Toxogonin
General
Type : Oxime, Bisoxime, Bispyridinium
Chemical_Nomenclature : oxo-[[1-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxymethyl]pyridin-4-ylidene]methyl]azanium\;dichloride
Canonical SMILES : C1=CN(C=CC1=C[NH+]=O)COCN2C=CC(=C[NH+]=O)C=C2.[Cl-].[Cl-]
InChI : InChI=1S\/C14H14N4O3.2ClH\/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20\;\;\/h1-10H,11-12H2\;2*1H
InChIKey : ZIFJVJZWVSPZLE-UHFFFAOYSA-N
Other name(s) : Obidoxime Chloride || Lo-6 || Obidoxime || Obidoxim || Toxogonine || DMO4 || LuH6 || Lu6 || 1,1'-[Oxysbis(methylene)bis[$-(hydroxyimino)methyl]pyridinium dichloride || 1,1'-oxydimethylene bis -[4-formyl pyridinium bromide]dioxime
Target
Structure : 2GYW
Families : No family
References (95)
| Title : The reactivation kinetic analysis, molecular docking, and dynamics of oximes against three V-type nerve agents inhibited four human cholinesterases - Li_2024_Chem.Biol.Interact__111061 |
| Author(s) : Li K , Liu Y , Li Q , Guo L , Xie J |
| Ref : Chemico-Biological Interactions , :111061 , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Chem.Biol.Interact__111061 |
| PubMedID: 38763347 |
| Title : The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime - Lorke_2019_Front.Neurosci_13_427 |
| Author(s) : Lorke DE , Petroianu GA |
| Ref : Front Neurosci , 13 :427 , 2019 |
| Abstract : |
| PubMedSearch : Lorke_2019_Front.Neurosci_13_427 |
| PubMedID: 31191210 |
| Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
| Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC |
| Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019 |
| Abstract : |
| PubMedSearch : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
| PubMedID: 31074292 |
| Title : Efficacy of atropine sulfate\/obidoxime chloride co-formulation against sarin exposure in guinea pigs - Joosen_2018_Chem.Biol.Interact_296_34 |
| Author(s) : Joosen MJ , Klaassen SD , Verheij E , van Groningen T , Cornelissen AS , Skiadopoulos MH , Cochrane L , Shearer JD |
| Ref : Chemico-Biological Interactions , 296 :34 , 2018 |
| Abstract : |
| PubMedSearch : Joosen_2018_Chem.Biol.Interact_296_34 |
| PubMedID: 30217478 |
| Title : Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6 - Wille_2017_Arch.Toxicol_91_1309 |
| Author(s) : Wille T , von der Wellen J , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 91 :1309 , 2017 |
| Abstract : |
| PubMedSearch : Wille_2017_Arch.Toxicol_91_1309 |
| PubMedID: 27358236 |
| Title : Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning - Krishnan_2016_Neurotoxicol_53_64 |
| Author(s) : Krishnan JK , Arun P , Appu AP , Vijayakumar N , Figueiredo TH , Braga MF , Baskota S , Olsen CH , Farkas N , Dagata J , Frey WH, 2nd , Moffett JR , Namboodiri AM |
| Ref : Neurotoxicology , 53 :64 , 2016 |
| Abstract : |
| PubMedSearch : Krishnan_2016_Neurotoxicol_53_64 |
| PubMedID: 26751814 |
| Title : Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics - Worek_2016_Toxicology_350-352_25 |
| Author(s) : Worek F , Koller M , Thiermann H , Wille T |
| Ref : Toxicology , 350-352 :25 , 2016 |
| Abstract : |
| PubMedSearch : Worek_2016_Toxicology_350-352_25 |
| PubMedID: 27153754 |
| Title : Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report - Steinritz_2016_Toxicol.Lett_244_121 |
| Author(s) : Steinritz D , Eyer F , Worek F , Thiermann H , John H |
| Ref : Toxicol Lett , 244 :121 , 2016 |
| Abstract : |
| PubMedSearch : Steinritz_2016_Toxicol.Lett_244_121 |
| PubMedID: 26200596 |
| Title : A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice - Kassa_2015_Toxicol.Mech.Methods_25_229 |
| Author(s) : Kassa J , Sepsova V , Matouskova L , Horova A , Musilek K |
| Ref : Toxicol Mech Methods , 25 :229 , 2015 |
| Abstract : |
| PubMedSearch : Kassa_2015_Toxicol.Mech.Methods_25_229 |
| PubMedID: 25894563 |
| Title : Pd(II) complexes of acetylcholinesterase reactivator obidoxime - Nedzhib_2014_Interdiscip.Toxicol_7_139 |
| Author(s) : Nedzhib A , Stoykova S , Atanasov V , Pantcheva I , Antonov L |
