Kovarik Z

General

Full name : Kovarik Zrinka

First name : Zrinka

Mail : Institute for Medical Research and Occupational Health\; Ksaverska cesta 2\; HR-10000 Zagreb. +38514682555

Zip Code :

City :

Country : Croatia

Email : zkovarik@imi.hr

Phone : +38514673188

Fax :

Website : \/\/www.imi.hr\/organizacija.php?id=3&lan=EN&person=121

Directory :

References (91)

Title : Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase - Kolic_2024_Arh.Hig.Rada.Toksikol_75_76
Author(s) : Kolic D , Pehar V , Kovarik Z
Ref : Arh Hig Rada Toksikol , 75 :76 , 2024
PubMedID: 38548375

Title : Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults - Kovarik_2023_J.Neurochem_17thISCM_
Author(s) : Kovarik Z , Moshitzky G , Macek Hrvat N , Soreq H
Ref : Journal of Neurochemistry , : , 2023
PubMedID: 37429600

Title : Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease - Matosevic_2023_Chem.Biol.Interact_14ChEPon_382_110620
Author(s) : Matosevic A , Opsenica DM , Spasic M , Marakovic N , Zandona A , Zunec S , Bartolic M , Kovarik Z , Bosak A
Ref : Chemico-Biological Interactions , 382 :110620 , 2023
PubMedID: 37406982

Title : Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases - Pehar_2023_Chem.Biol.Interact_14ChEPon_379_110506
Author(s) : Pehar V , Kolic D , Zandona A , Sinko G , Katalinic M , Stepanic V , Kovarik Z
Ref : Chemico-Biological Interactions , 379 :110506 , 2023
PubMedID: 37141932

Title : Recent advances in cholinergic mechanisms: A preface for the ISCM2022 special issue - Kovarik_2023_J.Neurochem_17thISCM__
Author(s) : Kovarik Z , Soreq H
Ref : Journal of Neurochemistry , : , 2023
PubMedID: 38082541

Title : Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease - Matosevic_2022_Pharmaceuticals.(Basel)_15_
Author(s) : Matosevic A , Knezevic A , Zandona A , Marakovic N , Kovarik Z , Bosak A
Ref : Pharmaceuticals (Basel) , 15 : , 2022
PubMedID: 36297332

Title : Newly Scheduled Carbamate Compounds: A synopsis of their properties and development, and considerations for the scientific community - Palermo_2022_Toxicology__153322
Author(s) : Palermo G , Kovarik Z , Hotchkiss PJ
Ref : Toxicology , :153322 , 2022
PubMedID: 36115648

Title : Potential of Vitamin B6 Dioxime Analogues to Act as Cholinesterase Ligands - Gaso-Sokac_2022_Int.J.Mol.Sci_23_
Author(s) : Gaso-Sokac D , Zandona A , Roca S , Vikic-Topic D , Lihtar G , Marakovic N , Busic V , Kovarik Z , Katalinic M
Ref : Int J Mol Sci , 23 : , 2022
PubMedID: 36362178

Title : Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents - Zorbaz_2022_Eur.J.Med.Chem_238_114377
Author(s) : Zorbaz T , Malinak D , Hofmanova T , Marakovic N , Zunec S , Hrvat NM , Andrys R , Psotka M , Zandona A , Svobodova J , Prchal L , Fingler S , Katalinic M , Kovarik Z , Musilek K
Ref : Eur Journal of Medicinal Chemistry , 238 :114377 , 2022
PubMedID: 35526478

Title : New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases - Mlakic_2021_Pharmaceuticals.(Basel)_14_
Author(s) : Mlakic M , Cadez T , Baric D , Pucek I , Ratkovic A , Marinic , Lasic K , Kovarik Z , Skoric I
Ref : Pharmaceuticals (Basel) , 14 : , 2021
PubMedID: 34832929

Title : Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical - Taylor_2021_J.Neurochem__
Author(s) : Taylor P , Shong YJ , Samskey N , Ho KY , Radic Z , Fenical W , Sharpless KB , Kovarik Z , Andrea Camacho-Hernandez G
Ref : Journal of Neurochemistry , : , 2021
PubMedID: 33638151

Title : Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase - Cadez_2021_Sci.Rep_11_21486
Author(s) : Cadez T , Kolic D , Sinko G , Kovarik Z
Ref : Sci Rep , 11 :21486 , 2021
PubMedID: 34728713

