Toxogonin

General

Type : Oxime, Bisoxime, Bispyridinium

Chemical_Nomenclature : oxo-[[1-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxymethyl]pyridin-4-ylidene]methyl]azanium\;dichloride

Canonical SMILES : C1=CN(C=CC1=C[NH+]=O)COCN2C=CC(=C[NH+]=O)C=C2.[Cl-].[Cl-]

InChI : InChI=1S\/C14H14N4O3.2ClH\/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20\;\;\/h1-10H,11-12H2\;2*1H

InChIKey : ZIFJVJZWVSPZLE-UHFFFAOYSA-N

Other name(s) : Obidoxime Chloride  ||  Lo-6  ||  Obidoxime  ||  Obidoxim  ||  Toxogonine  ||  DMO4  ||  LuH6  ||  Lu6  ||  1,1'-[Oxysbis(methylene)bis[$-(hydroxyimino)methyl]pyridinium dichloride  ||  1,1'-oxydimethylene bis -[4-formyl pyridinium bromide]dioxime


MW : 359.20

Formula : C14H16Cl2N4O3

CAS_number : 114-90-9

PubChem : 5359290,    8251

UniChem : ZIFJVJZWVSPZLE-UHFFFAOYSA-N

Target

Structure : 2GYW

Families : No family

References (95)

Title : The reactivation kinetic analysis, molecular docking, and dynamics of oximes against three V-type nerve agents inhibited four human cholinesterases - Li_2024_Chem.Biol.Interact__111061
Author(s) : Li K , Liu Y , Li Q , Guo L , Xie J
Ref : Chemico-Biological Interactions , :111061 , 2024
Abstract :
PubMedSearch : Li_2024_Chem.Biol.Interact__111061
PubMedID: 38763347

Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC
Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019
Abstract :
PubMedSearch : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
PubMedID: 31074292

Title : The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime - Lorke_2019_Front.Neurosci_13_427
Author(s) : Lorke DE , Petroianu GA
Ref : Front Neurosci , 13 :427 , 2019
Abstract :
PubMedSearch : Lorke_2019_Front.Neurosci_13_427
PubMedID: 31191210

Title : Efficacy of atropine sulfate\/obidoxime chloride co-formulation against sarin exposure in guinea pigs - Joosen_2018_Chem.Biol.Interact_296_34
Author(s) : Joosen MJ , Klaassen SD , Verheij E , van Groningen T , Cornelissen AS , Skiadopoulos MH , Cochrane L , Shearer JD
Ref : Chemico-Biological Interactions , 296 :34 , 2018
Abstract :
PubMedSearch : Joosen_2018_Chem.Biol.Interact_296_34
PubMedID: 30217478

Title : Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6 - Wille_2017_Arch.Toxicol_91_1309
Author(s) : Wille T , von der Wellen J , Thiermann H , Worek F
Ref : Archives of Toxicology , 91 :1309 , 2017
Abstract :
PubMedSearch : Wille_2017_Arch.Toxicol_91_1309
PubMedID: 27358236

Title : Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning - Krishnan_2016_Neurotoxicol_53_64
Author(s) : Krishnan JK , Arun P , Appu AP , Vijayakumar N , Figueiredo TH , Braga MF , Baskota S , Olsen CH , Farkas N , Dagata J , Frey WH, 2nd , Moffett JR , Namboodiri AM
Ref : Neurotoxicology , 53 :64 , 2016
Abstract :
PubMedSearch : Krishnan_2016_Neurotoxicol_53_64
PubMedID: 26751814

Title : Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics - Worek_2016_Toxicology_350-352_25
Author(s) : Worek F , Koller M , Thiermann H , Wille T
Ref : Toxicology , 350-352 :25 , 2016
Abstract :
PubMedSearch : Worek_2016_Toxicology_350-352_25
PubMedID: 27153754

