Title : Counteracting poisoning with chemical warfare nerve agents - Hrvat_2020_Arh.Hig.Rada.Toksikol_71_266
Author(s) : Hrvat NM , Kovarik Z
Ref : Arh Hig Rada Toksikol , 71 :266 , 2020
Abstract : Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. In severe cases, subsequent desensitisation of the receptors results in hypoxia, vasodepression, and respiratory arrest, followed by death. Prompt action is therefore critical to improve the chances of victim's survival and recovery. Standard therapy of NA poisoning generally involves administration of anticholinergic atropine and an oxime reactivator of phosphylated AChE. Anticholinesterase compounds or NA bioscavengers can also be applied to preserve native AChE from inhibition. With this review of 70 years of research we aim to present current and potential approaches to counteracting NA poisoning.
ESTHER : Hrvat_2020_Arh.Hig.Rada.Toksikol_71_266
PubMedSearch : Hrvat_2020_Arh.Hig.Rada.Toksikol_71_266
PubMedID: 33410774

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Citations formats

Hrvat NM, Kovarik Z (2020)
Counteracting poisoning with chemical warfare nerve agents
Arh Hig Rada Toksikol 71 :266

Hrvat NM, Kovarik Z (2020)
Arh Hig Rada Toksikol 71 :266