Title : Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning - Zorbaz_2020_ACS.Chem.Neurosci__
Author(s) : Zorbaz T , Misetic P , Probst N , Zunec S , Zandona A , Mendas G , Micek V , Macek Hrvat N , Katalinic M , Braiki A , Jean L , Renard PY , Gabelica Markovic V , Kovarik Z
Ref : ACS Chem Neurosci , : , 2020
PubMedID: 32105443

Title : Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives - Sagud_2020_J.Enzyme.Inhib.Med.Chem_35_460
Author(s) : Sagud I , Macek Hrvat N , Grgicevic A , Cadez T , Hodak J , Dragojevic M , Lasic K , Kovarik Z , Skoric I
Ref : J Enzyme Inhib Med Chem , 35 :460 , 2020
PubMedID: 31899981

Title : Targeting organophosphorus compounds poisoning by novel quinuclidine-3 oximes: development of butyrylcholinesterase-based bioscavengers - Zandona_2020_Arch.Toxicol_94_3157
Author(s) : Zandona A , Katalinic M , Sinko G , Radman Kastelic A , Primozic I , Kovarik Z
Ref : Archives of Toxicology , 94 :3157 , 2020
PubMedID: 32583098

Title : Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants - Kovarik_2020_Neuropharmacol__108111
Author(s) : Kovarik Z , Hrvat NM
Ref : Neuropharmacology , :108111 , 2020
PubMedID: 32333945

Title : Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases - Marakovic_2020_Biochem.J_477_2771
Author(s) : Marakovic N , Knezevic A , Roncevic I , Brazzolotto X , Kovarik Z , Sinko G
Ref : Biochemical Journal , 477 :2771 , 2020
PubMedID: 32639532
Gene_locus related to this paper: human-BCHE

Title : Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors - Cadez_2020_Molecules_25_
Author(s) : Cadez T , Grgicevic A , Ahmetovic R , Baric D , Hrvat NM , Kovarik Z , Skoric I
Ref : Molecules , 25 : , 2020
PubMedID: 33105595

Title : Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates - Bosak_2020_Molecules_25_
Author(s) : Bosak A , Bavec A , Konte T , Sinko G , Kovarik Z , Golicnik M
Ref : Molecules , 25 : , 2020
PubMedID: 31947900

Title : Counteracting poisoning with chemical warfare nerve agents - Hrvat_2020_Arh.Hig.Rada.Toksikol_71_266
Author(s) : Hrvat NM , Kovarik Z
Ref : Arh Hig Rada Toksikol , 71 :266 , 2020
PubMedID: 33410774

Title : Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase - Bosak_2019_Chem.Biol.Interact_13ChEPon_308_101
Author(s) : Bosak A , Opsenica DM , Sinko G , Zlatar M , Kovarik Z
Ref : Chemico-Biological Interactions , 308 :101 , 2019
PubMedID: 31100281

Title : Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases - Macek Hrvat_2019_Toxicol.Lett_321_83
Author(s) : Macek Hrvat N , Kalisiak J , Sinko G , Radic Z , Sharpless KB , Taylor P , Kovarik Z
Ref : Toxicol Lett , 321 :83 , 2019
PubMedID: 31863869

Title : Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase - Kovarik_2019_Chemistry_25_4100
Author(s) : Kovarik Z , Kalisiak J , Hrvat NM , Katalinic M , Zorbaz T , Zunec S , Green C , Radic Z , Fokin VV , Sharpless KB , Taylor P
Ref : Chemistry , 25 :4100 , 2019
PubMedID: 30458057

Title : Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure - Taylor_2019_Chem.Biol.Interact_13ChEPon_308_194
Author(s) : Taylor P , Yan-Jye S , Momper J , Hou W , Camacho-Hernandez GA , Radic Z , Rosenberg YJ , Kovarik Z , Sit R , Sharpless KB
Ref : Chemico-Biological Interactions , 308 :194 , 2019
PubMedID: 31100277

Title : Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes - Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16
Author(s) : Zorbaz T , Malinak D , Kuca K , Musilek K , Kovarik Z
Ref : Chemico-Biological Interactions , 307 :16 , 2019
PubMedID: 31004594

