Makriyannis A

References (40)

Title : P2X(7) receptor-dependent increase in endocannabinoid 2-arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism - Singh_2024_Br.J.Pharmacol__
Author(s) : Singh S , Sarroza D , English A , Whittington D , Dong A , Malamas M , Makriyannis A , van der Stelt M , Li Y , Zweifel L , Bruchas MR , Land BB , Stella N
Ref : British Journal of Pharmacology , : , 2024
PubMedID: 38581262

Title : Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase - Benchama_2022_Sci.Rep_12_5328
Author(s) : Benchama O , Tyukhtenko S , Malamas MS , Williams MK , Makriyannis A , Avraham HK
Ref : Sci Rep , 12 :5328 , 2022
PubMedID: 35351947
Gene_locus related to this paper: human-MGLL

Title : Untapped endocannabinoid pharmacological targets: pipe dream or pipeline? - Wilkerson_2021_Pharmacol.Biochem.Behav__173192
Author(s) : Wilkerson JL , Bilbrey JA , Felix JS , Makriyannis A , McMahon LR
Ref : Pharmacol Biochem Behav , :173192 , 2021
PubMedID: 33932409

Title : The endocannabinoid 2-arachidonoylglycerol and dual ABHD6\/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity - Kokona_2021_Neuropharmacol_185_108450
Author(s) : Kokona D , Spyridakos D , Tzatzarakis M , Papadogkonaki S , Filidou E , Arvanitidis KI , Kolios G , Lamani M , Makriyannis A , Malamas MS , Thermos K
Ref : Neuropharmacology , 185 :108450 , 2021
PubMedID: 33450278
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors - Malamas_2021_ChemMedChem__
Author(s) : Malamas MS , Lamani M , Farah SI , Mohammad KA , Miyabe CY , Rajarshi G , Wu S , Zvonok N , Chandrashekhar H , Wood J , Makriyannis A
Ref : ChemMedChem , : , 2021
PubMedID: 34486233
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1 - Farah_2021_Biochem.Biophys.Res.Commun_591_31
Author(s) : Farah SI , Hilston S , Tran N , Zvonok N , Makriyannis A
Ref : Biochemical & Biophysical Research Communications , 591 :31 , 2021
PubMedID: 34995983
Gene_locus related to this paper: human-ABHD6 , human-MGLL

Title : Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors - Malamas_2020_Bioorg.Med.Chem_28_115195
Author(s) : Malamas MS , Farah SI , Lamani M , Pelekoudas DN , Perry NT , Rajarshi G , Miyabe CY , Chandrashekhar H , West J , Pavlopoulos S , Makriyannis A
Ref : Bioorganic & Medicinal Chemistry , 28 :115195 , 2020
PubMedID: 31761726

Title : Conformational gating, dynamics and allostery in human monoacylglycerol lipase - Tyukhtenko_2020_Sci.Rep_10_18531
Author(s) : Tyukhtenko S , Ma X , Rajarshi G , Karageorgos I , Anderson KW , Hudgens JW , Guo JJ , Nasr ML , Zvonok N , Vemuri K , Wagner G , Makriyannis A
Ref : Sci Rep , 10 :18531 , 2020
PubMedID: 33116203
Gene_locus related to this paper: human-MGLL

Title : Biochemical and Proteomic Characterization of Recombinant Human alpha\/beta Hydrolase Domain 6 - Shields_2019_Sci.Rep_9_890
Author(s) : Shields CM , Zvonok N , Zvonok A , Makriyannis A
Ref : Sci Rep , 9 :890 , 2019
PubMedID: 30696836
Gene_locus related to this paper: human-ABHD6

Title : Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment - Alapafuja_2019_Bioorg.Med.Chem_27_55
Author(s) : Alapafuja SO , Malamas MS , Shukla V , Zvonok A , Miller S , Daily L , Rajarshi G , Miyabe CY , Chandrashekhar H , Wood J , Tyukhtenko S , Straiker A , Makriyannis A
Ref : Bioorganic & Medicinal Chemistry , 27 :55 , 2019
PubMedID: 30446439

Title : Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats - Sticht_2019_Br.J.Pharmacol_176_1524
Author(s) : Sticht MA , Lau DJ , Keenan CM , Cavin JB , Morena M , Vemuri VK , Makriyannis A , Cravatt BF , Sharkey KA , Hill MN
Ref : British Journal of Pharmacology , 176 :1524 , 2019
PubMedID: 30051485

