mouse-hyes

Mus musculus soluble epoxide hydrolase 2, cytoplasmic (Ephx2), mRNA

Comment

C-terminal of Ephx2 has 20\% identity with haloalkane dehalogenase and has the a\/b hydrolase fold. The N-terminal part is homologous to bacterial haloacid dehalogenase. Q9DCW0 (now obsolete )and P3491 differ by one aa PfamA Abhydrolase_1 284 539

Relationship

Family : Epoxide_hydrolase

Block : X

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Database

Sequence

Peptide

HGYVTVKPGI RLHFVEMGSG PALCLCHGFP ESWFSWRYQI PALAQAGFRV LAIDMKGYGD SSSPPEIEEY AMELLCKEMV TFLDKLGIPQ AVFIGHDWAG VMVWNMALFY PERVRAVASL NTPFMPPDPD VSPMKVIRSI PVFNYQLYFQ EPGVAEAELE KNMSRTFKSF FRASDETGFI AVHKATEIGG ILVNTPEDPN LSKITTEEEI EFYIQQFKKT GFRGPLNWYR NTERNWKWSC KGLGRKILVP ALMVTAEKDI VLRPEMSKNM EKWIPFLKRG HIEDCGHWTQ IEKPTEVNQI LIKWLQTEVQ NPSVTSKI

References (15)

Title : The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer - Kesavan_2021_Int.J.Mol.Sci_22_
Author(s) : Kesavan R , Fromel T , Zukunft S , Brune B , Weigert A , Wittig I , Popp R , Fleming I
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 34281173
Gene_locus related to this paper: mouse-hyes

Title : Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation - Wagner_2021_Front.Pharmacol_12_778470
Author(s) : Wagner KM , Yang J , Morisseau C , Hammock BD
Ref : Front Pharmacol , 12 :778470 , 2021
PubMedID: 34975481
Gene_locus related to this paper: mouse-hyes

Title : Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation - Samokhvalov_2019_Front.Pharmacol_9_1572
Author(s) : Samokhvalov V , Jamieson KL , Darwesh AM , Keshavarz-Bahaghighat H , Lee TYT , Edin M , Lih F , Zeldin DC , Seubert JM
Ref : Front Pharmacol , 9 :1572 , 2019
PubMedID: 30692927
Gene_locus related to this paper: mouse-hyes

Title : Hypoxia-Induced Neuroinflammation and Learning-Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine - Lee_2018_Mol.Neurobiol_55_8738
Author(s) : Lee Y , Lee S , Park JW , Hwang JS , Kim SM , Lyoo IK , Lee CJ , Han IO
Ref : Molecular Neurobiology , 55 :8738 , 2018
PubMedID: 29589284
Gene_locus related to this paper: mouse-hyes

Title : Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia - Edin_2018_J.Biol.Chem_293_3281
Author(s) : Edin ML , Hamedani BG , Gruzdev A , Graves JP , Lih FB , Arbes SJ, 3rd , Singh R , Orjuela Leon AC , Bradbury JA , DeGraff LM , Hoopes SL , Arand M , Zeldin DC
Ref : Journal of Biological Chemistry , 293 :3281 , 2018
PubMedID: 29298899
Gene_locus related to this paper: mouse-EPHX1 , mouse-hyes

Title : Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress - Ren_2016_Proc.Natl.Acad.Sci.U.S.A_113_E1944
Author(s) : Ren Q , Ma M , Ishima T , Morisseau C , Yang J , Wagner KM , Zhang JC , Yang C , Yao W , Dong C , Han M , Hammock BD , Hashimoto K
Ref : Proc Natl Acad Sci U S A , 113 :E1944 , 2016
PubMedID: 26976569
Gene_locus related to this paper: mouse-hyes

Title : A novel ovary-specific and ovulation-associated variant of epoxide hydrolase 2 - Shkolnik_2007_FEBS.Lett_581_4891
Author(s) : Shkolnik K , Ben-Dor S , Galiani D , Hourvitz A , Dekel N
Ref : FEBS Letters , 581 :4891 , 2007
PubMedID: 17900570
Gene_locus related to this paper: mouse-hyes