Title : Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase - Kovarik_2019_Toxicol.Appl.Pharmacol_372_40
Author(s) : Kovarik Z , Macek Hrvat N , Kalisiak J , Katalinic M , Sit RK , Zorbaz T , Radic Z , Fokin VV , Sharpless KB , Taylor P
Ref : Toxicol Appl Pharmacol , 372 :40 , 2019
PubMedID: 30978400
Gene_locus related to this paper: human-ACHE

Title : The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation - Macek Hrvat_2018_Toxicol.Lett_293_222
Author(s) : Macek Hrvat N , Zorbaz T , Sinko G , Kovarik Z
Ref : Toxicol Lett , 293 :222 , 2018
PubMedID: 29180286

Title : Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure - Sit_2018_J.Pharmacol.Exp.Ther_367_363
Author(s) : Sit RK , Kovarik Z , Macek Hrvat N , Zunec S , Green C , Fokin VV , Sharpless KB , Radic Z , Taylor P
Ref : Journal of Pharmacology & Experimental Therapeutics , 367 :363 , 2018
PubMedID: 30190337

Title : Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold - Bosak_2018_PLoS.One_13_e0205193
Author(s) : Bosak A , Ramic A , Smidlehner T , Hrenar T , Primozic I , Kovarik Z
Ref : PLoS ONE , 13 :e0205193 , 2018
PubMedID: 30289893

Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675
Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY
Ref : Chemistry , 24 :9675 , 2018
PubMedID: 29672968
Gene_locus related to this paper: torca-ACHE

Title : Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations - Katalinic_2018_Toxicology_406-407_104
Author(s) : Katalinic M , Sinko G , Macek Hrvat N , Zorbaz T , Bosak A , Kovarik Z
Ref : Toxicology , 406-407 :104 , 2018
PubMedID: 29772260

Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753
Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K
Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018
PubMedID: 30383374

Title : Resorcinol-, catechol- and saligenin-based bronchodilating beta2-agonists as inhibitors of human cholinesterase activity - Bosak_2017_J.Enzyme.Inhib.Med.Chem_32_789
Author(s) : Bosak A , Knezevic A , Gazic Smilovic I , Sinko G , Kovarik Z
Ref : J Enzyme Inhib Med Chem , 32 :789 , 2017
PubMedID: 28573890

Title : New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds - Katalinic_2017_Molecules_22_
Author(s) : Katalinic M , Zandona A , Ramic A , Zorbaz T , Primozic I , Kovarik Z
Ref : Molecules , 22 : , 2017
PubMedID: 28737687

Title : HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants - Macek Hrvat_2016_Chem.Biol.Interact_259_148
Author(s) : Macek Hrvat N , Zunec S , Taylor P , Radic Z , Kovarik Z
Ref : Chemico-Biological Interactions , 259 :148 , 2016
PubMedID: 27083141
Gene_locus related to this paper: human-ACHE

Title : A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers - Katalinic_2016_Toxicol.Appl.Pharmacol_310_195
Author(s) : Katalinic M , Macek Hrvat N , Baumann K , Morasi Pipercic S , Makaric S , Tomic S , Jovic O , Hrenar T , Milicevic A , Jelic D , Zunec S , Primozic I , Kovarik Z
Ref : Toxicol Appl Pharmacol , 310 :195 , 2016
PubMedID: 27654152

Title : Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds - Busic_2016_Toxicol.Lett_262_114
Author(s) : Busic V , Katalinic M , Sinko G , Kovarik Z , Gaso-Sokac D
Ref : Toxicol Lett , 262 :114 , 2016
PubMedID: 27693733

Title : Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases - Marakovic_2016_Chem.Biol.Interact_259_122
Author(s) : Marakovic N , Knezevic A , Vinkovic V , Kovarik Z , Sinko G
Ref : Chemico-Biological Interactions , 259 :122 , 2016
PubMedID: 27238725

Title : Catalytic Soman Scavenging by the Y337A\/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes - Kovarik_2015_Chem.Res.Toxicol_28_1036
Author(s) : Kovarik Z , Macek Hrvat N , Katalinic M , Sit RK , Paradyse A , Zunec S , Musilek K , Fokin VV , Taylor P , Radic Z
Ref : Chemical Research in Toxicology , 28 :1036 , 2015
PubMedID: 25835984

