| Title : PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses - Lambrecht_1992_Eur.J.Pharmacol_217_217 |
| Author(s) : Lambrecht G , Friebe T , Grimm U , Windscheif U , Bungardt E , Hildebrandt C , Baumert HG , Spatz-Kumbel G , Mutschler E |
| Ref : European Journal of Pharmacology , 217 :217 , 1992 |
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Abstract :
We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha 1-adrenoceptors, muscarinic M2 and M3 receptors, histamine H1 and adenosine A1 receptors. Thus, PPADS is a novel and useful pharmacological tool to study co-transmission in tissues where ATP and co-existing neurotransmitters act in concert. |
| PubMedSearch : Lambrecht_1992_Eur.J.Pharmacol_217_217 |
| PubMedID: 1330591 |
Lambrecht G, Friebe T, Grimm U, Windscheif U, Bungardt E, Hildebrandt C, Baumert HG, Spatz-Kumbel G, Mutschler E (1992)
PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses
European Journal of Pharmacology
217 :217
Lambrecht G, Friebe T, Grimm U, Windscheif U, Bungardt E, Hildebrandt C, Baumert HG, Spatz-Kumbel G, Mutschler E (1992)
European Journal of Pharmacology
217 :217