| Title : Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver - Johansson_1995_Arch.Toxicol_70_61 |
| Author(s) : Johansson C , Stark A , Sandberg M , Ek B , Rask L , Meijer J |
| Ref : Archives of Toxicology , 70 :61 , 1995 |
|
Abstract :
The soluble epoxide hydrolase mRNA level in liver was increased eight-fold upon administration of the hypolipidemic drug and peroxisome proliferator clofibrate for 7 days to mice. The soluble epoxide hydrolase mRNA was back at control levels within 1-2 days after clofibrate withdrawal. The highest expression was in liver, intestine and kidney. Lower levels were found in heart and muscle and very low levels were found in testes, lung, brain and spleen. The mRNA levels were increased in liver, kidney and heart by clofibrate. |
| PubMedSearch : Johansson_1995_Arch.Toxicol_70_61 |
| PubMedID: 8750907 |
| Gene_locus related to this paper: mouse-hyes |
| Substrate | Clofibrate |
| Gene_locus | mouse-hyes |
Johansson C, Stark A, Sandberg M, Ek B, Rask L, Meijer J (1995)
Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver
Archives of Toxicology
70 :61
Johansson C, Stark A, Sandberg M, Ek B, Rask L, Meijer J (1995)
Archives of Toxicology
70 :61