| Ref : Interdiscip Toxicol , 7 :139 , 2014 |
| Abstract : |
| PubMedSearch : Nedzhib_2014_Interdiscip.Toxicol_7_139 |
| PubMedID: 26109891 |
| Title : A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice - Kassa_2010_Drug.Chem.Toxicol_33_227 |
| Author(s) : Kassa J , Karasova JZ , Kuca K , Musilek K |
| Ref : Drug & Chemical Toxicology , 33 :227 , 2010 |
| Abstract : |
| PubMedSearch : Kassa_2010_Drug.Chem.Toxicol_33_227 |
| PubMedID: 20429807 |
| Title : Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment - Joosen_2010_Chem.Biol.Interact_188_255 |
| Author(s) : Joosen MJ , van der Schans MJ , van Helden HP |
| Ref : Chemico-Biological Interactions , 188 :255 , 2010 |
| Abstract : |
| PubMedSearch : Joosen_2010_Chem.Biol.Interact_188_255 |
| PubMedID: 20599844 |
| Title : A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques - Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790 |
| Author(s) : Bajgar J , Hajek P , Karasova JZ , Kassa J , Paseka A , Slizova D , Krs O , Kuca K , Jun D , Fusek J , Capek L |
| Ref : J Enzyme Inhib Med Chem , 25 :790 , 2010 |
| Abstract : |
| PubMedSearch : Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790 |
| PubMedID: 21054236 |
| Title : Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds - Thiermann_2010_Toxicol.Lett_197_236 |
| Author(s) : Thiermann H , Eyer F , Felgenhauer N , Pfab R , Zilker T , Eyer P , Worek F |
| Ref : Toxicol Lett , 197 :236 , 2010 |
| Abstract : |
| PubMedSearch : Thiermann_2010_Toxicol.Lett_197_236 |
| PubMedID: 20542100 |
| Title : Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration - Karasova_2010_Anal.Sci_26_63 |
| Author(s) : Karasova JZ , Novotny L , Antos K , Zivna H , Kuca K |
| Ref : Anal Sci , 26 :63 , 2010 |
| Abstract : |
| PubMedSearch : Karasova_2010_Anal.Sci_26_63 |
| PubMedID: 20065589 |
| Title : A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats - Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861 |
| Author(s) : Kassa J , Karasova JZ , Tesarova S , Musilek K , Kuca K , Jung YS |
| Ref : Basic Clin Pharmacol Toxicol , 107 :861 , 2010 |
| Abstract : |
| PubMedSearch : Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861 |
| PubMedID: 22545968 |
| Title : A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice - Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480 |
| Author(s) : Kassa J , Karasova JZ , Caisberger F , Musilek K , Kuca K , Jung YS |
| Ref : J Enzyme Inhib Med Chem , 25 :480 , 2010 |
| Abstract : |
| PubMedSearch : Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480 |
| PubMedID: 20233085 |
| Title : Characterization of the anticholinergic properties of obidoxime\; functional examinations of the rat atria and the urinary bladder - Soukup_2010_Toxicol.Mech.Methods_20_428 |
| Author(s) : Soukup O , Tobin G , Kumar UK , Jun D , Fusek J , Kuca K |
| Ref : Toxicol Mech Methods , 20 :428 , 2010 |
| Abstract : |
| PubMedSearch : Soukup_2010_Toxicol.Mech.Methods_20_428 |
| PubMedID: 20602545 |
| Title : Comments on Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI 6 - |
| Author(s) : Theirmann H , Worek F , Eyer P |
| Ref : Toxicol Mech Methods , 19 :334\; author reply 335 , 2009 |
| PubMedID: 19778225 |
| Title : Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 - Lorke_2009_Toxicol.Mech.Methods_19_327 |
| Author(s) : Lorke DE , Hasan MY , Nurulain SM , Kuca K , Schmitt A , Petroianu GA |
| Ref : Toxicol Mech Methods , 19 :327 , 2009 |
| Abstract : |
| PubMedSearch : Lorke_2009_Toxicol.Mech.Methods_19_327 |
| PubMedID: 19778224 |
| Title : An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Clin.Toxicol.(Phila)_47_72 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Bajgar J |
| Ref : Clinical Toxicology (Phila) , 47 :72 , 2009 |
| Abstract : |
| PubMedSearch : Kassa_2009_Clin.Toxicol.(Phila)_47_72 |
| PubMedID: 18686075 |
| Title : Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness - Eyer_2009_Clin.Toxicol.(Phila)_47_798 |
