| Title : (-)-Grandiflorimine, a new dibenzopyrrocoline alkaloid with cholinesterase inhibitory activity from Illigera grandiflora - Li_2021_Nat.Prod.Res_35_763 |
| Author(s) : Li X , Dong J , Gan D , Zhou D , Cai X , Cai L , Ding Z |
| Ref : Nat Prod Res , 35 :763 , 2021 |
|
Abstract :
A new dibenzopyrrocoline alkaloid, (-)-grandifloramine (1), together with five known ones, actinodaphnine (2), N-methyllaurotetanine (3), boldine (4), lindcarpine (5), and (+)-norboldine (6), were isolated from Illigera grandiflora W. W. Sm. et J. F. Jeff. The structure of 1 was identified by HRESIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 and 2 exhibited the moderate inhibitory activity against acetylcholinesterase and 3 showed moderate butyrylcholinesterase inhibitory activity. This is the first report of the chemical constituents of I. grandiflora. |
| PubMedSearch : Li_2021_Nat.Prod.Res_35_763 |
| PubMedID: 31079474 |
Li X, Dong J, Gan D, Zhou D, Cai X, Cai L, Ding Z (2021)
(-)-Grandiflorimine, a new dibenzopyrrocoline alkaloid with cholinesterase inhibitory activity from Illigera grandiflora
Nat Prod Res
35 :763
Li X, Dong J, Gan D, Zhou D, Cai X, Cai L, Ding Z (2021)
Nat Prod Res
35 :763