| Title : Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors - Lam_2012_Bioorg.Med.Chem.Lett_22_6628 |
| Author(s) : Lam B , Zhang Z , Stafford JA , Skene RJ , Shi L , Gwaltney SL, 2nd |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :6628 , 2012 |
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Abstract :
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors. |
| PubMedSearch : Lam_2012_Bioorg.Med.Chem.Lett_22_6628 |
| PubMedID: 23025999 |
| Gene_locus related to this paper: human-DPP4 |
| Inhibitor | CHEMBL2159182 |
| Gene_locus | human-DPP4 |
| Structure | 4G1F |
Lam B, Zhang Z, Stafford JA, Skene RJ, Shi L, Gwaltney SL, 2nd (2012)
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett
22 :6628
Lam B, Zhang Z, Stafford JA, Skene RJ, Shi L, Gwaltney SL, 2nd (2012)
Bioorganic & Medicinal Chemistry Lett
22 :6628