Li_2011_Ann.Hum.Genet_75_605

Reference

Title : Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population - Li_2011_Ann.Hum.Genet_75_605
Author(s) : Li L , Qi L , Lv N , Gao Q , Cheng Y , Wei Y , Ye J , Yan X , Dang A
Ref : Ann Hum Genet , 75 :605 , 2011
Abstract :

The role of the lipoprotein-associated phospholipase A(2) gene (PLA2G7) in atherosclerosis remains controversial. We investigated the frequency of single-nucleotide polymorphisms (SNPs) of PLA2G7 (rs16874954 and rs1051931) and their association with coronary artery disease (CAD) in a cohort of CAD patients (n= 806) and age-matched healthy controls (n= 482) in the Chinese Han population. The VF and FF genotype of rs16874954 was significantly more frequent in the CAD patients (13.5%) than in the controls (9.3%, P= 0.024). The association remained after adjustment for age, gender, body mass index, smoking status, history of diabetes, positive family history of CAD, high-density lipoprotein cholesterol, and triglyceride (OR = 1.922; 95% CI [1.146-3.224]; P= 0.013). There was no significant difference in the frequency of any genotype of rs1051931 between the two groups. However, the frequency of the allele V379 was significantly greater in CAD patients with a history of myocardial infarction (MI) than in those without a history of MI (18.7% and 14.8%, P= 0.038). We conclude that there is significant association between the rs16874954 mutation and CAD in the Chinese Han population. The expression of rs1051931 variant in CAD patients may entail increased risk of MI.

PubMedSearch : Li_2011_Ann.Hum.Genet_75_605
PubMedID: 21834908
Gene_locus related to this paper: human-PLA2G7

Citations formats

Li L, Qi L, Lv N, Gao Q, Cheng Y, Wei Y, Ye J, Yan X, Dang A (2011)
Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population
Ann Hum Genet 75 :605

Li L, Qi L, Lv N, Gao Q, Cheng Y, Wei Y, Ye J, Yan X, Dang A (2011)
Ann Hum Genet 75 :605