Title : Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology - Lamani_2019_Bioorg.Med.Chem_27_115096
Author(s) : Lamani M , Malamas MS , Farah SI , Shukla VG , Almeida MF , Weerts CM , Anderson J , Wood JT , Farizatto KLG , Bahr BA , Makriyannis A
Ref : Bioorganic & Medicinal Chemistry , 27 :115096 , 2019
PubMedID: 31629610

Title : ( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes - Liu_2018_J.Med.Chem_61_8639
Author(s) : Liu Y , Ji L , Eno M , Kudalkar S , Li AL , Schimpgen M , Benchama O , Morales P , Xu S , Hurst D , Wu S , Mohammad KA , Wood JT , Zvonok N , Papahatjis DP , Zhou H , Honrao C , Mackie K , Reggio P , Hohmann AG , Marnett LJ , Makriyannis A , Nikas SP
Ref : Journal of Medicinal Chemistry , 61 :8639 , 2018
PubMedID: 30196704

Title : Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase - Tyukhtenko_2018_Sci.Rep_8_1719
Author(s) : Tyukhtenko S , Rajarshi G , Karageorgos I , Zvonok N , Gallagher ES , Huang H , Vemuri K , Hudgens JW , Ma X , Nasr ML , Pavlopoulos S , Makriyannis A
Ref : Sci Rep , 8 :1719 , 2018
PubMedID: 29379013
Gene_locus related to this paper: human-MGLL

Title : The role of human monoacylglycerol lipase (hMAGL) binding pocket in breakup of unsaturated phospholipid membranes - Karageorgos_2017_Anal.Biochem_536_90
Author(s) : Karageorgos I , Silin VI , Zvonok N , Marino J , Janero DR , Makriyannis A
Ref : Analytical Biochemistry , 536 :90 , 2017
PubMedID: 28822686
Gene_locus related to this paper: human-MGLL

Title : Cannabinoid CB(1) Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors - Leonard_2017_J.Pharmacol.Exp.Ther_363_314
Author(s) : Leonard MZ , Alapafuja SO , Ji L , Shukla VG , Liu Y , Nikas SP , Makriyannis A , Bergman J , Kangas BD
Ref : Journal of Pharmacology & Experimental Therapeutics , 363 :314 , 2017
PubMedID: 28947487

Title : Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGES - Tyukhtenko_2016_J.Biol.Chem_291_2556
Author(s) : Tyukhtenko S , Karageorgos I , Rajarshi G , Zvonok N , Pavlopoulos S , Janero DR , Makriyannis A
Ref : Journal of Biological Chemistry , 291 :2556 , 2016
PubMedID: 26555264

Title : Endocannabinoid Signaling Regulates Sleep Stability - Pava_2016_PLoS.One_11_e0152473
Author(s) : Pava MJ , Makriyannis A , Lovinger DM
Ref : PLoS ONE , 11 :e0152473 , 2016
PubMedID: 27031992

Title : Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats - Panlilio_2016_Psychopharmacology.(Berl)_233_1879
Author(s) : Panlilio LV , Thorndike EB , Nikas SP , Alapafuja SO , Bandiera T , Cravatt BF , Makriyannis A , Piomelli D , Goldberg SR , Justinova Z
Ref : Psychopharmacology (Berl) , 233 :1879 , 2016
PubMedID: 26558620

Title : Medicinal chemistry of cannabinoids - Vemuri_2015_Clin.Pharmacol.Ther_97_553
Author(s) : Vemuri VK , Makriyannis A
Ref : Clinical Pharmacology & Therapeutics , 97 :553 , 2015
PubMedID: 25801236

Title : Translational strategies for therapeutic development in nicotine addiction: rethinking the conventional bench to bedside approach - Le Foll_2014_Prog.Neuropsychopharmacol.Biol.Psychiatry_52_86
Author(s) : Le Foll B , Pushparaj A , Pryslawsky Y , Forget B , Vemuri K , Makriyannis A , Trigo JM
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 52 :86 , 2014
PubMedID: 24140878

Title : Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors - Nader_2014_Neuropharmacol_87_214
Author(s) : Nader J , Rapino C , Gennequin B , Chavant F , Francheteau M , Makriyannis A , Duranti A , Maccarrone M , Solinas M , Thiriet N
Ref : Neuropharmacology , 87 :214 , 2014
PubMedID: 24709540

