| Title : A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity - Magrioti_2008_Bioorg.Med.Chem.Lett_18_5424 |
| Author(s) : Magrioti V , Naxakis G , Hadjipavlou-Litina D , Makriyannis A , Kokotos G |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5424 , 2008 |
|
Abstract :
A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K(i) 21.8 microM) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain. |
| PubMedSearch : Magrioti_2008_Bioorg.Med.Chem.Lett_18_5424 |
| PubMedID: 18819796 |
Magrioti V, Naxakis G, Hadjipavlou-Litina D, Makriyannis A, Kokotos G (2008)
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity
Bioorganic & Medicinal Chemistry Lett
18 :5424
Magrioti V, Naxakis G, Hadjipavlou-Litina D, Makriyannis A, Kokotos G (2008)
Bioorganic & Medicinal Chemistry Lett
18 :5424