Title : Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report - Steinritz_2016_Toxicol.Lett_244_121
Author(s) : Steinritz D , Eyer F , Worek F , Thiermann H , John H
Ref : Toxicol Lett , 244 :121 , 2016
Abstract :
PubMedSearch : Steinritz_2016_Toxicol.Lett_244_121
PubMedID: 26200596

Title : A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice - Kassa_2015_Toxicol.Mech.Methods_25_229
Author(s) : Kassa J , Sepsova V , Matouskova L , Horova A , Musilek K
Ref : Toxicol Mech Methods , 25 :229 , 2015
Abstract :
PubMedSearch : Kassa_2015_Toxicol.Mech.Methods_25_229
PubMedID: 25894563

Title : Pd(II) complexes of acetylcholinesterase reactivator obidoxime - Nedzhib_2014_Interdiscip.Toxicol_7_139
Author(s) : Nedzhib A , Stoykova S , Atanasov V , Pantcheva I , Antonov L
Ref : Interdiscip Toxicol , 7 :139 , 2014
Abstract :
PubMedSearch : Nedzhib_2014_Interdiscip.Toxicol_7_139
PubMedID: 26109891

Title : A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques - Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790
Author(s) : Bajgar J , Hajek P , Karasova JZ , Kassa J , Paseka A , Slizova D , Krs O , Kuca K , Jun D , Fusek J , Capek L
Ref : J Enzyme Inhib Med Chem , 25 :790 , 2010
Abstract :
PubMedSearch : Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790
PubMedID: 21054236

Title : Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds - Thiermann_2010_Toxicol.Lett_197_236
Author(s) : Thiermann H , Eyer F , Felgenhauer N , Pfab R , Zilker T , Eyer P , Worek F
Ref : Toxicol Lett , 197 :236 , 2010
Abstract :
PubMedSearch : Thiermann_2010_Toxicol.Lett_197_236
PubMedID: 20542100

Title : Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration - Karasova_2010_Anal.Sci_26_63
Author(s) : Karasova JZ , Novotny L , Antos K , Zivna H , Kuca K
Ref : Anal Sci , 26 :63 , 2010
Abstract :
PubMedSearch : Karasova_2010_Anal.Sci_26_63
PubMedID: 20065589

Title : A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats - Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861
Author(s) : Kassa J , Karasova JZ , Tesarova S , Musilek K , Kuca K , Jung YS
Ref : Basic Clin Pharmacol Toxicol , 107 :861 , 2010
Abstract :
PubMedSearch : Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861
PubMedID: 22545968

Title : A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice - Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480
Author(s) : Kassa J , Karasova JZ , Caisberger F , Musilek K , Kuca K , Jung YS
Ref : J Enzyme Inhib Med Chem , 25 :480 , 2010
Abstract :
PubMedSearch : Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480
PubMedID: 20233085

Title : Characterization of the anticholinergic properties of obidoxime\; functional examinations of the rat atria and the urinary bladder - Soukup_2010_Toxicol.Mech.Methods_20_428
Author(s) : Soukup O , Tobin G , Kumar UK , Jun D , Fusek J , Kuca K
Ref : Toxicol Mech Methods , 20 :428 , 2010
Abstract :
PubMedSearch : Soukup_2010_Toxicol.Mech.Methods_20_428
PubMedID: 20602545

Title : A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice - Kassa_2010_Drug.Chem.Toxicol_33_227
Author(s) : Kassa J , Karasova JZ , Kuca K , Musilek K
Ref : Drug & Chemical Toxicology , 33 :227 , 2010
Abstract :
PubMedSearch : Kassa_2010_Drug.Chem.Toxicol_33_227
PubMedID: 20429807

Title : Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment - Joosen_2010_Chem.Biol.Interact_188_255
Author(s) : Joosen MJ , van der Schans MJ , van Helden HP
Ref : Chemico-Biological Interactions , 188 :255 , 2010
Abstract :
PubMedSearch : Joosen_2010_Chem.Biol.Interact_188_255
PubMedID: 20599844

Title : In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048 - Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680
Author(s) : Pohanka M , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 24 :680 , 2009
Abstract :
PubMedSearch : Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680
PubMedID: 18825528

