Fumonisin-B1
Fumonisins are toxins produced by several species of Fusarium molds, such as Fusarium verticillioides which occur mainly in maize (corn), wheat and other cereals. Fumonisin B1 is hepatotoxic and nephrotoxic. fumonisins are able to inhibit sphingosine-sphinganin-transferases and ceramide synthases and are therefore competitive inhibitors of sphingolipid biosynthesis and metabolism. Fumonisin is hydrolysed by Sphingopyxis macrogoltabida FumD. It is used as enzyme-based feed additive intended to degrade fumonisin mycotoxins found as contaminants in feeds for growing pigs
General
Type : Mycotoxin-metabolite, Natural, Toxin
Chemical_Nomenclature : 2-[2-[19-amino-6-(3,4-dicarboxybutanoyloxy)-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid
Canonical SMILES : CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
InChI : InChI=1S\/C34H59NO15\/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35\/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)
InChIKey : UVBUBMSSQKOIBE-UHFFFAOYSA-N
Other name(s) : Fumonisin b1 || Macrofusine || Fusarium moniliforme || NSC629151 || FB1 || CHEBI:38221 || CHEMBL5282242 || SCHEMBL13555629
MW : 721.82
Formula : C34H59NO15
CAS_number : 116355-83-0
UniChem : UVBUBMSSQKOIBE-UHFFFAOYSA-N
Wikipedia : Fumonisin_B1
Target
Structures : No structure
Families : Carb_B_Bacteria
References (33)
| Title : Understanding the molecular mechanism of fumonisin esterases by kinetic and structural studies - Incze_2025_Food.Chem_473_143110 |
| Author(s) : Incze DJ , Molnar Z , Nagy GN , Leveles I , Vertessy BG , Poppe L , Bata Z |
| Ref : Food Chem , 473 :143110 , 2025 |
| Abstract : |
| PubMedSearch : Incze_2025_Food.Chem_473_143110 |
| PubMedID: 39892340 |
| Gene_locus related to this paper: sphmc-FumD , uncxx-CFE |
| Title : Understanding the molecular mechanism of fumonisin esterases by kinetic and structural studies - Incze_2025_Food.Chem_473_143110 |
| Author(s) : Incze DJ , Molnar Z , Nagy GN , Leveles I , Vertessy BG , Poppe L , Bata Z |
| Ref : Food Chem , 473 :143110 , 2025 |
| Abstract : |
| PubMedSearch : Incze_2025_Food.Chem_473_143110 |
| PubMedID: 39892340 |
| Gene_locus related to this paper: sphmc-FumD , uncxx-CFE |
| Title : Understanding the molecular mechanism of fumonisin esterases by kinetic and structural studies - Incze_2025_Food.Chem_473_143110 |
| Author(s) : Incze DJ , Molnar Z , Nagy GN , Leveles I , Vertessy BG , Poppe L , Bata Z |
| Ref : Food Chem , 473 :143110 , 2025 |
| Abstract : |
| PubMedSearch : Incze_2025_Food.Chem_473_143110 |
| PubMedID: 39892340 |
| Gene_locus related to this paper: sphmc-FumD , uncxx-CFE |
| Title : Comparison Study of Two Fumonisin-Degrading Enzymes for Detoxification in Piglets - Wang_2024_Toxins.(Basel)_16_3 |
| Author(s) : Wang Z , Lv Z , Czabany T , Nagl V , Krska R , Wang X , Han B , Tao H , Liu J , Wang J |
| Ref : Toxins (Basel) , 16 :3 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Toxins.(Basel)_16_3 |
| PubMedID: 38276527 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : Comparison Study of Two Fumonisin-Degrading Enzymes for Detoxification in Piglets - Wang_2024_Toxins.(Basel)_16_3 |
| Author(s) : Wang Z , Lv Z , Czabany T , Nagl V , Krska R , Wang X , Han B , Tao H , Liu J , Wang J |
| Ref : Toxins (Basel) , 16 :3 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Toxins.(Basel)_16_3 |
| PubMedID: 38276527 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : Comparison Study of Two Fumonisin-Degrading Enzymes for Detoxification in Piglets - Wang_2024_Toxins.(Basel)_16_3 |
| Author(s) : Wang Z , Lv Z , Czabany T , Nagl V , Krska R , Wang X , Han B , Tao H , Liu J , Wang J |
| Ref : Toxins (Basel) , 16 :3 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Toxins.(Basel)_16_3 |