Title : Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs - Okazaki_2002_Nature_420_563
Author(s) : Okazaki Y , Furuno M , Kasukawa T , Adachi J , Bono H , Kondo S , Nikaido I , Osato N , Saito R , Suzuki H , Yamanaka I , Kiyosawa H , Yagi K , Tomaru Y , Hasegawa Y , Nogami A , Schonbach C , Gojobori T , Baldarelli R , Hill DP , Bult C , Hume DA , Quackenbush J , Schriml LM , Kanapin A , Matsuda H , Batalov S , Beisel KW , Blake JA , Bradt D , Brusic V , Chothia C , Corbani LE , Cousins S , Dalla E , Dragani TA , Fletcher CF , Forrest A , Frazer KS , Gaasterland T , Gariboldi M , Gissi C , Godzik A , Gough J , Grimmond S , Gustincich S , Hirokawa N , Jackson IJ , Jarvis ED , Kanai A , Kawaji H , Kawasawa Y , Kedzierski RM , King BL , Konagaya A , Kurochkin IV , Lee Y , Lenhard B , Lyons PA , Maglott DR , Maltais L , Marchionni L , McKenzie L , Miki H , Nagashima T , Numata K , Okido T , Pavan WJ , Pertea G , Pesole G , Petrovsky N , Pillai R , Pontius JU , Qi D , Ramachandran S , Ravasi T , Reed JC , Reed DJ , Reid J , Ring BZ , Ringwald M , Sandelin A , Schneider C , Semple CA , Setou M , Shimada K , Sultana R , Takenaka Y , Taylor MS , Teasdale RD , Tomita M , Verardo R , Wagner L , Wahlestedt C , Wang Y , Watanabe Y , Wells C , Wilming LG , Wynshaw-Boris A , Yanagisawa M , Yang I , Yang L , Yuan Z , Zavolan M , Zhu Y , Zimmer A , Carninci P , Hayatsu N , Hirozane-Kishikawa T , Konno H , Nakamura M , Sakazume N , Sato K , Shiraki T , Waki K , Kawai J , Aizawa K , Arakawa T , Fukuda S , Hara A , Hashizume W , Imotani K , Ishii Y , Itoh M , Kagawa I , Miyazaki A , Sakai K , Sasaki D , Shibata K , Shinagawa A , Yasunishi A , Yoshino M , Waterston R , Lander ES , Rogers J , Birney E , Hayashizaki Y
Ref : Nature , 420 :563 , 2002
PubMedID: 12466851
Gene_locus related to this paper: mouse-1lipg , mouse-1llip , mouse-1plrp , mouse-3neur , mouse-ABH15 , mouse-abhd4 , mouse-abhd5 , mouse-Abhd8 , mouse-Abhd11 , mouse-abhda , mouse-acot4 , mouse-adcl4 , mouse-AI607300 , mouse-BAAT , mouse-bphl , mouse-C87498 , mouse-Ldah , mouse-Ces1d , mouse-Ces2e , mouse-CMBL , mouse-DGLB , mouse-dpp9 , mouse-ES10 , mouse-F135A , mouse-FASN , mouse-hslip , mouse-hyes , mouse-Kansl3 , mouse-LIPH , mouse-LIPK , mouse-lipli , mouse-LIPM , mouse-lypla1 , mouse-lypla2 , mouse-MEST , mouse-MGLL , mouse-ndr4 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-ppce , mouse-Ppgb , mouse-PPME1 , mouse-q3uuq7 , mouse-Q8BLF1 , mouse-ACOT6 , mouse-Q8C1A9 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-Q8BGG9 , mouse-Q8C167 , mouse-rbbp9 , mouse-SERHL , mouse-tssp

