ATFMK
not specific Phospholipase A 2 inhibitor FAAH inhibitor. MGLL IC50 6.31 microM
General
Chemical_Nomenclature : (6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
Canonical SMILES : CCCCC\/C=CC\/C=CC\/C=CC\/C=CCCCC(=O)C(F)(F)F || CCCCCC=CCC=CCC=CCC=CCCCC(=O)C(F)(F)F || CCCCC\/C=C\/C\/C=C\/C\/C=C\/C\/C=C\/CCCC(=O)C(F)(F)F
InChI : InChI=1S\/C21H31F3O\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24\/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3\/b7-6-,10-9-,13-12-,16-15- || InChI=1S\/C21H31F3O\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24\/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3 || InChI=1S\/C21H31F3O\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24\/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3\/b7-6+,10-9+,13-12+,16-15+
InChIKey : PLWROONZUDKYKG-DOFZRALJSA-N || PLWROONZUDKYKG-UHFFFAOYSA-N || PLWROONZUDKYKG-CGRWFSSPSA-N
Other name(s) : Arachidonyltrifluoromethane || Arachidonic acid trifluoromethyl ketone || 6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (6Z,9Z,12Z,15Z)- || 00XIW1CR0F || DTXSID901017144 || CHEBI:2341 || CHEMBL281211 || SCHEMBL9880640 || SCHEMBL30426991 || CHEBI:94989 || 1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one || (6E,9E,12E,15E)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
MW : 356.5
Formula : C21H31F3O
CAS_number : 149301-79-1
PubChem : 5280436, 2224, 5353415
UniChem : PLWROONZUDKYKG-DOFZRALJSA-N, PLWROONZUDKYKG-UHFFFAOYSA-N, PLWROONZUDKYKG-CGRWFSSPSA-N
Target
Families : ATFMK ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (9)
| Title : Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors - Kapanda_2009_J.Med.Chem_52_7310 |
| Author(s) : Kapanda CN , Muccioli GG , Labar G , Poupaert JH , Lambert DM |
| Ref : Journal of Medicinal Chemistry , 52 :7310 , 2009 |
| Abstract : |
| PubMedSearch : Kapanda_2009_J.Med.Chem_52_7310 |
| PubMedID: 19883085 |
| Title : Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors - Kapanda_2009_J.Med.Chem_52_7310 |
| Author(s) : Kapanda CN , Muccioli GG , Labar G , Poupaert JH , Lambert DM |
| Ref : Journal of Medicinal Chemistry , 52 :7310 , 2009 |
| Abstract : |
| PubMedSearch : Kapanda_2009_J.Med.Chem_52_7310 |
| PubMedID: 19883085 |
| Title : Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors - Matuszak_2009_J.Med.Chem_52_7410 |
| Author(s) : Matuszak N , Muccioli GG , Labar G , Lambert DM |
| Ref : Journal of Medicinal Chemistry , 52 :7410 , 2009 |
| Abstract : |
| PubMedSearch : Matuszak_2009_J.Med.Chem_52_7410 |
| PubMedID: 19583260 |
| Gene_locus related to this paper: human-MGLL |
| Title : Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors - Matuszak_2009_J.Med.Chem_52_7410 |
| Author(s) : Matuszak N , Muccioli GG , Labar G , Lambert DM |
| Ref : Journal of Medicinal Chemistry , 52 :7410 , 2009 |
| Abstract : |
| PubMedSearch : Matuszak_2009_J.Med.Chem_52_7410 |
| PubMedID: 19583260 |
| Gene_locus related to this paper: human-MGLL |
| Title : Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors - Matuszak_2009_J.Med.Chem_52_7410 |
| Author(s) : Matuszak N , Muccioli GG , Labar G , Lambert DM |
| Ref : Journal of Medicinal Chemistry , 52 :7410 , 2009 |
| Abstract : |
| PubMedSearch : Matuszak_2009_J.Med.Chem_52_7410 |
| PubMedID: 19583260 |
| Gene_locus related to this paper: human-MGLL |
| Title : Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors - Kapanda_2009_J.Med.Chem_52_7310 |
| Author(s) : Kapanda CN , Muccioli GG , Labar G , Poupaert JH , Lambert DM |
| Ref : Journal of Medicinal Chemistry , 52 :7310 , 2009 |
| Abstract : |
| PubMedSearch : Kapanda_2009_J.Med.Chem_52_7310 |
| PubMedID: 19883085 |
| Title : A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation - Dinh_2002_Chem.Phys.Lipids_121_149 |
| Author(s) : Dinh TP , Freund TF , Piomelli D |
| Ref : Chemistry & Physic of Lipids , 121 :149 , 2002 |
| Abstract : |
| PubMedSearch : Dinh_2002_Chem.Phys.Lipids_121_149 |
| PubMedID: 12505697 |
| Gene_locus related to this paper: human-MGLL |
| Title : A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation - Dinh_2002_Chem.Phys.Lipids_121_149 |
| Author(s) : Dinh TP , Freund TF , Piomelli D |
| Ref : Chemistry & Physic of Lipids , 121 :149 , 2002 |
| Abstract : |
| PubMedSearch : Dinh_2002_Chem.Phys.Lipids_121_149 |
| PubMedID: 12505697 |
| Gene_locus related to this paper: human-MGLL |
| Title : A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation - Dinh_2002_Chem.Phys.Lipids_121_149 |
| Author(s) : Dinh TP , Freund TF , Piomelli D |
| Ref : Chemistry & Physic of Lipids , 121 :149 , 2002 |
| Abstract : |
| PubMedSearch : Dinh_2002_Chem.Phys.Lipids_121_149 |
| PubMedID: 12505697 |
| Gene_locus related to this paper: human-MGLL |