| PubMedID: 38276527 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : Optimization Workflow of Fumonisin Esterase Production for Biocatalytic Degradation of Fumonisin B(1) - Incze_2023_Life.(Basel)_13_1885 |
| Author(s) : Incze DJ , Poppe L , Bata Z |
| Ref : Life (Basel) , 13 : , 2023 |
| Abstract : |
| PubMedSearch : Incze_2023_Life.(Basel)_13_1885 |
| PubMedID: 37763289 |
| Gene_locus related to this paper: sphmc-FumD , uncxx-CFE |
| Title : Optimization Workflow of Fumonisin Esterase Production for Biocatalytic Degradation of Fumonisin B(1) - Incze_2023_Life.(Basel)_13_1885 |
| Author(s) : Incze DJ , Poppe L , Bata Z |
| Ref : Life (Basel) , 13 : , 2023 |
| Abstract : |
| PubMedSearch : Incze_2023_Life.(Basel)_13_1885 |
| PubMedID: 37763289 |
| Gene_locus related to this paper: sphmc-FumD , uncxx-CFE |
| Title : Optimization Workflow of Fumonisin Esterase Production for Biocatalytic Degradation of Fumonisin B(1) - Incze_2023_Life.(Basel)_13_1885 |
| Author(s) : Incze DJ , Poppe L , Bata Z |
| Ref : Life (Basel) , 13 : , 2023 |
| Abstract : |
| PubMedSearch : Incze_2023_Life.(Basel)_13_1885 |
| PubMedID: 37763289 |
| Gene_locus related to this paper: sphmc-FumD , uncxx-CFE |
| Title : Biodegradation of Fumonisins by the Consecutive Action of a Fusion Enzyme - Li_2022_Toxins.(Basel)_14_ |
| Author(s) : Li K , Yu S , Yu D , Lin H , Liu N , Wu A |
| Ref : Toxins (Basel) , 14 : , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_Toxins.(Basel)_14_ |
| PubMedID: 35448875 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs - Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| Author(s) : Liu Q , Huang L , Cui Z , Qiao B , Li F , Wang C |
| Ref : Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess , :1 , 2022 |
| Abstract : |
| PubMedSearch : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedID: 35858108 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : Biodegradation of Fumonisins by the Consecutive Action of a Fusion Enzyme - Li_2022_Toxins.(Basel)_14_ |
| Author(s) : Li K , Yu S , Yu D , Lin H , Liu N , Wu A |
| Ref : Toxins (Basel) , 14 : , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_Toxins.(Basel)_14_ |
| PubMedID: 35448875 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs - Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| Author(s) : Liu Q , Huang L , Cui Z , Qiao B , Li F , Wang C |
| Ref : Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess , :1 , 2022 |
| Abstract : |
| PubMedSearch : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedID: 35858108 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : Biodegradation of Fumonisins by the Consecutive Action of a Fusion Enzyme - Li_2022_Toxins.(Basel)_14_ |
| Author(s) : Li K , Yu S , Yu D , Lin H , Liu N , Wu A |
| Ref : Toxins (Basel) , 14 : , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_Toxins.(Basel)_14_ |
| PubMedID: 35448875 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs - Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| Author(s) : Liu Q , Huang L , Cui Z , Qiao B , Li F , Wang C |
| Ref : Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess , :1 , 2022 |
| Abstract : |
| PubMedSearch : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedID: 35858108 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : FumDSB Can Reduce the Toxic Effects of Fumonisin B(1) by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs - Liu_2021_Toxins.(Basel)_13_874 |
| Author(s) : Liu Q , Li F , Huang L , Chen W , Li Z , Wang C |
| Ref : Toxins (Basel) , 13 :874 , 2021 |
| Abstract : |
| PubMedSearch : Liu_2021_Toxins.(Basel)_13_874 |
| PubMedID: 34941712 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |
