Full name : Macek Hrvat Nikolina
First name : Nikolina
Mail : Institute for Medical Research and Occupational Health\; Ksaverska cesta 2\; HR-10000 Zagreb
Zip Code :
City :
Country : Croatia
Email : nmacek@imi.hr
Phone : +38514673188
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Website :
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Comment
| Title : N,N'-dibenzyl imidazolium oximes are potent reactivators of organophosphate-inhibited human butyrylcholinesterase - Kolic_2026_Eur.J.Med.Chem_313_118895 |
| Author(s) : Kolic D , Divjak T , Sinko G , Spahic Z , Ramic A , Lulic AM , Katalinic M , Macek Hrvat N , Primozic I , Kovarik Z |
| Ref : Eur Journal of Medicinal Chemistry , 313 :118895 , 2026 |
| Abstract : |
| PubMedSearch : Kolic_2026_Eur.J.Med.Chem_313_118895 |
| PubMedID: 42070449 |
| Title : Outlining the A-Series of Organophosphorus Compounds: Cholinesterase Inhibition, Reactivation, Cytotoxicity, and Acute Toxicity in Mice - Kovarik_2025_Chem.Biol.Interact_15ChEPon__111762 |
| Author(s) : Kovarik Z , Kolic D , Cadez T , Sinko G , Tuksar P , Zorbaz T , Curty C , Macek Hrvat N |
| Ref : Chemico-Biological Interactions , :111762 , 2025 |
| Abstract : |
| PubMedSearch : Kovarik_2025_Chem.Biol.Interact_15ChEPon__111762 |
| PubMedID: 41038428 |
| Title : The ionizing zwitterionic oxime antidote attenuates gliosis in mice exposed to sarin - Macek Hrvat_2025_Chem.Biol.Interact_15ChEPon_421_111767 |
| Author(s) : Macek Hrvat N , Puljko B , Sit RK , Ilic K , Kolic D , Mlinac-Jerkovic K , Kalanj-Bognar S , Radic Z , Sharpless BK , Taylor P , Kovarik Z |
| Ref : Chemico-Biological Interactions , 421 :111767 , 2025 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2025_Chem.Biol.Interact_15ChEPon_421_111767 |
| PubMedID: 41038430 |
| Title : Photochemistry-driven design of small molecule cholinesterase ligands - Skoric_2025_Chem.Biol.Interact_15ChEPon_420_111703 |
| Author(s) : Skoric I , Sviben M , Mlakic M , Cadez T , Macek Hrvat N , Kovarik Z |
| Ref : Chemico-Biological Interactions , 420 :111703 , 2025 |
| Abstract : |
| PubMedSearch : Skoric_2025_Chem.Biol.Interact_15ChEPon_420_111703 |
| PubMedID: 40816573 |
| Title : Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging - Cadez_2025_Arch.Toxicol__ |
| Author(s) : Cadez T , Macek Hrvat N , Sinko G , Kalisiak J , Radic Z , Fokin VV , Sharpless KB , Taylor P , Kovarik Z |
| Ref : Archives of Toxicology , : , 2025 |
| Abstract : |
| PubMedSearch : Cadez_2025_Arch.Toxicol__ |
| PubMedID: 40032685 |
| Title : Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults - Kovarik_2023_J.Neurochem_17thISCM_ |
| Author(s) : Kovarik Z , Moshitzky G , Macek Hrvat N , Soreq H |
| Ref : Journal of Neurochemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Kovarik_2023_J.Neurochem_17thISCM_ |
| PubMedID: 37429600 |
| Title : Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents - Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| Author(s) : Zorbaz T , Malinak D , Hofmanova T , Marakovic N , Zunec S , Macek Hrvat N , Andrys R , Psotka M , Zandona A , Svobodova J , Prchal L , Fingler S , Katalinic M , Kovarik Z , Musilek K |
| Ref : Eur Journal of Medicinal Chemistry , 238 :114377 , 2022 |
| Abstract : |
| PubMedSearch : Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| PubMedID: 35526478 |