Title : Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime - Nurulain_2009_Neurotox.Res_16_60
Author(s) : Nurulain SM , Lorke DE , Hasan MY , Shafiullah M , Kuca K , Musilek K , Petroianu GA
Ref : Neurotox Res , 16 :60 , 2009
Abstract :
PubMedSearch : Nurulain_2009_Neurotox.Res_16_60
PubMedID: 19526299

Title : Obidoxime in acute organophosphate poisoning: 2 - PK\/PD relationships - Thiermann_2009_Clin.Toxicol.(Phila)_47_807
Author(s) : Thiermann H , Worek F , Eyer P , Eyer F , Felgenhauer N , Zilker T
Ref : Clinical Toxicology (Phila) , 47 :807 , 2009
Abstract :
PubMedSearch : Thiermann_2009_Clin.Toxicol.(Phila)_47_807
PubMedID: 19778190

Title : A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_346
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K
Ref : Toxicol Mech Methods , 19 :346 , 2009
Abstract :
PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_346
PubMedID: 19778210

Title : Comments on Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI 6 -
Author(s) : Theirmann H , Worek F , Eyer P
Ref : Toxicol Mech Methods , 19 :334\; author reply 335 , 2009
PubMedID: 19778225

Title : Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 - Lorke_2009_Toxicol.Mech.Methods_19_327
Author(s) : Lorke DE , Hasan MY , Nurulain SM , Kuca K , Schmitt A , Petroianu GA
Ref : Toxicol Mech Methods , 19 :327 , 2009
Abstract :
PubMedSearch : Lorke_2009_Toxicol.Mech.Methods_19_327
PubMedID: 19778224

Title : An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Clin.Toxicol.(Phila)_47_72
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Bajgar J
Ref : Clinical Toxicology (Phila) , 47 :72 , 2009
Abstract :
PubMedSearch : Kassa_2009_Clin.Toxicol.(Phila)_47_72
PubMedID: 18686075

Title : Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness - Eyer_2009_Clin.Toxicol.(Phila)_47_798
Author(s) : Eyer F , Worek F , Eyer P , Felgenhauer N , Haberkorn M , Zilker T , Thiermann H
Ref : Clinical Toxicology (Phila) , 47 :798 , 2009
Abstract :
PubMedSearch : Eyer_2009_Clin.Toxicol.(Phila)_47_798
PubMedID: 19778163

Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008
Abstract :
PubMedSearch : Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70
PubMedID: 18341256

Title : An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Toxicology_243_311
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K
Ref : Toxicology , 243 :311 , 2008
Abstract :
PubMedSearch : Kassa_2008_Toxicology_243_311
PubMedID: 18054821

Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats - Kassa_2008_Chem.Biol.Interact_175_425
Author(s) : Kassa J , Jun D , Karasova J , Bajgar J , Kuca K
Ref : Chemico-Biological Interactions , 175 :425 , 2008
Abstract :
PubMedSearch : Kassa_2008_Chem.Biol.Interact_175_425
PubMedID: 18547554

Title : A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Drug.Chem.Toxicol_31_371
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Jung YS
Ref : Drug & Chemical Toxicology , 31 :371 , 2008
Abstract :
PubMedSearch : Kassa_2008_Drug.Chem.Toxicol_31_371
PubMedID: 18622871

Title : Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity - Lorke_2008_J.Appl.Toxicol_28_920
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Musilek K , Petroianu GA
Ref : J Appl Toxicol , 28 :920 , 2008
Abstract :
PubMedSearch : Lorke_2008_J.Appl.Toxicol_28_920
PubMedID: 18548743

Title : Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q) - Stenzel_2007_Biochem.Pharmacol_74_1390
Author(s) : Stenzel J , Worek F , Eyer P
Ref : Biochemical Pharmacology , 74 :1390 , 2007
Abstract :
PubMedSearch : Stenzel_2007_Biochem.Pharmacol_74_1390
PubMedID: 17714697

