Sexton PM

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Title : Molecular determinants of allosteric modulation at the m1 muscarinic acetylcholine receptor - Abdul-Ridha_2014_J.Biol.Chem_289_6067
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Title : Development of a photoactivatable allosteric ligand for the m1 muscarinic acetylcholine receptor - Davie_2014_ACS.Chem.Neurosci_5_902
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Title : Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M(1) muscarinic acetylcholine receptor - Keov_2013_Mol.Pharmacol_84_425
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Title : Activation and allosteric modulation of a muscarinic acetylcholine receptor - Kruse_2013_Nature_504_101
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Title : Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor - Mistry_2013_J.Med.Chem_56_5151
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Title : Allosteric modulation of a chemogenetically modified G protein-coupled receptor - Abdul-Ridha_2013_Mol.Pharmacol_83_521
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Title : Probing structural requirements of positive allosteric modulators of the m4 muscarinic receptor - Huynh_2013_J.Med.Chem_56_8196
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Title : Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor - Gregory_2012_J.Biol.Chem_287_37066
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Title : Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects - Valant_2012_Mol.Pharmacol_81_41
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Title : Structure-function studies of muscarinic acetylcholine receptors - Leach_2012_Handb.Exp.Pharmacol_208_29
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Title : The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor - Leach_2011_Mol.Pharmacol_79_855
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Title : Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms - Nawaratne_2010_J.Biol.Chem_285_19012
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Title : The effect of social isolation on rat brain expression of genes associated with endocannabinoid signaling - Robinson_2010_Brain.Res_1343_153
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Title : Detection of novel functional selectivity at M3 muscarinic acetylcholine receptors using a Saccharomyces cerevisiae platform - Stewart_2010_ACS.Chem.Biol_5_365
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Title : Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias - Gregory_2010_J.Biol.Chem_285_7459
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Title : Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae - Stewart_2010_Mol.Pharmacol_78_205
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Title : Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor - Avlani_2010_Mol.Pharmacol_78_94
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Title : Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties - Leach_2010_Neuropsychopharmacology_35_855
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Title : Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity - Stewart_2009_J.Pharmacol.Exp.Ther_331_277
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Title : New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug) - Nawaratne_2008_Mol.Pharmacol_74_1119
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Title : The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions - Avlani_2008_J.Pharmacol.Exp.Ther_325_927
Author(s) : Avlani VA , McLoughlin DJ , Sexton PM , Christopoulos A
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Title : A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric\/allosteric ligand - Valant_2008_J.Biol.Chem_283_29312
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Title : Allosteric modulation of muscarinic acetylcholine receptors - Gregory_2007_Curr.Neuropharmacol_5_157
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Title : Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors - May_2007_Mol.Pharmacol_72_463
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Ref : Molecular Pharmacology , 72 :463 , 2007
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Title : Involvement of the sigma1 (sigma1) receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX1-41 - Espallergues_2007_Br.J.Pharmacol_152_267
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Title : Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands - Avlani_2007_J.Biol.Chem_282_25677
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Title : Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors - Lanzafame_2006_Mol.Pharmacol_70_736
Author(s) : Lanzafame AA , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 70 :736 , 2006
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Title : Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators - May_2005_J.Pharmacol.Exp.Ther_312_382
Author(s) : May LT , Lin Y , Sexton PM , Christopoulos A
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Title : Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors - Avlani_2004_J.Pharmacol.Exp.Ther_308_1062
Author(s) : Avlani V , May LT , Sexton PM , Christopoulos A
Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :1062 , 2004
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Title : G-protein-coupled receptor allosterism: the promise and the problem(s) - Christopoulos_2004_Biochem.Soc.Trans_32_873
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Ref : Biochemical Society Transactions , 32 :873 , 2004
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