Kassa_2007_Mil.Med.Sci.Lett_76_27

The reactivating efficacy of newly synthesized oximes (K074, K075) and the oximes introduced into the Czech Army for the first aid (obidoxime) and medical care (HI-6) was evaluated in male Wistar rats. The potency of oximes to reactivate tabun or soman-inhibited acetylcholinesterase was evaluated by the comparison of the activity of acetylcholinesterase in rat's blood and brain measured 30 minutes following tabun or soman poisoning. The obtained results demonstrate that newly synthesized oximes are more effective than currently used oximes in the reactivation of tabun-inhibited brain acetylcholinesterase but less effective than the oxime HI-6 against soman.