Title : Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro - Worek_2007_J.Appl.Toxicol_27_582
Author(s) : Worek F , Aurbek N , Thiermann H
Ref : J Appl Toxicol , 27 :582 , 2007
Abstract :
PubMedSearch : Worek_2007_J.Appl.Toxicol_27_582
PubMedID: 17370251

Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
Author(s) : Musilek K , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007
Abstract :
PubMedSearch : Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
PubMedID: 18254274

Title : Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon - Petroianu_2007_J.Appl.Toxicol_27_453
Author(s) : Petroianu GA , Nurulain SM , Nagelkerke N , Shafiullah M , Kassa J , Kuca K
Ref : J Appl Toxicol , 27 :453 , 2007
Abstract :
PubMedSearch : Petroianu_2007_J.Appl.Toxicol_27_453
PubMedID: 17304644

Title : A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) to counteract soman-induced neurotoxicity in rats - Kassa_2007_Drug.Chem.Toxicol_30_117
Author(s) : Kassa J , Karasova J
Ref : Drug & Chemical Toxicology , 30 :117 , 2007
Abstract :
PubMedSearch : Kassa_2007_Drug.Chem.Toxicol_30_117
PubMedID: 17454028

Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats - Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297
Author(s) : Kassa J , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 22 :297 , 2007
Abstract :
PubMedSearch : Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297
PubMedID: 17674811

Title : A Comparison of Newly Synthesized Oximes (K074, K075) and Oximes Introduced into the Czech Army (Obidoxime, HI-6) to Reactivate Tabun or Soman-Inhibited Acetylcholinesterase in Rat's Blood and Brain - Kassa_2007_Mil.Med.Sci.Lett_76_27
Author(s) : Kassa J , Jun D
Ref : Military Medical Science Letters , 76 :27 , 2007
Abstract :
PubMedSearch : Kassa_2007_Mil.Med.Sci.Lett_76_27
PubMedID:

Title : Hydrolysis of acetylthiocholine iodide and reactivation of phoxim-inhibited acetylcholinesterase by pralidoxime chloride, obidoxime chloride and trimedoxime - Zhang_2007_Arch.Toxicol_81_785
Author(s) : Zhang YH , Miyata T , Wu ZJ , Wu G , Xie LH
Ref : Archives of Toxicology , 81 :785 , 2007
Abstract :
PubMedSearch : Zhang_2007_Arch.Toxicol_81_785
PubMedID: 17534602

Title : In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase - Kuca_2006_J.Toxicol.Environ.Health.A_69_1431
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : J Toxicol Environ Health A , 69 :1431 , 2006
Abstract :
PubMedSearch : Kuca_2006_J.Toxicol.Environ.Health.A_69_1431
PubMedID: 16766478

Title : The liberation of thiocholine from acetylthiocholine (ASCh) by pralidoxime iodide (2=PAM) and other oximes (obidoxime and diacetylmonoxime) -
Author(s) : Worek F , Eyer P
Ref : Toxicol Lett , 167 :256 , 2006
PubMedID: 17113251

Title : Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates - Ekstrom_2006_Biochem.Pharmacol_72_597
Author(s) : Ekstrom F , Pang YP , Boman M , Artursson E , Akfur C , Borjegren S
Ref : Biochemical Pharmacology , 72 :597 , 2006
Abstract :
PubMedSearch : Ekstrom_2006_Biochem.Pharmacol_72_597
PubMedID: 16876764
Gene_locus related to this paper: mouse-ACHE

Title : A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : Acta Medica (Hradec Kralove) , 48 :81 , 2005
Abstract :
PubMedSearch : Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81
PubMedID: 16259317

Title : A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_J.Toxicol.Environ.Health.A_68_677
Author(s) : Kuca K , Cabal J , Kassa J
Ref : J Toxicol Environ Health A , 68 :677 , 2005
Abstract :
PubMedSearch : Kuca_2005_J.Toxicol.Environ.Health.A_68_677
PubMedID: 15901095

