Kruse_2014_Nat.Rev.Drug.Discov_13_549

Reference

Title : Muscarinic acetylcholine receptors: novel opportunities for drug development - Kruse_2014_Nat.Rev.Drug.Discov_13_549
Author(s) : Kruse AC , Kobilka BK , Gautam D , Sexton PM , Christopoulos A , Wess J
Ref : Nat Rev Drug Discov , 13 :549 , 2014
Abstract : The muscarinic acetylcholine receptors are a subfamily of G protein-coupled receptors that regulate numerous fundamental functions of the central and peripheral nervous system. The past few years have witnessed unprecedented new insights into muscarinic receptor physiology, pharmacology and structure. These advances include the first structural views of muscarinic receptors in both inactive and active conformations, as well as a better understanding of the molecular underpinnings of muscarinic receptor regulation by allosteric modulators. These recent findings should facilitate the development of new muscarinic receptor subtype-selective ligands that could prove to be useful for the treatment of many severe pathophysiological conditions.
ESTHER : Kruse_2014_Nat.Rev.Drug.Discov_13_549
PubMedSearch : Kruse_2014_Nat.Rev.Drug.Discov_13_549
PubMedID: 24903776

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Citations formats

Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J (2014)
Muscarinic acetylcholine receptors: novel opportunities for drug development
Nat Rev Drug Discov 13 :549

Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J (2014)
Nat Rev Drug Discov 13 :549