Clofibrate
General
Type : Pro-Drug || Drug || Not A\/B H target || Propionate
Chemical_Nomenclature : ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
Canonical SMILES : CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl
InChI : InChI=1S\/C12H15ClO3\/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10\/h5-8H,4H2,1-3H3
InChIKey : KNHUKKLJHYUCFP-UHFFFAOYSA-N
Other name(s) : Ethyl clofibrate, Atromid-S, CHEBI:3750, CHEMBL565, SCHEMBL2356, DB00636
Target
Families : Carb_B_Chordata
References (9)
| Title : Clofibrate, a PPAR-alpha agonist, abrogates sodium fluoride-induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP\/Iba-1\/anti-calbindin signaling pathways - Oyagbemi_2020_Environ.Toxicol_35_242 |
| Author(s) : Oyagbemi AA , Adebiyi OE , Adigun KO , Ogunpolu BS , Falayi OO , Hassan FO , Folarin OR , Adebayo AK , Adejumobi OA , Asenuga ER , Ola-Davies OE , Omobowale TO , Olopade JO , Saba AB , Adedapo AA , Nkadimeng SM , McGaw LJ , Oguntibeju OO , Yakubu MA |
| Ref : Environ Toxicol , 35 :242 , 2020 |
| PubMedID: 31710167 |
| Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
| Ref : Eur J Pharm Sci , 78 :47 , 2015 |
| PubMedID: 26164127 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki - Nunes_2004_Chemosphere_57_1581 |
| Author(s) : Nunes B , Carvalho F , Guilhermino L |
| Ref : Chemosphere , 57 :1581 , 2004 |
| PubMedID: 15519403 |
| Title : Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster - Taniai_2003_Eur.J.Biochem_270_4696 |
| Author(s) : Taniai K , Inceoglu AB , Yukuhiro K , Hammock BD |
| Ref : European Journal of Biochemistry , 270 :4696 , 2003 |
| PubMedID: 14622257 |
| Gene_locus related to this paper: drome-CG15102 |
| Title : Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones - Parker_1996_Biochem.Pharmacol_51_677 |
| Author(s) : Parker AG , Pinot F , Grant DF , Spearow J , Hammock BD |
| Ref : Biochemical Pharmacology , 51 :677 , 1996 |
| PubMedID: 8615905 |
| Title : Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver - Johansson_1995_Arch.Toxicol_70_61 |
| Author(s) : Johansson C , Stark A , Sandberg M , Ek B , Rask L , Meijer J |
| Ref : Archives of Toxicology , 70 :61 , 1995 |
| PubMedID: 8750907 |
| Gene_locus related to this paper: mouse-hyes |
| Title : Fat intake and clofibrate administration have interrelated effects on liver cholesterol concentration and serum butyryl cholinesterase activity in rats - Van Lith_1992_J.Nutr_122_2283 |
| Author(s) : Van Lith HA , Haller M , Van Tintelen G , Lemmens AG , Van Zutphen LF , Beynen AC |
| Ref : J Nutr , 122 :2283 , 1992 |
| PubMedID: 1432266 |
| Title : Hydrolysis of ester- and amide-type drugs by the purified isoenzymes of nonspecific carboxylesterase from rat liver - Mentlein_1984_Biochem.Pharmacol_33_1243 |
| Author(s) : Mentlein R , Heymann E |
| Ref : Biochemical Pharmacology , 33 :1243 , 1984 |
| PubMedID: 6712734 |
| Title : Effect of clofibrate on postheparin plasma triglyceride lipase activities in patients with hypertriglyceridemia - Nikkila_1977_Metabolism_26_179 |
| Author(s) : Nikkila EA , Huttunen JK , Ehnholm C |
| Ref : Metabolism , 26 :179 , 1977 |
| PubMedID: 834151 |