| Title : Biological detoxification of fumonisin by a novel carboxylesterase from Sphingomonadales bacterium and its biochemical characterization - Li_2021_Int.J.Biol.Macromol_169_18 |
| Author(s) : Li Z , Wang Y , Liu Z , Jin S , Pan K , Liu H , Liu T , Li X , Zhang C , Luo X , Song Y , Zhao J , Zhang T |
| Ref : Int J Biol Macromol , 169 :18 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Int.J.Biol.Macromol_169_18 |
| PubMedID: 33309671 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |
| Title : The efficacy and effect on gut microbiota of an aflatoxin binder and a fumonisin esterase using an in vitro simulator of the human intestinal microbial ecosystem (SHIME) - Neckermann_2021_Food.Res.Int_145_110395 |
| Author(s) : Neckermann K , Claus G , De Baere S , Antonissen G , Lebrun S , Gemmi C , Taminiau B , Douny C , Scippo ML , Schatzmayr D , Gathumbi J , Uhlig S , Croubels S , Delcenserie V |
| Ref : Food Res Int , 145 :110395 , 2021 |
| Abstract : |
| PubMedSearch : Neckermann_2021_Food.Res.Int_145_110395 |
| PubMedID: 34112398 |
| Title : FumDSB Can Reduce the Toxic Effects of Fumonisin B(1) by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs - Liu_2021_Toxins.(Basel)_13_874 |
| Author(s) : Liu Q , Li F , Huang L , Chen W , Li Z , Wang C |
| Ref : Toxins (Basel) , 13 :874 , 2021 |
| Abstract : |
| PubMedSearch : Liu_2021_Toxins.(Basel)_13_874 |
| PubMedID: 34941712 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |
| Title : Biological detoxification of fumonisin by a novel carboxylesterase from Sphingomonadales bacterium and its biochemical characterization - Li_2021_Int.J.Biol.Macromol_169_18 |
| Author(s) : Li Z , Wang Y , Liu Z , Jin S , Pan K , Liu H , Liu T , Li X , Zhang C , Luo X , Song Y , Zhao J , Zhang T |
| Ref : Int J Biol Macromol , 169 :18 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Int.J.Biol.Macromol_169_18 |
| PubMedID: 33309671 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |
| Title : The efficacy and effect on gut microbiota of an aflatoxin binder and a fumonisin esterase using an in vitro simulator of the human intestinal microbial ecosystem (SHIME) - Neckermann_2021_Food.Res.Int_145_110395 |
| Author(s) : Neckermann K , Claus G , De Baere S , Antonissen G , Lebrun S , Gemmi C , Taminiau B , Douny C , Scippo ML , Schatzmayr D , Gathumbi J , Uhlig S , Croubels S , Delcenserie V |
| Ref : Food Res Int , 145 :110395 , 2021 |
| Abstract : |
| PubMedSearch : Neckermann_2021_Food.Res.Int_145_110395 |
| PubMedID: 34112398 |
| Title : The efficacy and effect on gut microbiota of an aflatoxin binder and a fumonisin esterase using an in vitro simulator of the human intestinal microbial ecosystem (SHIME) - Neckermann_2021_Food.Res.Int_145_110395 |
| Author(s) : Neckermann K , Claus G , De Baere S , Antonissen G , Lebrun S , Gemmi C , Taminiau B , Douny C , Scippo ML , Schatzmayr D , Gathumbi J , Uhlig S , Croubels S , Delcenserie V |
| Ref : Food Res Int , 145 :110395 , 2021 |
| Abstract : |
| PubMedSearch : Neckermann_2021_Food.Res.Int_145_110395 |
| PubMedID: 34112398 |
| Title : FumDSB Can Reduce the Toxic Effects of Fumonisin B(1) by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs - Liu_2021_Toxins.(Basel)_13_874 |
| Author(s) : Liu Q , Li F , Huang L , Chen W , Li Z , Wang C |
| Ref : Toxins (Basel) , 13 :874 , 2021 |
| Abstract : |
| PubMedSearch : Liu_2021_Toxins.(Basel)_13_874 |
| PubMedID: 34941712 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |
| Title : Biological detoxification of fumonisin by a novel carboxylesterase from Sphingomonadales bacterium and its biochemical characterization - Li_2021_Int.J.Biol.Macromol_169_18 |
| Author(s) : Li Z , Wang Y , Liu Z , Jin S , Pan K , Liu H , Liu T , Li X , Zhang C , Luo X , Song Y , Zhao J , Zhang T |