Title : Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning - Katalinic_2015_Arh.Hig.Rada.Toksikol_66_291
Author(s) : Katalinic M , Macek Hrvat N , Karasova JZ , Misik J , Kovarik Z
Ref : Arh Hig Rada Toksikol , 66 :291 , 2015
PubMedID: 26751861

Title : Centrally acting oximes in reactivation of tabun-phosphoramidated AChE - Kovarik_2013_Chem.Biol.Interact_203_77
Author(s) : Kovarik Z , Macek Hrvat N , Sit RK , Radic Z , Fokin VV , Sharpless KB , Taylor P
Ref : Chemico-Biological Interactions , 203 :77 , 2013
PubMedID: 22960624

Title : Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes - Radic_2013_Biochem.J_450_231
Author(s) : Radic Z , Dale T , Kovarik Z , Zunec S , Garcia E , Zhang LM , Amitai G , Green C , Radic B , Duggan BM , Ajami D , Rebek J , Taylor P
Ref : Biochemical Journal , 450 :231 , 2013
PubMedID: 23216060

Title : Peripheral site and acyl pocket define selective inhibition of mouse butyrylcholinesterase by two biscarbamates - Bosak_2013_Arch.Biochem.Biophys_529_140
Author(s) : Bosak A , Smilovic IG , Stimac A , Vinkovic V , Sinko G , Kovarik Z
Ref : Archives of Biochemistry & Biophysics , 529 :140 , 2013
PubMedID: 23219600

Title : The cholinergic and non-cholinergic effects of organophosphates and oximes in cultured human myoblasts - Katalinic_2013_Chem.Biol.Interact_203_144
Author(s) : Katalinic M , Mis K , Pirkmajer S , Grubic Z , Kovarik Z , Mars T
Ref : Chemico-Biological Interactions , 203 :144 , 2013
PubMedID: 23047024

Title : Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates - Radic_2013_Chem.Biol.Interact_203_67
Author(s) : Radic Z , Sit RK , Garcia E , Zhang LM , Zunec S , Kovarik Z , Amitai G , Fokin VV , Sharpless KB , Taylor P
Ref : Chemico-Biological Interactions , 203 :67 , 2013
PubMedID: 22975155

Title : Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases - Radic_2012_J.Biol.Chem_287_11798
Author(s) : Radic Z , Sit RK , Kovarik Z , Zunec S , Garcia E , Zhang L , Amitai G , Green C , Radic B , Fokin VV , Sharpless KB , Taylor P
Ref : Journal of Biological Chemistry , 287 :11798 , 2012
PubMedID: 22343626

Title : Reactivation of Tabun-inhibited Acetylcholinesterase Investigated by Two Oximes and Mutagenesis - Katalinic_2012_Croatica.Chem.Acta_85_209
Author(s) : Katalinic M , Kovarik Z
Ref : Croatica Chemica Acta , 85 :209\ , 2012
PubMedID:

Title : Metaproterenol, isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors - Bosak_2012_J.Med.Chem_55_6716
Author(s) : Bosak A , Gazic Smilovic I , Sinko G , Vinkovic V , Kovarik Z
Ref : Journal of Medicinal Chemistry , 55 :6716 , 2012
PubMedID: 22817559

Title : A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning - Lovric_2011_Acta.Biochim.Pol_58_193
Author(s) : Lovric J , Zunec S , Lucic Vrdoljak A , Radic B , Katalinic M , Kovarik Z , Zeljezic D , Kopjar N , Rast S , Mesic M
Ref : Acta Biochim Pol , 58 :193 , 2011
PubMedID: 21666889

Title : Mechanism of stereoselective interaction between butyrylcholinesterase and ethopropazine enantiomers - Sinko_2011_Biochimie_93_1797
Author(s) : Sinko G , Kovarik Z , Reiner E , Simeon-Rudolf V , Stojan J
Ref : Biochimie , 93 :1797 , 2011
PubMedID: 21740955

Title : New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases - Sit_2011_J.Biol.Chem_286_19422
Author(s) : Sit RK , Radic Z , Gerardi V , Zhang L , Garcia E , Katalinic M , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P
Ref : Journal of Biological Chemistry , 286 :19422 , 2011
PubMedID: 21464125

