Title : Efficient synthesis of cyano-containing multi-substituted indoles catalyzed by lipase - Li_2020_Bioorg.Chem_107_104583 |
Author(s) : Li F , Xu Y , Wang C , Zhao R , Wang L |
Ref : Bioorg Chem , 107 :104583 , 2020 |
Abstract :
BACKGROUND: Indoles are important bioactive compounds that have been extensively studied in organic chemistry. In this work, a green and efficient process for the synthesis of Indoles from 1,3-diketones with fumaronitrile was developed. RESULTS: Under optimal conditions (1,3-diketones (0.5 mmol), fumaronitrile (1 mmol), water (2 ml), lipase (15 mg), 30 degreesC, 24 h), high yields and satisfactory regioselectivity of cyano-containing multi-substituted indoles could be obtained when CRL (C. rugosa lipase) was used as the catalyst. CONCLUSION: This enzymatic method demonstrates the great potential for the synthesis of indoles and extends the application of enzyme in organic synthesis. |
PubMedSearch : Li_2020_Bioorg.Chem_107_104583 |
PubMedID: 33421956 |
Li F, Xu Y, Wang C, Zhao R, Wang L (2020)
Efficient synthesis of cyano-containing multi-substituted indoles catalyzed by lipase
Bioorg Chem
107 :104583
Li F, Xu Y, Wang C, Zhao R, Wang L (2020)
Bioorg Chem
107 :104583