Title : Functional annotation of a full-length mouse cDNA collection - Kawai_2001_Nature_409_685
Author(s) : Kawai J , Shinagawa A , Shibata K , Yoshino M , Itoh M , Ishii Y , Arakawa T , Hara A , Fukunishi Y , Konno H , Adachi J , Fukuda S , Aizawa K , Izawa M , Nishi K , Kiyosawa H , Kondo S , Yamanaka I , Saito T , Okazaki Y , Gojobori T , Bono H , Kasukawa T , Saito R , Kadota K , Matsuda H , Ashburner M , Batalov S , Casavant T , Fleischmann W , Gaasterland T , Gissi C , King B , Kochiwa H , Kuehl P , Lewis S , Matsuo Y , Nikaido I , Pesole G , Quackenbush J , Schriml LM , Staubli F , Suzuki R , Tomita M , Wagner L , Washio T , Sakai K , Okido T , Furuno M , Aono H , Baldarelli R , Barsh G , Blake J , Boffelli D , Bojunga N , Carninci P , de Bonaldo MF , Brownstein MJ , Bult C , Fletcher C , Fujita M , Gariboldi M , Gustincich S , Hill D , Hofmann M , Hume DA , Kamiya M , Lee NH , Lyons P , Marchionni L , Mashima J , Mazzarelli J , Mombaerts P , Nordone P , Ring B , Ringwald M , Rodriguez I , Sakamoto N , Sasaki H , Sato K , Schonbach C , Seya T , Shibata Y , Storch KF , Suzuki H , Toyo-oka K , Wang KH , Weitz C , Whittaker C , Wilming L , Wynshaw-Boris A , Yoshida K , Hasegawa Y , Kawaji H , Kohtsuki S , Hayashizaki Y
Ref : Nature , 409 :685 , 2001
PubMedID: 11217851
Gene_locus related to this paper: mouse-1lipg , mouse-1plip , mouse-1plrp , mouse-ABH15 , mouse-abhd5 , mouse-ABHD6 , mouse-Abhd8 , mouse-aryla , mouse-bphl , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-EPHX1 , mouse-ES10 , mouse-hslip , mouse-hyes , mouse-ABHD2 , mouse-lcat , mouse-lipli , mouse-LIPN , mouse-lypla1 , mouse-lypla2 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-Ppgb , mouse-PPME1 , mouse-ppt , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-RISC , mouse-SERHL , mouse-SPG21 , mouse-Tex30

Title : Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes - Carninci_2000_Genome.Res_10_1617
Author(s) : Carninci P , Shibata Y , Hayatsu N , Sugahara Y , Shibata K , Itoh M , Konno H , Okazaki Y , Muramatsu M , Hayashizaki Y
Ref : Genome Res , 10 :1617 , 2000
PubMedID: 11042159
Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-hyes , mouse-lipli , mouse-LIPN , mouse-pafa , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC

Title : Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase - Argiriadi_1999_Proc.Natl.Acad.Sci.U.S.A_96_10637
Author(s) : Argiriadi MA , Morisseau C , Hammock BD , Christianson DW
Ref : Proceedings of the National Academy of Sciences of the United States of America , 96 :10637 , 1999
PubMedID: 10485878
Gene_locus related to this paper: mouse-hyes

Title : Potent urea and carbamate inhibitors of soluble epoxide hydrolases - Morisseau_1999_Proc.Natl.Acad.Sci.U.S.A_96_8849
Author(s) : Morisseau C , Goodrow MH , Dowdy D , Zheng J , Greene JF , Sanborn JR , Hammock BD
Ref : Proc Natl Acad Sci U S A , 96 :8849 , 1999
PubMedID: 10430859
Gene_locus related to this paper: mouse-hyes

Title : Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver - Johansson_1995_Arch.Toxicol_70_61
Author(s) : Johansson C , Stark A , Sandberg M , Ek B , Rask L , Meijer J
Ref : Archives of Toxicology , 70 :61 , 1995
PubMedID: 8750907
Gene_locus related to this paper: mouse-hyes

Title : Gene evolution of epoxide hydrolases and recommended nomenclature - Beetham_1995_DNA.Cell.Biol_14_61
Author(s) : Beetham JK , Grant D , Arand M , Garbarino J , Kiyosue T , Pinot F , Oesch F , Belknap WR , Shinozaki K , Hammock BD
Ref : DNA & Cell Biology , 14 :61 , 1995
PubMedID: 7832993
Gene_locus related to this paper: mouse-hyes

Title : Molecular cloning and expression of murine liver soluble epoxide hydrolase - Grant_1993_J.Biol.Chem_268_17628
Author(s) : Grant DF , Storms DH , Hammock BD
Ref : Journal of Biological Chemistry , 268 :17628 , 1993
PubMedID: 8349642
Gene_locus related to this paper: mouse-hyes