Title : [Cholinesterases: structure, role, and inhibition] - Bosak_2011_Arh.Hig.Rada.Toksikol_62_175
Author(s) : Bosak A , Katalinic M , Kovarik Z
Ref : Arh Hig Rada Toksikol , 62 :175 , 2011
PubMedID: 21705306

Title : Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging - Cochran_2011_J.Biol.Chem_286_29718
Author(s) : Cochran R , Kalisiak J , Kucukkilinc TT , Radic Z , Garcia E , Zhang L , Ho KY , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P
Ref : Journal of Biological Chemistry , 286 :29718 , 2011
PubMedID: 21730071

Title : Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase - Kovarik_2010_Chem.Biol.Interact_187_167
Author(s) : Kovarik Z , Katalinic M , Sinko G , Binder J , Holas O , Jung YS , Musilova L , Jun D , Kuca K
Ref : Chemico-Biological Interactions , 187 :167 , 2010
PubMedID: 20206154

Title : Synthesis and evaluation of novel analogues of vitamin B6 as reactivators of tabun and paraoxon inhibited acetylcholinesterase - Gaso-Sokac_2010_Chem.Biol.Interact_187_234
Author(s) : Gaso-Sokac D , Katalinic M , Kovarik Z , Busic V , Kovac S
Ref : Chemico-Biological Interactions , 187 :234 , 2010
PubMedID: 20144593

Title : Interactions of pyridinium oximes with acetylcholinesterase - Sinko_2010_Chem.Biol.Interact_187_172
Author(s) : Sinko G , Brglez J , Kovarik Z
Ref : Chemico-Biological Interactions , 187 :172 , 2010
PubMedID: 20417629

Title : Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase - Katalinic_2010_Eur.J.Med.Chem_45_186
Author(s) : Katalinic M , Rusak G , Domacinovic Barovic J , Sinko G , Jelic D , Antolovic R , Kovarik Z
Ref : Eur Journal of Medicinal Chemistry , 45 :186 , 2010
PubMedID: 19879672

Title : In vivo experimental approach to treatment against tabun poisoning - Berend_2010_J.Enzyme.Inhib.Med.Chem_25_531
Author(s) : Zunec S , Katalinic M , Vrdoljak AL , Kovarik Z , Kuca K , Radic B
Ref : J Enzyme Inhib Med Chem , 25 :531 , 2010
PubMedID: 20235800

Title : Evaluation of oxime k203 as antidote in tabun poisoning - Kovarik_2009_Arh.Hig.Rada.Toksikol_60_19
Author(s) : Kovarik Z , Vrdoljak AL , Zunec S , Katalinic M , Kuc K , Musilek K , Radic B
Ref : Arh Hig Rada Toksikol , 60 :19 , 2009
PubMedID: 19329372

Title : Preparative HPLC separation of bambuterol enantiomers and stereoselective inhibition of human cholinesterases - Gazic_2008_Anal.Bioanal.Chem_385_1513
Author(s) : Gazic I , Bosak A , Sinko G , Vinkovic V , Kovarik Z
Ref : Anal Bioanal Chem , 385 :1513 , 2008
PubMedID: 16865342

Title : Stereoselective inhibition of human, mouse, and horse cholinesterases by bambuterol enantiomers - Bosak_2008_Chem.Biol.Interact_175_192
Author(s) : Bosak A , Gazic I , Vinkovic V , Kovarik Z
Ref : Chemico-Biological Interactions , 175 :192 , 2008
PubMedID: 18582854

Title : Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning - Kovarik_2008_Chem.Biol.Interact_175_173
Author(s) : Kovarik Z , Calic M , Sinko G , Bosak A , Zunec S , Vrdoljak AL , Radic B
Ref : Chemico-Biological Interactions , 175 :173 , 2008
PubMedID: 18501341

Title : Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases - Calic_2008_Chem.Biol.Interact_175_305
Author(s) : Calic M , Bosak A , Kuca K , Kovarik Z
Ref : Chemico-Biological Interactions , 175 :305 , 2008
PubMedID: 18501885

Title : Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol - Bosak_2008_Arch.Biochem.Biophys_471_72
Author(s) : Bosak A , Gazic I , Vinkovic V , Kovarik Z
Ref : Archives of Biochemistry & Biophysics , 471 :72 , 2008
PubMedID: 18167304