Title : Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain - Kuca_2005_J.Appl.Toxicol_25_271
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : J Appl Toxicol , 25 :271 , 2005
Abstract :
PubMedSearch : Kuca_2005_J.Appl.Toxicol_25_271
PubMedID: 16021679

Title : Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1) - Kiderlen_2005_Biochem.Pharmacol_69_1853
Author(s) : Kiderlen D , Eyer P , Worek F
Ref : Biochemical Pharmacology , 69 :1853 , 2005
Abstract :
PubMedSearch : Kiderlen_2005_Biochem.Pharmacol_69_1853
PubMedID: 15876422

Title : Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase - Herkenhoff_2004_Arch.Toxicol_78_338
Author(s) : Herkenhoff S , Szinicz L , Rastogi VK , Cheng TC , DeFrank JJ , Worek F
Ref : Archives of Toxicology , 78 :338 , 2004
Abstract :
PubMedSearch : Herkenhoff_2004_Arch.Toxicol_78_338
PubMedID: 14985944

Title : Beneficial late administration of obidoxime in malathion poisoning - Bentur_2003_Vet.Hum.Toxicol_45_33
Author(s) : Bentur Y , Raikhlin-Eisenkraft B , Singer P
Ref : Vet Hum Toxicol , 45 :33 , 2003
Abstract :
PubMedSearch : Bentur_2003_Vet.Hum.Toxicol_45_33
PubMedID: 12583695

Title : Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients - Grasshoff_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_203
Author(s) : Grasshoff C , Thiermann H , Gillessen T , Zilker T , Szinicz L
Ref : Journal of Chromatography B Biomed Sci Appl , 753 :203 , 2001
Abstract :
PubMedSearch : Grasshoff_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_203
PubMedID: 11334332

Title : [Comparison of the reactivating effect of BI-6, a new asymmetrical bispyridinium oxime, with oxime HI-6 and obidoxime on soman-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats] - Kassa_1999_Cas.Lek.Cesk_138_532
Author(s) : Kassa J , Bajgar J
Ref : Casopis Lekaru Ceskych , 138 :532 , 1999
Abstract :
PubMedSearch : Kassa_1999_Cas.Lek.Cesk_138_532
PubMedID: 10566233

Title : [Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice] - Kassa_1999_Ceska.Slov.Farm_48_44
Author(s) : Kassa J
Ref : Ceska a Slovenska Farmacie , 48 :44 , 1999
Abstract :
PubMedSearch : Kassa_1999_Ceska.Slov.Farm_48_44
PubMedID: 10376416

Title : A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods - Kassa_1999_Toxicology_132_111
Author(s) : Kassa J , Cabal J
Ref : Toxicology , 132 :111 , 1999
Abstract :
PubMedSearch : Kassa_1999_Toxicology_132_111
PubMedID: 10433374

Title : A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice - Kassa_1998_Acta.Medica_41_19
Author(s) : Kassa J
Ref : Acta Medica , 41 :19 , 1998
Abstract :
PubMedSearch : Kassa_1998_Acta.Medica_41_19
PubMedID: 9588068

Title : A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats - Kassa_1998_Hum.Exp.Toxicol_17_331
Author(s) : Kassa J
Ref : Hum Exp Toxicol , 17 :331 , 1998
Abstract :
PubMedSearch : Kassa_1998_Hum.Exp.Toxicol_17_331
PubMedID: 9688357

Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237
Author(s) : Worek F , Widmann R , Knopff O , Szinicz L
Ref : Archives of Toxicology , 72 :237 , 1998
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PubMedSearch : Worek_1998_Arch.Toxicol_72_237
PubMedID: 9587020

Title : Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients - Thiermann_1997_Hum.Exp.Toxicol_16_473
Author(s) : Thiermann H , Mast U , Klimmek R , Eyer P , Hibler A , Pfab R , Felgenhauer N , Zilker T
Ref : Hum Exp Toxicol , 16 :473 , 1997
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PubMedSearch : Thiermann_1997_Hum.Exp.Toxicol_16_473
PubMedID: 9292288

