| Title : Divergent synthesis of organophosphate [(11)C]VX- and [(11)C]Sarin-surrogates from a common set of starting materials - Hayes_2019_Appl.Radiat.Isot_151_182 |
| Author(s) : Hayes TR , Blecha JE , Thompson CM , Gerdes JM , VanBrocklin HF |
| Ref : Appl Radiat Isot , 151 :182 , 2019 |
|
Abstract :
Radiolabeled 1-[(11)C]ethyl, 4-nitrophenyl methylphosphonate (VX surrogate) and 2-[(11)C]-propanyl, 4-nitrophenyl methylphosphonate (sarin surrogate) were developed as organophosphate (OP) tracers. The [(11)C]ethyl- and [(11)C]isopropyl-iodide radiolabeled synthons were obtained by temperature controlled, in loop reactions of [(11)C]CO2 with MeMgBr followed by reduction with LiAlH4, then reaction with HI. Distillation of the [(11)C]alkyl iodides into a solution of hydrogen (4-nitrophenyl)methylphosphonate and cesium carbonate afforded the desired tracers in >95% radiochemical purity, yields from [(11)C]CO2 of 1-3% and 1.7-15.1 GBq/mmol molar activities. |
| PubMedSearch : Hayes_2019_Appl.Radiat.Isot_151_182 |
| PubMedID: 31202183 |
Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF (2019)
Divergent synthesis of organophosphate [(11)C]VX- and [(11)C]Sarin-surrogates from a common set of starting materials
Appl Radiat Isot
151 :182
Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF (2019)
Appl Radiat Isot
151 :182