| Title : Non Susceptibility of Neonatal and Adult Rats against the Middle East Respiratory Syndrome Coronavirus - Iwata-Yoshikawa_2016_Jpn.J.Infect.Dis_69_510 |
| Author(s) : Iwata-Yoshikawa N , Fukushi S , Fukuma A , Suzuki T , Takeda M , Tashiro M , Hasegawa H , Nagata N |
| Ref : Jpn J Infect Dis , 69 :510 , 2016 |
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Abstract :
The present study examined the susceptibility of rats to the Middle East respiratory syndrome coronavirus (MERS-CoV) and determined whether this animal is a suitable model for MERS-CoV infection. Immunohistochemical analysis identified dipeptidyl peptidase 4 (DPP4), a known receptor for MERS-CoV on type I pneumocytes from infected rats. Whereas adult rats developed antibodies against MERS-CoV spike protein after intranasal inoculation, there was no evidence of viral replication in the lungs of adult, young, or neonatal rats after intranasal inoculation with MERS-CoV. In addition, human DPP4-expressing rat kidney fibroblasts, but not rat DPP4-expressing cells, were susceptible to MERS-CoV. Taken together, these results suggest that the rat is not a useful animal model for studying MERS-CoV infection. |
| PubMedSearch : Iwata-Yoshikawa_2016_Jpn.J.Infect.Dis_69_510 |
| PubMedID: 27000459 |
Iwata-Yoshikawa N, Fukushi S, Fukuma A, Suzuki T, Takeda M, Tashiro M, Hasegawa H, Nagata N (2016)
Non Susceptibility of Neonatal and Adult Rats against the Middle East Respiratory Syndrome Coronavirus
Jpn J Infect Dis
69 :510
Iwata-Yoshikawa N, Fukushi S, Fukuma A, Suzuki T, Takeda M, Tashiro M, Hasegawa H, Nagata N (2016)
Jpn J Infect Dis
69 :510