Title : Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors - Taylor_2007_Arh.Hig.Rada.Toksikol_58_339
Author(s) : Taylor P , Reiner E , Kovarik Z , Radic Z
Ref : Arh Hig Rada Toksikol , 58 :339 , 2007
PubMedID: 17913689

Title : Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure - Taylor_2007_Toxicology_233_70
Author(s) : Taylor P , Kovarik Z , Reiner E , Radic Z
Ref : Toxicology , 233 :70 , 2007
PubMedID: 17196318

Title : Structure-activity approach in the reactivation of tabun-phosphorylated human acetylcholinesterase with bispyridinium para-aldoximes - Kovarik_2007_Arh.Hig.Rada.Toksikol_58_201
Author(s) : Kovarik Z , Calic M , Sinko G , Bosak A
Ref : Arh Hig Rada Toksikol , 58 :201 , 2007
PubMedID: 17562604

Title : Evaluation of monoquaternary pyridinium oximes potency to reactivate tabun-inhibited human acetylcholinesterase - Odzak_2007_Toxicology_233_85
Author(s) : Odzak R , Calic M , Hrenar T , Primozic I , Kovarik Z
Ref : Toxicology , 233 :85 , 2007
PubMedID: 16962227

Title : Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates - Kovarik_2007_Toxicology_233_79
Author(s) : Kovarik Z , Radic Z , Berman HA , Taylor P
Ref : Toxicology , 233 :79 , 2007
PubMedID: 17046138

Title : Limitation of the Ellman method: cholinesterase activity measurement in the presence of oximes - Sinko_2007_Anal.Biochem_370_223
Author(s) : Sinko G , Calic M , Bosak A , Kovarik Z
Ref : Analytical Biochemistry , 370 :223 , 2007
PubMedID: 17716616

Title : In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity - Calic_2006_Toxicology_219_85
Author(s) : Calic M , Vrdoljak AL , Radic B , Jelic D , Jun D , Kuca K , Kovarik Z
Ref : Toxicology , 219 :85 , 2006
PubMedID: 16332406

Title : para- and ortho-Pyridinium aldoximes in reaction with acetylthiocholine - Sinko_2006_FEBS.Lett_580_3167
Author(s) : Sinko G , Calic M , Kovarik Z
Ref : FEBS Letters , 580 :3167 , 2006
PubMedID: 16684539

Title : Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP - Kovarik_2006_Biochem.Biophys.Res.Commun_342_973
Author(s) : Kovarik Z , Ciban N , Radic Z , Simeon-Rudolf V , Taylor P
Ref : Biochemical & Biophysical Research Communications , 342 :973 , 2006
PubMedID: 16598855

Title : Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning - Lucic_2006_Toxicology_228_41
Author(s) : Lucic Vrdoljak A , Calic M , Radic B , Zunec S , Jun D , Kuca K , Kovarik Z
Ref : Toxicology , 228 :41 , 2006
PubMedID: 16982122

Title : A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family - De Jaco_2006_J.Biol.Chem_281_9667
Author(s) : De Jaco A , Comoletti D , Kovarik Z , Gaietta G , Radic Z , Lockridge O , Ellisman MH , Taylor P
Ref : Journal of Biological Chemistry , 281 :9667 , 2006
PubMedID: 16434405

Title : Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice - Kovarik_2006_J.Mol.Neurosci_30_113
Author(s) : Kovarik Z , Calic M , Vrdoljak AL , Radic B
Ref : Journal of Molecular Neuroscience , 30 :113 , 2006
PubMedID: 17192653

Title : Structure-inhibition relationships in the interaction of butyrylcholinesterase with bambuterol, haloxon and their leaving groups -
Author(s) : Sinko G , Bosak A , Kovarik Z , Simeon-Rudolf V
Ref : Chemico-Biological Interactions , 157-158 :421 , 2005
PubMedID: 16429568

Title : A single mutation near the C-terminus in alpha\/beta hydrolase fold protein family causes a defect in protein processing - De Jaco_2005_Chem.Biol.Interact_157-158_371
Author(s) : De Jaco A , Kovarik Z , Comoletti D , Jennings LL , Gaietta G , Ellisman MH , Taylor P
Ref : Chemico-Biological Interactions , 157-158 :371 , 2005
PubMedID: 16429495

