Kim_2011_Nature_479_223

Reference

Title : Genome sequencing reveals insights into physiology and longevity of the naked mole rat - Kim_2011_Nature_479_223
Author(s) : Kim EB , Fang X , Fushan AA , Huang Z , Lobanov AV , Han L , Marino SM , Sun X , Turanov AA , Yang P , Yim SH , Zhao X , Kasaikina MV , Stoletzki N , Peng C , Polak P , Xiong Z , Kiezun A , Zhu Y , Chen Y , Kryukov GV , Zhang Q , Peshkin L , Yang L , Bronson RT , Buffenstein R , Wang B , Han C , Li Q , Chen L , Zhao W , Sunyaev SR , Park TJ , Zhang G , Wang J , Gladyshev VN
Ref : Nature , 479 :223 , 2011
Abstract :

The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

PubMedSearch : Kim_2011_Nature_479_223
PubMedID: 21993625
Gene_locus related to this paper: hetga-g5amh8 , hetga-g5an68 , hetga-g5anw7 , hetga-g5as32 , hetga-g5atg6 , hetga-g5b5b7 , hetga-g5b9m6 , hetga-g5bdh8 , hetga-g5bmv3 , hetga-g5bp66 , hetga-g5bp67 , hetga-g5bp68 , hetga-g5bpp3 , hetga-g5bsd4 , hetga-g5bul0 , hetga-g5bw29 , hetga-g5bze3 , hetga-g5c6q5 , hetga-g5bfw4 , hetga-g5b832 , hetga-g5c6q8 , hetga-g5bj87 , hetga-a0a0p6jix7 , hetga-g5c108 , hetga-g5c109 , hetga-g5c110 , hetga-g5arh0 , hetga-g5aua1 , hetga-g5are8 , hetga-g5ax31 , hetga-a0a0p6jud6 , hetga-g5b7v3 , hetga-a0a0p6jw61 , hetga-a0a0p6jdl4 , hetga-g5bg83 , hetga-g5bcu5 , hetga-g5bvp0 , hetga-g5b8m7 , hetga-g5b709 , hetga-g5bt99 , hetga-g5b4q4

Related information

Gene_locus hetga-g5amh8    hetga-g5an68    hetga-g5anw7    hetga-g5as32    hetga-g5atg6    hetga-g5b5b7    hetga-g5b9m6    hetga-g5bdh8    hetga-g5bmv3    hetga-g5bp66    hetga-g5bp67    hetga-g5bp68    hetga-g5bpp3    hetga-g5bsd4    hetga-g5bul0    hetga-g5bw29    hetga-g5bze3    hetga-g5c6q5    hetga-g5bfw4    hetga-g5b832    hetga-g5c6q8    hetga-g5bj87    hetga-a0a0p6jix7    hetga-g5c108    hetga-g5c109    hetga-g5c110    hetga-g5arh0    hetga-g5aua1    hetga-g5are8    hetga-g5ax31    hetga-a0a0p6jud6    hetga-g5b7v3    hetga-a0a0p6jw61    hetga-a0a0p6jdl4    hetga-g5bg83    hetga-g5bcu5    hetga-g5bvp0    hetga-g5b8m7    hetga-g5b709    hetga-g5bt99    hetga-g5b4q4
Gene_locus_frgt hetga-g5amh8    hetga-g5an68    hetga-g5anw7    hetga-g5as32    hetga-g5atg6    hetga-g5b5b7    hetga-g5b9m6    hetga-g5bdh8    hetga-g5bmv3    hetga-g5bp66    hetga-g5bp67    hetga-g5bp68    hetga-g5bpp3    hetga-g5bsd4    hetga-g5bul0    hetga-g5bw29    hetga-g5bze3    hetga-g5c6q5    hetga-g5bfw4    hetga-g5b832    hetga-g5c6q8    hetga-g5bj87    hetga-a0a0p6jix7    hetga-g5c108    hetga-g5c109    hetga-g5c110    hetga-g5arh0    hetga-g5aua1    hetga-g5are8    hetga-g5ax31    hetga-a0a0p6jud6    hetga-g5b7v3    hetga-a0a0p6jw61    hetga-a0a0p6jdl4    hetga-g5bg83    hetga-g5bcu5    hetga-g5bvp0    hetga-g5b8m7    hetga-g5b709    hetga-g5bt99    hetga-g5b4q4    hetga-g5amh6    hetga-g5amh9    hetga-g5anw9    hetga-g5as33    hetga-g5b5n9    hetga-g5bk95    hetga-g5bke7    hetga-g5bp65    hetga-g5bp69    hetga-g5byj4    hetga-g5anw8    hetga-g5alm4    hetga-g5bpp1    hetga-g5axn4    hetga-g5aky7    hetga-g5c8b6

Citations formats

Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN (2011)
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Nature 479 :223

Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN (2011)
Nature 479 :223