| Ref : Int J Biol Macromol , 169 :18 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Int.J.Biol.Macromol_169_18 |
| PubMedID: 33309671 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |
| Title : Detoxification of the Fumonisin Mycotoxins in Maize: An Enzymatic Approach - Alberts_2019_Toxins.(Basel)_11_523 |
| Author(s) : Alberts J , Schatzmayr G , Moll WD , Davids I , Rheeder J , Burger HM , Shephard G , Gelderblom W |
| Ref : Toxins (Basel) , 11 : , 2019 |
| Abstract : |
| PubMedSearch : Alberts_2019_Toxins.(Basel)_11_523 |
| PubMedID: 31510008 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Detoxification of the Fumonisin Mycotoxins in Maize: An Enzymatic Approach - Alberts_2019_Toxins.(Basel)_11_523 |
| Author(s) : Alberts J , Schatzmayr G , Moll WD , Davids I , Rheeder J , Burger HM , Shephard G , Gelderblom W |
| Ref : Toxins (Basel) , 11 : , 2019 |
| Abstract : |
| PubMedSearch : Alberts_2019_Toxins.(Basel)_11_523 |
| PubMedID: 31510008 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Detoxification of the Fumonisin Mycotoxins in Maize: An Enzymatic Approach - Alberts_2019_Toxins.(Basel)_11_523 |
| Author(s) : Alberts J , Schatzmayr G , Moll WD , Davids I , Rheeder J , Burger HM , Shephard G , Gelderblom W |
| Ref : Toxins (Basel) , 11 : , 2019 |
| Abstract : |
| PubMedSearch : Alberts_2019_Toxins.(Basel)_11_523 |
| PubMedID: 31510008 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Gastrointestinal Degradation of Fumonisin B(1) by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine - Masching_2016_Toxins.(Basel)_8_ |
| Author(s) : Masching S , Naehrer K , Schwartz-Zimmermann HE , Sarandan M , Schaumberger S , Dohnal I , Nagl V , Schatzmayr D |
| Ref : Toxins (Basel) , 8 : , 2016 |
| Abstract : |
| PubMedSearch : Masching_2016_Toxins.(Basel)_8_ |
| PubMedID: 27007395 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Gastrointestinal Degradation of Fumonisin B(1) by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine - Masching_2016_Toxins.(Basel)_8_ |
| Author(s) : Masching S , Naehrer K , Schwartz-Zimmermann HE , Sarandan M , Schaumberger S , Dohnal I , Nagl V , Schatzmayr D |
| Ref : Toxins (Basel) , 8 : , 2016 |
| Abstract : |
| PubMedSearch : Masching_2016_Toxins.(Basel)_8_ |
| PubMedID: 27007395 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Gastrointestinal Degradation of Fumonisin B(1) by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine - Masching_2016_Toxins.(Basel)_8_ |
| Author(s) : Masching S , Naehrer K , Schwartz-Zimmermann HE , Sarandan M , Schaumberger S , Dohnal I , Nagl V , Schatzmayr D |
| Ref : Toxins (Basel) , 8 : , 2016 |
| Abstract : |
| PubMedSearch : Masching_2016_Toxins.(Basel)_8_ |
| PubMedID: 27007395 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes - Heinl_2010_J.Biotechnol_145_120 |
| Author(s) : Heinl S , Hartinger D , Thamhesl M , Vekiru E , Krska R , Schatzmayr G , Moll WD , Grabherr R |
| Ref : J Biotechnol , 145 :120 , 2010 |
| Abstract : |
| PubMedSearch : Heinl_2010_J.Biotechnol_145_120 |
| PubMedID: 19922747 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes - Heinl_2010_J.Biotechnol_145_120 |
| Author(s) : Heinl S , Hartinger D , Thamhesl M , Vekiru E , Krska R , Schatzmayr G , Moll WD , Grabherr R |
| Ref : J Biotechnol , 145 :120 , 2010 |
| Abstract : |
| PubMedSearch : Heinl_2010_J.Biotechnol_145_120 |
| PubMedID: 19922747 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes - Heinl_2010_J.Biotechnol_145_120 |
| Author(s) : Heinl S , Hartinger D , Thamhesl M , Vekiru E , Krska R , Schatzmayr G , Moll WD , Grabherr R |
| Ref : J Biotechnol , 145 :120 , 2010 |
| Abstract : |
| PubMedSearch : Heinl_2010_J.Biotechnol_145_120 |
| PubMedID: 19922747 |
| Gene_locus related to this paper: sphmc-FumD |