Title : Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning [editorial] -
Author(s) : Zilker T , Felgenhauer N , Hibler A , Pfab R , Thiermann H , Worek F , Eyer P
Ref : Przegl Lek , 54 :662 , 1997
PubMedID: 9478082

Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466
Author(s) : Worek F , Backer M , Thiermann H , Szinicz L , Mast U , Klimmek R , Eyer P
Ref : Hum Exp Toxicol , 16 :466 , 1997
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PubMedSearch : Worek_1997_Hum.Exp.Toxicol_16_466
PubMedID: 9292287

Title : Acute, severe cholinesterase inhibitors poisonings in the material of occupational diseases and toxicology ward in Poznan - Perlik-Gattner_1997_Przegl.Lek_54_756
Author(s) : Perlik-Gattner I , Kostrzewa A
Ref : Przegl Lek , 54 :756 , 1997
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PubMedSearch : Perlik-Gattner_1997_Przegl.Lek_54_756
PubMedID: 9478102

Title : The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice - Kassa_1997_Pharmacol.Toxicol_81_144
Author(s) : Kassa J , Bielavsky J
Ref : Pharmacol Toxicol , 81 :144 , 1997
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PubMedSearch : Kassa_1997_Pharmacol.Toxicol_81_144
PubMedID: 9335072

Title : Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors - Gnagey_1996_Biochem.Pharmacol_52_1767
Author(s) : Gnagey AL , Ellis J
Ref : Biochemical Pharmacology , 52 :1767 , 1996
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PubMedSearch : Gnagey_1996_Biochem.Pharmacol_52_1767
PubMedID: 8986140

Title : [Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice] - Kassa_1996_Ceska.Slov.Farm_45_31
Author(s) : Kassa J , Bajgar J
Ref : Ceska a Slovenska Farmacie , 45 :31 , 1996
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PubMedSearch : Kassa_1996_Ceska.Slov.Farm_45_31
PubMedID: 8620316

Title : Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats - Kassa_1995_Toxicology_101_167
Author(s) : Kassa J
Ref : Toxicology , 101 :167 , 1995
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PubMedID: 7676463

Title : Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats - Kassa_1995_Human.Exp.Toxicol_14_923
Author(s) : Kassa J , Bajgar J
Ref : Hum Exp Toxicol , 14 :923 , 1995
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PubMedSearch : Kassa_1995_Human.Exp.Toxicol_14_923
PubMedID: 8588955

Title : Poster: Hexamethonium and obidoxime antagonize the allosteric actions of alcuronium, W84, WDUO3, and gallamine at cardiac M2-receptors -
Author(s) : Trankle C , Mohr K
Ref : Life Sciences , 56(11-12) :1010 , 1995
PubMedID:

Title : Oxime effects on the rate constants of carbamylation and decarbamylation of acetylcholinesterase for pyridostigmine, physostigmine and insecticidal carbamates - Dawson_1995_Neurochem.Int_26_643
Author(s) : Dawson RM
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PubMedID: 7670367

Title : [Comparison of the effect of selected cholinesterase reactivators combined with atropine on soman and fosdrin toxicity in mice] - Kassa_1995_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove.Suppl_38_63
Author(s) : Kassa J
Ref : Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl , 38 :63 , 1995
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PubMedSearch : Kassa_1995_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove.Suppl_38_63
PubMedID: 9441373

Title : Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLo-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats - van Helden_1994_Arch.Toxicol_68_224
Author(s) : van Helden HP , van der Wiel HJ , Zijlstra JJ , Melchers BP , Busker RW
Ref : Archives of Toxicology , 68 :224 , 1994
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PubMedSearch : van Helden_1994_Arch.Toxicol_68_224
PubMedID: 8067894