| Author(s) : Eyer F , Worek F , Eyer P , Felgenhauer N , Haberkorn M , Zilker T , Thiermann H |
| Ref : Clinical Toxicology (Phila) , 47 :798 , 2009 |
| Abstract : |
| PubMedSearch : Eyer_2009_Clin.Toxicol.(Phila)_47_798 |
| PubMedID: 19778163 |
| Title : In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048 - Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680 |
| Author(s) : Pohanka M , Jun D , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 24 :680 , 2009 |
| Abstract : |
| PubMedSearch : Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680 |
| PubMedID: 18825528 |
| Title : Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime - Nurulain_2009_Neurotox.Res_16_60 |
| Author(s) : Nurulain SM , Lorke DE , Hasan MY , Shafiullah M , Kuca K , Musilek K , Petroianu GA |
| Ref : Neurotox Res , 16 :60 , 2009 |
| Abstract : |
| PubMedSearch : Nurulain_2009_Neurotox.Res_16_60 |
| PubMedID: 19526299 |
| Title : Obidoxime in acute organophosphate poisoning: 2 - PK\/PD relationships - Thiermann_2009_Clin.Toxicol.(Phila)_47_807 |
| Author(s) : Thiermann H , Worek F , Eyer P , Eyer F , Felgenhauer N , Zilker T |
| Ref : Clinical Toxicology (Phila) , 47 :807 , 2009 |
| Abstract : |
| PubMedSearch : Thiermann_2009_Clin.Toxicol.(Phila)_47_807 |
| PubMedID: 19778190 |
| Title : A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_346 |
| Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K |
| Ref : Toxicol Mech Methods , 19 :346 , 2009 |
| Abstract : |
| PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_346 |
| PubMedID: 19778210 |
| Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats - Kassa_2008_Chem.Biol.Interact_175_425 |
| Author(s) : Kassa J , Jun D , Karasova J , Bajgar J , Kuca K |
| Ref : Chemico-Biological Interactions , 175 :425 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Chem.Biol.Interact_175_425 |
| PubMedID: 18547554 |
| Title : A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Drug.Chem.Toxicol_31_371 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Jung YS |
| Ref : Drug & Chemical Toxicology , 31 :371 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Drug.Chem.Toxicol_31_371 |
| PubMedID: 18622871 |
| Title : Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity - Lorke_2008_J.Appl.Toxicol_28_920 |
| Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Musilek K , Petroianu GA |
| Ref : J Appl Toxicol , 28 :920 , 2008 |
| Abstract : |
| PubMedSearch : Lorke_2008_J.Appl.Toxicol_28_920 |
| PubMedID: 18548743 |
| Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70 |
| Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M |
| Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008 |
| Abstract : |
| PubMedSearch : Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70 |
| PubMedID: 18341256 |
| Title : An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Toxicology_243_311 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K |
| Ref : Toxicology , 243 :311 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Toxicology_243_311 |
| PubMedID: 18054821 |
| Title : A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) to counteract soman-induced neurotoxicity in rats - Kassa_2007_Drug.Chem.Toxicol_30_117 |
| Author(s) : Kassa J , Karasova J |
| Ref : Drug & Chemical Toxicology , 30 :117 , 2007 |
| Abstract : |
| PubMedSearch : Kassa_2007_Drug.Chem.Toxicol_30_117 |
| PubMedID: 17454028 |
| Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats - Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297 |
| Author(s) : Kassa J , Jun D , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 22 :297 , 2007 |
| Abstract : |
| PubMedSearch : Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297 |
| PubMedID: 17674811 |
| Title : A Comparison of Newly Synthesized Oximes (K074, K075) and Oximes Introduced into the Czech Army (Obidoxime, HI-6) to Reactivate Tabun or Soman-Inhibited Acetylcholinesterase in Rat's Blood and Brain - Kassa_2007_Mil.Med.Sci.Lett_76_27 |
