Title : Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway - Hu_2013_CNS.Neurosci.Ther_19_764 |
Author(s) : Hu SQ , Cui W , Xu DP , Mak SH , Tang J , Choi CL , Pang YP , Han YF |
Ref : CNS Neurosci Ther , 19 :764 , 2013 |
Abstract :
BACKGROUND: Neuronal loss via apoptosis in CNS is the fundamental mechanism underlying various neurodegenerative diseases. Compounds with antiapoptotic property might have therapeutic effects for these diseases. In this study, bis(propyl)-cognitin (B3C), a novel dimer that possesses anti-AChE and anti-N-methyl-d-aspartate receptor activities, was investigated for its neuroprotective effect on K(+) deprivation-induced apoptosis in cerebellar granule neurons (CGNs). |
PubMedSearch : Hu_2013_CNS.Neurosci.Ther_19_764 |
PubMedID: 23826635 |
Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF (2013)
Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway
CNS Neurosci Ther
19 :764
Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF (2013)
CNS Neurosci Ther
19 :764