Title : Interaction of obidoxime with sarin in aqueous solution - Waser_1992_Arch.Toxicol_66_211
Author(s) : Waser PG , Alioth-Streichenberg CM , Hopff WH , Portmann R , Hofmann W , Niederhauser A
Ref : Archives of Toxicology , 66 :211 , 1992
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PubMedSearch : Waser_1992_Arch.Toxicol_66_211
PubMedID: 1497486

Title : Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats - Alioth-Streichenberg_1991_Toxicol.Appl.Pharmacol_108_509
Author(s) : Alioth-Streichenberg CM , Bodmer DM , Waser PG
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PubMedSearch : Alioth-Streichenberg_1991_Toxicol.Appl.Pharmacol_108_509
PubMedID: 2020972

Title : A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro - Alberts_1990_Eur.J.Pharmacol_184_191
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Ref : European Journal of Pharmacology , 184 :191 , 1990
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PubMedSearch : Alberts_1990_Eur.J.Pharmacol_184_191
PubMedID: 2209712

Title : Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice - Kaliste-Korhonen_1989_Gen.Pharmacol_20_805
Author(s) : Kaliste-Korhonen E , Ryhanen R , Ylitalo P , Hanninen O
Ref : General Pharmacology , 20 :805 , 1989
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PubMedID: 2687080

Title : Side effects of therapeutic drugs against organophosphate poisoning - Wolthuis_1989_Neurotoxicol.Teratol_11_221
Author(s) : Wolthuis OL , Philippens IH , Vanwersch RA
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PubMedSearch : Wolthuis_1989_Neurotoxicol.Teratol_11_221
PubMedID: 2666846

Title : Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime - Puu_1986_Biochem.Pharmacol_35_1505
Author(s) : Puu G , Artursson E , Bucht G
Ref : Biochemical Pharmacology , 35 :1505 , 1986
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PubMedSearch : Puu_1986_Biochem.Pharmacol_35_1505
PubMedID: 3518721

Title : Pharmacokinetics of [14C]-Sarin and Its Changes by Obidoxime and Pralidoxime -
Author(s) : Waser PG , Sammett R , Schonenberger E , Chang Sin-Ren AC
Ref : Advances in Behavioral Biology , 30 :743 , 1986
PubMedID:

Title : Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators - Xue_1985_Scand.J.Work.Environ.Health_4_46
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Ref : Scandinavian Journal of Work, Environment & Health , 4 :46 , 1985
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PubMedID: 3914075

Title : Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions - Caratsch_1984_Pflugers.Arch_401_84
Author(s) : Caratsch CG , Waser PG
Ref : Pflugers Arch , 401 :84 , 1984
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PubMedSearch : Caratsch_1984_Pflugers.Arch_401_84
PubMedID: 6382149

Title : Obidoxime reactivation of organophosphate-inhibited cholinesterase activity in pigs -
Author(s) : Gyrd-Hansen N , Kraul I
Ref : Acta Vet Scand , 25 :86 , 1984
PubMedID: 6380243

Title : Poisoning by di-isopropylfluorophosphate (DFP) in mice: central cholinergic systems involved in the antidotal action of obidoxime and diazepam -
Author(s) : Meneguz A , Michalek H
Ref : Farmacorat , 34 :523 , 1979
PubMedID: 399921

Title : Acetylcholine and cholinesterase in submandibular glands of rats given armin and obidoxime - Vasic_1978_J.Dent.Res_57_748
Author(s) : Vasic BV , Milosevic MP , Terzic MR
Ref : J Dent Res , 57 :748 , 1978
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PubMedSearch : Vasic_1978_J.Dent.Res_57_748
PubMedID: 359615

Title : Acetylcholine content and cholinesterase activity in the ponto-medullary region of brain in rats treated with armin and obidoxime -
Author(s) : Vasic B , Milosevic MP , Terzic MR
Ref : Biochemical Pharmacology , 26 :601 , 1977
PubMedID: 324475