Title : Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates -
Author(s) : Kovarik Z , Radic Z , Simeon-Rudolf V , Reiner E , Taylor P
Ref : Chemico-Biological Interactions , 157-158 :388 , 2005
PubMedID: 16429526

Title : Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates - Kovarik_2004_Biochemistry_43_3222
Author(s) : Kovarik Z , Radic Z , Berman HA , Simeon-Rudolf V , Reiner E , Taylor P
Ref : Biochemistry , 43 :3222 , 2004
PubMedID: 15023072

Title : Interaction of human butyrylcholinesterase variants with bambuterol and terbutaline - Kovarik_2004_J.Enzyme.Inhib.Med.Chem_19_113
Author(s) : Kovarik Z , Simeon-Rudolf V
Ref : J Enzyme Inhib Med Chem , 19 :113 , 2004
PubMedID: 15449725

Title : Poster (89) Phosphorylation of mouse cholinesterases and mutants by ddvp and reactivation of conjugates by Hi-6 and 2-PAM -
Author(s) : Kovarik Z , Wong L , Radic Z , Taylor P
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :367 , 2004
PubMedID:

Title : Phosphonylation of acetylcholinesterase and the propensity for reactivation analysed by chirality and mutagenesis. -
Author(s) : Kovarik Z , Radic Z , Berman HA , Taylor P
Ref : Cholinergic Mechanisms, CRC Press :611 , 2004
PubMedID:

Title : Phosphorylation of mouse cholinesterases and mutants by DDVP and reactivation of conjugates by HI-6 and 2-PAM -
Author(s) : Kovarik Z , Wong L , Radic Z , Taylor P
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :219 , 2004
PubMedID:

Title : Acetylcholinesterase active centre and gorge conformations analyzed by combinatorial mutations and enantiomeric phosphonates - Kovarik_2003_Biochem.J_373_33
Author(s) : Kovarik Z , Radic Z , Berman HA , Simeon-Rudolf V , Reiner E , Taylor P
Ref : Biochemical Journal , 31 :33 , 2003
PubMedID: 12665427

Title : An improvement in segregation of human butyrylcholinesterase phenotypes having the fluoride-resistant variants - Kovarik_2003_Arh.Hig.Rada.Toksikol_54_239
Author(s) : Kovarik Z , Simeon-Rudolf V
Ref : Arh Hig Rada Toksikol , 54 :239 , 2003
PubMedID: 14994645

Title : Exploring the Active Sites of Cholinesterases by Inhibition with Bambuterol and Haloxon - Kovarik_2003_Croatica.Chem.Acta_76_63
Author(s) : Kovarik Z , Bosac A , Sinko G , Latas T
Ref : Croatica Chemica Acta , 76 :63 , 2003
PubMedID:
Gene_locus related to this paper: horse-BCHE

Title : Reversible inhibition of acetylcholinesterase and butyrylcholinesterase by 4,4'-bipyridine and by a coumarin derivative - Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119
Author(s) : Simeon-Rudolf V , Kovarik Z , Radic Z , Reiner E
Ref : Chemico-Biological Interactions , 119-120 :119 , 1999
PubMedID: 10421445

Title : Amino acid residues involved in the interaction of acetylcholinesterase and butyrylcholinesterase with the carbamates Ro 02-0683 and bambuterol, and with terbutaline - Kovarik_1999_Biochim.Biophys.Acta_1433_261
Author(s) : Kovarik Z , Radic Z , Grgas B , Skrinjaric-Spoljar M , Reiner E , Simeon-Rudolf V
Ref : Biochimica & Biophysica Acta , 1433 :261 , 1999
PubMedID: 10446376

Title : An explanation for the different inhibitory characteristics of human serum butyrylcholinesterase phenotypes deriving from inhibition of atypical heterozygotes - Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_159
Author(s) : Simeon-Rudolf V , Kovarik Z , Skrinjaric-Spoljar M , Evans RT
Ref : Chemico-Biological Interactions , 119-120 :159 , 1999
PubMedID: 10421449

Title : Inhibition of Acetylcholinesterase (ACHE\; E.C. 3.1.1.7) and Butyrylcholinesterase (BCHE\; E.C. 3.1.1.8) by Terbutaline -
Author(s) : Kovarik Z , Radic Z , Skrinjaric-Spoljar M , Reiner E , Simeon-Rudolf V
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :243 , 1998
PubMedID: