer T , Yang X , Li Y , Ning Z , He Z , Teodor R , Lu Y , Bowser TA , Graham IA , Ye K
Ref : Science , 362 :343 , 2018
Abstract : Morphinan-based painkillers are derived from opium poppy (Papaver somniferum L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the STORR gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.
ESTHER : Guo_2018_Science_362_343
PubMedSearch : Guo_2018_Science_362_343
PubMedID: 30166436
Gene_locus related to this paper: papso-a0a4y7jba3 , papso-a0a4y7jac2 , papso-a0a4y7kic2

Related information

Gene_locus related to this paper: papso-a0a4y7jba3 , papso-a0a4y7jac2 , papso-a0a4y7kic2

Citations formats

Guo L, Winzer T, Yang X, Li Y, Ning Z, He Z, Teodor R, Lu Y, Bowser TA, Graham IA, Ye K (2018)
The opium poppy genome and morphinan production
Science 362 :343

Guo L, Winzer T, Yang X, Li Y, Ning Z, He Z, Teodor R, Lu Y, Bowser TA, Graham IA, Ye K (2018)
Science 362 :343