| Title : Redistribution of gangliosides accompanies thermally induced Na(+), K(+)-ATPase activity alternation and submembrane localisation in mouse brain - |
| Author(s) : Puljko B , Stojanovic M , Ilic K , Macek Hrvat N , Zovko A , Damjanovic V , Mlinac-Jerkovic K , Kalanj-Bognar S |
| Ref : Biochimica & Biophysica Acta Biomembr , 1863 :183475 , 2021 |
| PubMedID: 32956659 |
| Title : Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning - Zorbaz_2020_ACS.Chem.Neurosci__ |
| Author(s) : Zorbaz T , Misetic P , Probst N , Zunec S , Zandona A , Mendas G , Micek V , Macek Hrvat N , Katalinic M , Braiki A , Jean L , Renard PY , Gabelica Markovic V , Kovarik Z |
| Ref : ACS Chem Neurosci , : , 2020 |
| Abstract : |
| PubMedSearch : Zorbaz_2020_ACS.Chem.Neurosci__ |
| PubMedID: 32105443 |
| Title : Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors - Cadez_2020_Molecules_25_ |
| Author(s) : Cadez T , Grgicevic A , Ahmetovic R , Baric D , Macek Hrvat N , Kovarik Z , Skoric I |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : Cadez_2020_Molecules_25_ |
| PubMedID: 33105595 |
| Title : Counteracting poisoning with chemical warfare nerve agents - Hrvat_2020_Arh.Hig.Rada.Toksikol_71_266 |
| Author(s) : Macek Hrvat N , Kovarik Z |
| Ref : Arh Hig Rada Toksikol , 71 :266 , 2020 |
| Abstract : |
| PubMedSearch : Hrvat_2020_Arh.Hig.Rada.Toksikol_71_266 |
| PubMedID: 33410774 |
| Title : Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants - Kovarik_2020_Neuropharmacol__108111 |
| Author(s) : Kovarik Z , Macek Hrvat N |
| Ref : Neuropharmacology , :108111 , 2020 |
| Abstract : |
| PubMedSearch : Kovarik_2020_Neuropharmacol__108111 |
| PubMedID: 32333945 |
| Title : Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives - Sagud_2020_J.Enzyme.Inhib.Med.Chem_35_460 |
| Author(s) : Sagud I , Macek Hrvat N , Grgicevic A , Cadez T , Hodak J , Dragojevic M , Lasic K , Kovarik Z , Skoric I |
| Ref : J Enzyme Inhib Med Chem , 35 :460 , 2020 |
| Abstract : |
| PubMedSearch : Sagud_2020_J.Enzyme.Inhib.Med.Chem_35_460 |
| PubMedID: 31899981 |
| Title : Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases - Macek Hrvat_2019_Toxicol.Lett_321_83 |
| Author(s) : Macek Hrvat N , Kalisiak J , Sinko G , Radic Z , Sharpless KB , Taylor P , Kovarik Z |
| Ref : Toxicol Lett , 321 :83 , 2019 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2019_Toxicol.Lett_321_83 |
| PubMedID: 31863869 |
| Title : Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase - Kovarik_2019_Toxicol.Appl.Pharmacol_372_40 |
| Author(s) : Kovarik Z , Macek Hrvat N , Kalisiak J , Katalinic M , Sit RK , Zorbaz T , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Toxicol Appl Pharmacol , 372 :40 , 2019 |
| Abstract : |
| PubMedSearch : Kovarik_2019_Toxicol.Appl.Pharmacol_372_40 |
| PubMedID: 30978400 |
| Gene_locus related to this paper: human-ACHE |
| Title : Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase - Kovarik_2019_Chemistry_25_4100 |
| Author(s) : Kovarik Z , Kalisiak J , Macek Hrvat N , Katalinic M , Zorbaz T , Zunec S , Green C , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemistry , 25 :4100 , 2019 |
| Abstract : |
| PubMedSearch : Kovarik_2019_Chemistry_25_4100 |
| PubMedID: 30458057 |
| Title : Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure - Sit_2018_J.Pharmacol.Exp.Ther_367_363 |