| Author(s) : Kassa J , Jun D |
| Ref : Military Medical Science Letters , 76 :27 , 2007 |
| Abstract : |
| PubMedSearch : Kassa_2007_Mil.Med.Sci.Lett_76_27 |
| PubMedID: |
| Title : Hydrolysis of acetylthiocholine iodide and reactivation of phoxim-inhibited acetylcholinesterase by pralidoxime chloride, obidoxime chloride and trimedoxime - Zhang_2007_Arch.Toxicol_81_785 |
| Author(s) : Zhang YH , Miyata T , Wu ZJ , Wu G , Xie LH |
| Ref : Archives of Toxicology , 81 :785 , 2007 |
| Abstract : |
| PubMedSearch : Zhang_2007_Arch.Toxicol_81_785 |
| PubMedID: 17534602 |
| Title : Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q) - Stenzel_2007_Biochem.Pharmacol_74_1390 |
| Author(s) : Stenzel J , Worek F , Eyer P |
| Ref : Biochemical Pharmacology , 74 :1390 , 2007 |
| Abstract : |
| PubMedSearch : Stenzel_2007_Biochem.Pharmacol_74_1390 |
| PubMedID: 17714697 |
| Title : Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro - Worek_2007_J.Appl.Toxicol_27_582 |
| Author(s) : Worek F , Aurbek N , Thiermann H |
| Ref : J Appl Toxicol , 27 :582 , 2007 |
| Abstract : |
| PubMedSearch : Worek_2007_J.Appl.Toxicol_27_582 |
| PubMedID: 17370251 |
| Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203 |
| Author(s) : Musilek K , Kuca K , Jun D |
| Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203 |
| PubMedID: 18254274 |
| Title : Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon - Petroianu_2007_J.Appl.Toxicol_27_453 |
| Author(s) : Petroianu GA , Nurulain SM , Nagelkerke N , Shafiullah M , Kassa J , Kuca K |
| Ref : J Appl Toxicol , 27 :453 , 2007 |
| Abstract : |
| PubMedSearch : Petroianu_2007_J.Appl.Toxicol_27_453 |
| PubMedID: 17304644 |
| Title : In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase - Kuca_2006_J.Toxicol.Environ.Health.A_69_1431 |
| Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M |
| Ref : J Toxicol Environ Health A , 69 :1431 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_J.Toxicol.Environ.Health.A_69_1431 |
| PubMedID: 16766478 |
| Title : Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates - Ekstrom_2006_Biochem.Pharmacol_72_597 |
| Author(s) : Ekstrom F , Pang YP , Boman M , Artursson E , Akfur C , Borjegren S |
| Ref : Biochemical Pharmacology , 72 :597 , 2006 |
| Abstract : |
| PubMedSearch : Ekstrom_2006_Biochem.Pharmacol_72_597 |
| PubMedID: 16876764 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_J.Toxicol.Environ.Health.A_68_677 |
| Author(s) : Kuca K , Cabal J , Kassa J |
| Ref : J Toxicol Environ Health A , 68 :677 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_J.Toxicol.Environ.Health.A_68_677 |
| PubMedID: 15901095 |
| Title : Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain - Kuca_2005_J.Appl.Toxicol_25_271 |
| Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M |
| Ref : J Appl Toxicol , 25 :271 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_J.Appl.Toxicol_25_271 |
| PubMedID: 16021679 |
| Title : Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1) - Kiderlen_2005_Biochem.Pharmacol_69_1853 |
| Author(s) : Kiderlen D , Eyer P , Worek F |
| Ref : Biochemical Pharmacology , 69 :1853 , 2005 |
| Abstract : |
| PubMedSearch : Kiderlen_2005_Biochem.Pharmacol_69_1853 |
| PubMedID: 15876422 |
| Title : A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81 |
| Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M |
| Ref : Acta Medica (Hradec Kralove) , 48 :81 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81 |
| PubMedID: 16259317 |
| Title : Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase - Herkenhoff_2004_Arch.Toxicol_78_338 |
| Author(s) : Herkenhoff S , Szinicz L , Rastogi VK , Cheng TC , DeFrank JJ , Worek F |
| Ref : Archives of Toxicology , 78 :338 , 2004 |
| Abstract : |
| PubMedSearch : Herkenhoff_2004_Arch.Toxicol_78_338 |
| PubMedID: 14985944 |
| Title : Beneficial late administration of obidoxime in malathion poisoning - Bentur_2003_Vet.Hum.Toxicol_45_33 |
