| Title : In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions - Kuca_2005_J.Appl.Toxicol_25_296 |
| Author(s) : Kuca K , Cabal J , Jun D , Kassa J , Bartosova L , Kunesova G |
| Ref : J Appl Toxicol , 25 :296 , 2005 |
|
Abstract :
In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and Hlo-7) for reactivation of sarin- and cyclosarin-inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin-inhibited AChE. On the other hand, only HI-6 is able to reactivate satisfactorily cyclosarin-inhibited AChE. |
| PubMedSearch : Kuca_2005_J.Appl.Toxicol_25_296 |
| PubMedID: 16025528 |
Kuca K, Cabal J, Jun D, Kassa J, Bartosova L, Kunesova G (2005)
In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions
J Appl Toxicol
25 :296
Kuca K, Cabal J, Jun D, Kassa J, Bartosova L, Kunesova G (2005)
J Appl Toxicol
25 :296