Title : Administration of obidoxime tablets to man. Plasma levels and side reactions - Simon_1976_Arch.Toxicol_36_83
Author(s) : Simon GA , Tirosh MS , Edery H
Ref : Archives of Toxicology , 36 :83 , 1976
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PubMedSearch : Simon_1976_Arch.Toxicol_36_83
PubMedID: 788681

Title : [Effect of some reactivators on cholinesterase activity in the chromodacryorrhea test in rats]. [Bulgarian] - Naneva_1976_Vet.Med.Nauki_13_81
Author(s) : Naneva E
Ref : Veterinarno Meditsinski Nauki , 13 :81 , 1976
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Title : [Effect of arpenal on the EMG-potentials of the anterior tibial muscle in cats during acute phosdrine poisoning] - Mashkova_1976_Eksp.Med.Morfol_15_237
Author(s) : Mashkova D
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PubMedSearch : Mashkova_1976_Eksp.Med.Morfol_15_237
PubMedID: 1017412

Title : Studies on the protective action of atropine and obidoxime against sarin poisoning in mice -
Author(s) : Borbely AA , Junod U , Hopff WH , Hofmann A , Yaney R , Waser PG
Ref : Cholinergic.Mechanisms, Raven Press :427 , 1975
PubMedID:

Title : [Reactivating effect of trimedoxime and obidoxime on cholinesterases inhibited in the heart and intercostal muscles of the rat during acute poisoning with O-ethyl-S-(dimethylaminethyl)-methylthiophosphonate. (A histochemical study)]. [Czech] -
Author(s) : Picha B
Ref : Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove , 17 :195 , 1974
PubMedID: 4620479

Title : Effects of obidoxime on content and synthesis of brain acetylcholine in DFP intoxicated rats -
Author(s) : Michalek H , Bonavoglia F
Ref : Biochemical Pharmacology , 22 :3124 , 1973
PubMedID: 4586722

Title : Failure of toxogonin to reactivate soman-inhibited brain acetylcholinesterase in monkeys and regeneration of the enzyme -
Author(s) : Filbert MG , Fleisher JH , Lochner MA
Ref : Biochimica & Biophysica Acta , 284 :164 , 1972
PubMedID: 4627450

Title : Toxogonin and pralidoxime: kinetic comparison after intravenous administration to man -
Author(s) : Sidell FR , Groff WA , Kaminskis A
Ref : Journal of Pharmaceutical Sciences , 61 :1765 , 1972
PubMedID: 4569114

Title : Hydrolysis of obidoxime chloride (Toxogonin). 3. Kinetics in neutral and alkaline solution -
Author(s) : Christenson I
Ref : Acta Pharm Suec , 9 :309 , 1972
PubMedID: 4570327

Title : Characterization of cholinesterases in various tissues of guinea pig with respect to their reactivation by obidoxime after inactivation by diisopropylfluorophosphate -
Author(s) : Alsen C , Ohnesorge FK
Ref : Arch Toxikol , 29 :235 , 1972
PubMedID: 4566010

Title : Effects of DFP and Obidoxime on brain acetylcholine levels and on brain and peripheral cholinesterases -
Author(s) : Mayer O , Michalek H , Mayer 0
Ref : Biochemical Pharmacology , 20 :3029 , 1971
PubMedID: 4943596

Title : Toxogonin: oral administration to man -
Author(s) : Sidell FR , Groff WA
Ref : Journal of Pharmaceutical Sciences , 60 :860 , 1971
PubMedID: 4942862

Title : Acetylcholine content in the brain of rats treated with paraoxon and obidoxime - Milosevic_1970_Br.J.Pharmacol_39_732
Author(s) : Milosevic MP
Ref : British Journal of Pharmacology , 39 :732 , 1970
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PubMedSearch : Milosevic_1970_Br.J.Pharmacol_39_732
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Title : [Treatment of parathion (E 605) poisoning with the cholinesterase-reactivating substance obidoxime (Toxogonin)] -
Author(s) : Barckow D , Neuhaus G , Erdmann WD
Ref : Arch Toxikol , 24 :133 , 1969
PubMedID: 5764880