| Author(s) : Bentur Y , Raikhlin-Eisenkraft B , Singer P |
| Ref : Vet Hum Toxicol , 45 :33 , 2003 |
| Abstract : |
| PubMedSearch : Bentur_2003_Vet.Hum.Toxicol_45_33 |
| PubMedID: 12583695 |
| Title : Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients - Grasshoff_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_203 |
| Author(s) : Grasshoff C , Thiermann H , Gillessen T , Zilker T , Szinicz L |
| Ref : Journal of Chromatography B Biomed Sci Appl , 753 :203 , 2001 |
| Abstract : |
| PubMedSearch : Grasshoff_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_203 |
| PubMedID: 11334332 |
| Title : [Comparison of the reactivating effect of BI-6, a new asymmetrical bispyridinium oxime, with oxime HI-6 and obidoxime on soman-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats] - Kassa_1999_Cas.Lek.Cesk_138_532 |
| Author(s) : Kassa J , Bajgar J |
| Ref : Casopis Lekaru Ceskych , 138 :532 , 1999 |
| Abstract : |
| PubMedSearch : Kassa_1999_Cas.Lek.Cesk_138_532 |
| PubMedID: 10566233 |
| Title : [Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice] - Kassa_1999_Ceska.Slov.Farm_48_44 |
| Author(s) : Kassa J |
| Ref : Ceska a Slovenska Farmacie , 48 :44 , 1999 |
| Abstract : |
| PubMedSearch : Kassa_1999_Ceska.Slov.Farm_48_44 |
| PubMedID: 10376416 |
| Title : A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods - Kassa_1999_Toxicology_132_111 |
| Author(s) : Kassa J , Cabal J |
| Ref : Toxicology , 132 :111 , 1999 |
| Abstract : |
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| Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237 |
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| Title : A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice - Kassa_1998_Acta.Medica_41_19 |
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| Title : A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats - Kassa_1998_Hum.Exp.Toxicol_17_331 |
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| Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466 |
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| Title : The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice - Kassa_1997_Pharmacol.Toxicol_81_144 |
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| Title : Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients - Thiermann_1997_Hum.Exp.Toxicol_16_473 |
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| Title : Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning [editorial] - |
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| Title : Acute, severe cholinesterase inhibitors poisonings in the material of occupational diseases and toxicology ward in Poznan - Perlik-Gattner_1997_Przegl.Lek_54_756 |
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| Title : Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors - Gnagey_1996_Biochem.Pharmacol_52_1767 |
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| Title : [Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice] - Kassa_1996_Ceska.Slov.Farm_45_31 |
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| Title : Oxime effects on the rate constants of carbamylation and decarbamylation of acetylcholinesterase for pyridostigmine, physostigmine and insecticidal carbamates - Dawson_1995_Neurochem.Int_26_643 |
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| Title : Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats - Kassa_1995_Toxicology_101_167 |
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| Title : Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats - Kassa_1995_Human.Exp.Toxicol_14_923 |
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| Title : Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLo-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats - van Helden_1994_Arch.Toxicol_68_224 |
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| Title : Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats - Alioth-Streichenberg_1991_Toxicol.Appl.Pharmacol_108_509 |