| Author(s) : Sit RK , Kovarik Z , Macek Hrvat N , Zunec S , Green C , Fokin VV , Sharpless KB , Radic Z , Taylor P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 367 :363 , 2018 |
| Abstract : |
| PubMedSearch : Sit_2018_J.Pharmacol.Exp.Ther_367_363 |
| PubMedID: 30190337 |
| Title : Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations - Katalinic_2018_Toxicology_406-407_104 |
| Author(s) : Katalinic M , Sinko G , Macek Hrvat N , Zorbaz T , Bosak A , Kovarik Z |
| Ref : Toxicology , 406-407 :104 , 2018 |
| Abstract : |
| PubMedSearch : Katalinic_2018_Toxicology_406-407_104 |
| PubMedID: 29772260 |
| Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753 |
| Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K |
| Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018 |
| Abstract : |
| PubMedSearch : Zorbaz_2018_J.Med.Chem_61_10753 |
| PubMedID: 30383374 |
| Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675 |
| Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY |
| Ref : Chemistry , 24 :9675 , 2018 |
| Abstract : |
| PubMedSearch : Zorbaz_2018_Chemistry_24_9675 |
| PubMedID: 29672968 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation - Macek Hrvat_2018_Toxicol.Lett_293_222 |
| Author(s) : Macek Hrvat N , Zorbaz T , Sinko G , Kovarik Z |
| Ref : Toxicol Lett , 293 :222 , 2018 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2018_Toxicol.Lett_293_222 |
| PubMedID: 29180286 |
| Title : A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers - Katalinic_2016_Toxicol.Appl.Pharmacol_310_195 |
| Author(s) : Katalinic M , Macek Hrvat N , Baumann K , Morasi Pipercic S , Makaric S , Tomic S , Jovic O , Hrenar T , Milicevic A , Jelic D , Zunec S , Primozic I , Kovarik Z |
| Ref : Toxicol Appl Pharmacol , 310 :195 , 2016 |
| Abstract : |
| PubMedSearch : Katalinic_2016_Toxicol.Appl.Pharmacol_310_195 |
| PubMedID: 27654152 |
| Title : HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants - Macek Hrvat_2016_Chem.Biol.Interact_259_148 |
| Author(s) : Macek Hrvat N , Zunec S , Taylor P , Radic Z , Kovarik Z |
| Ref : Chemico-Biological Interactions , 259 :148 , 2016 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2016_Chem.Biol.Interact_259_148 |
| PubMedID: 27083141 |
| Gene_locus related to this paper: human-ACHE |
| Title : Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning - Katalinic_2015_Arh.Hig.Rada.Toksikol_66_291 |
| Author(s) : Katalinic M , Macek Hrvat N , Karasova JZ , Misik J , Kovarik Z |
| Ref : Arh Hig Rada Toksikol , 66 :291 , 2015 |
| Abstract : |
| PubMedSearch : Katalinic_2015_Arh.Hig.Rada.Toksikol_66_291 |
| PubMedID: 26751861 |
| Title : Catalytic Soman Scavenging by the Y337A\/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes - Kovarik_2015_Chem.Res.Toxicol_28_1036 |
| Author(s) : Kovarik Z , Macek Hrvat N , Katalinic M , Sit RK , Paradyse A , Zunec S , Musilek K , Fokin VV , Taylor P , Radic Z |
| Ref : Chemical Research in Toxicology , 28 :1036 , 2015 |
| Abstract : |
| PubMedSearch : Kovarik_2015_Chem.Res.Toxicol_28_1036 |
| PubMedID: 25835984 |
| Title : Centrally acting oximes in reactivation of tabun-phosphoramidated AChE - Kovarik_2013_Chem.Biol.Interact_203_77 |
| Author(s) : Kovarik Z , Macek Hrvat N , Sit RK , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 203 :77 , 2013 |
| Abstract : |
| PubMedSearch : Kovarik_2013_Chem.Biol.Interact_203_77 |
| PubMedID: 22960624 |