| Title : Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors - Kapanda_2009_J.Med.Chem_52_7310 |
| Author(s) : Kapanda CN , Muccioli GG , Labar G , Poupaert JH , Lambert DM |
| Ref : Journal of Medicinal Chemistry , 52 :7310 , 2009 |
|
Abstract :
Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme. |
| PubMedSearch : Kapanda_2009_J.Med.Chem_52_7310 |
| PubMedID: 19883085 |
| Inhibitor | ATFMK |
Kapanda CN, Muccioli GG, Labar G, Poupaert JH, Lambert DM (2009)
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors
Journal of Medicinal Chemistry
52 :7310
Kapanda CN, Muccioli GG, Labar G, Poupaert JH, Lambert DM (2009)
Journal of Medicinal Chemistry
52 :7310