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| Title : Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice - Kaliste-Korhonen_1989_Gen.Pharmacol_20_805 |
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| Title : Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime - Puu_1986_Biochem.Pharmacol_35_1505 |
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| Title : Pharmacokinetics of [14C]-Sarin and Its Changes by Obidoxime and Pralidoxime - |
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| Title : Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators - Xue_1985_Scand.J.Work.Environ.Health_4_46 |
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| Title : Obidoxime reactivation of organophosphate-inhibited cholinesterase activity in pigs - |
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| Title : Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions - Caratsch_1984_Pflugers.Arch_401_84 |
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| Title : Poisoning by di-isopropylfluorophosphate (DFP) in mice: central cholinergic systems involved in the antidotal action of obidoxime and diazepam - |
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| Title : Acetylcholine and cholinesterase in submandibular glands of rats given armin and obidoxime - Vasic_1978_J.Dent.Res_57_748 |
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| Title : Acetylcholine content and cholinesterase activity in the ponto-medullary region of brain in rats treated with armin and obidoxime - |
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| Title : [Effect of arpenal on the EMG-potentials of the anterior tibial muscle in cats during acute phosdrine poisoning] - Mashkova_1976_Eksp.Med.Morfol_15_237 |
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| Title : Administration of obidoxime tablets to man. Plasma levels and side reactions - Simon_1976_Arch.Toxicol_36_83 |
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| Title : [Effect of some reactivators on cholinesterase activity in the chromodacryorrhea test in rats]. [Bulgarian] - Naneva_1976_Vet.Med.Nauki_13_81 |
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| Title : [Reactivating effect of trimedoxime and obidoxime on cholinesterases inhibited in the heart and intercostal muscles of the rat during acute poisoning with O-ethyl-S-(dimethylaminethyl)-methylthiophosphonate. (A histochemical study)]. [Czech] - |
| Author(s) : Picha B |
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| Title : Effects of obidoxime on content and synthesis of brain acetylcholine in DFP intoxicated rats - |
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| Title : Hydrolysis of obidoxime chloride (Toxogonin). 3. Kinetics in neutral and alkaline solution - |
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| Title : Characterization of cholinesterases in various tissues of guinea pig with respect to their reactivation by obidoxime after inactivation by diisopropylfluorophosphate - |
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| Title : Toxogonin and pralidoxime: kinetic comparison after intravenous administration to man - |
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| Title : Failure of toxogonin to reactivate soman-inhibited brain acetylcholinesterase in monkeys and regeneration of the enzyme - |
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| Title : Effects of DFP and Obidoxime on brain acetylcholine levels and on brain and peripheral cholinesterases - |
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| Title : Acetylcholine content in the brain of rats treated with paraoxon and obidoxime - Milosevic_1970_Br.J.Pharmacol_39_732 |
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| Title : [Treatment of parathion (E 605) poisoning with the cholinesterase-reactivating substance obidoxime (Toxogonin)] - |
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