Title : Analysis of tolerance and behavioral\/physical dependence during chronic CB1 agonist treatment: effects of CB1 agonists, antagonists, and noncannabinoid drugs - Desai_2013_J.Pharmacol.Exp.Ther_344_319
Author(s) : Desai RI , Thakur GA , Vemuri VK , Bajaj S , Makriyannis A , Bergman J
Ref : Journal of Pharmacology & Experimental Therapeutics , 344 :319 , 2013
PubMedID: 23197773

Title : Highly predictive ligand-based pharmacophore and homology models of ABHD6 - Bowman_2013_Chem.Biol.Drug.Des_81_382
Author(s) : Bowman AL , Makriyannis A
Ref : Chemical Biology Drug Des , 81 :382 , 2013
PubMedID: 23110439
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Novel adamantyl cannabinoids as CB1 receptor probes - Thakur_2013_J.Med.Chem_56_3904
Author(s) : Thakur GA , Bajaj S , Paronis C , Peng Y , Bowman AL , Barak LS , Caron MG , Parrish D , Deschamps JR , Makriyannis A
Ref : Journal of Medicinal Chemistry , 56 :3904 , 2013
PubMedID: 23621789

Title : Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study - Karageorgos_2013_Biochemistry_52_5016
Author(s) : Karageorgos I , Wales TE , Janero DR , Zvonok N , Vemuri VK , Engen JR , Makriyannis A
Ref : Biochemistry , 52 :5016 , 2013
PubMedID: 23795559

Title : Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire - Nasr_2013_Protein.Sci_22_774
Author(s) : Nasr ML , Shi X , Bowman AL , Johnson M , Zvonok N , Janero DR , Vemuri VK , Wales TE , Engen JR , Makriyannis A
Ref : Protein Science , 22 :774 , 2013
PubMedID: 23553709

Title : Assay and inhibition of diacylglycerol lipase activity - Johnston_2012_Bioorg.Med.Chem.Lett_22_4585
Author(s) : Johnston M , Bhatt SR , Sikka S , Mercier RW , West JM , Makriyannis A , Gatley SJ , Duclos RI, Jr.
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :4585 , 2012
PubMedID: 22738638

Title : Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology - Naidoo_2012_Neurotherapeutics_9_801
Author(s) : Naidoo V , Karanian DA , Vadivel SK , Locklear JR , Wood JT , Nasr M , Quizon PM , Graves EE , Shukla V , Makriyannis A , Bahr BA
Ref : Neurotherapeutics , 9 :801 , 2012
PubMedID: 22270809

Title : Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL) - Karageorgos_2012_ACS.Chem.Neurosci_3_393
Author(s) : Karageorgos I , Zvonok N , Janero DR , Vemuri VK , Shukla V , Wales TE , Engen JR , Makriyannis A
Ref : ACS Chem Neurosci , 3 :393 , 2012
PubMedID: 22860208
Gene_locus related to this paper: human-MGLL

Title : Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism - Karageorgos_2010_Mol.Biosyst_6_1381
Author(s) : Karageorgos I , Tyukhtenko S , Zvonok N , Janero DR , Sallum C , Makriyannis A
Ref : Mol Biosyst , 6 :1381 , 2010
PubMedID: 20464001

Title : Refined homology model of monoacylglycerol lipase: toward a selective inhibitor - Bowman_2009_J.Comput.Aided.Mol.Des_23_799
Author(s) : Bowman AL , Makriyannis A
Ref : J Comput Aided Mol Des , 23 :799 , 2009
PubMedID: 19543978

Title : A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity - Magrioti_2008_Bioorg.Med.Chem.Lett_18_5424
Author(s) : Magrioti V , Naxakis G , Hadjipavlou-Litina D , Makriyannis A , Kokotos G
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5424 , 2008
PubMedID: 18819796

Title : Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification - Zvonok_2008_J.Proteome.Res_7_2158
Author(s) : Zvonok N , Williams J , Johnston M , Pandarinathan L , Janero DR , Li J , Krishnan SC , Makriyannis A
Ref : J Proteome Res , 7 :2158 , 2008
PubMedID: 18452279

Title : The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats - Sink_2008_Neuropsychopharmacology_33_946
Author(s) : Sink KS , McLaughlin PJ , Wood JA , Brown C , Fan P , Vemuri VK , Peng Y , Olszewska T , Thakur GA , Makriyannis A , Parker LA , Salamone JD
Ref : Neuropsychopharmacology , 33 :946 , 2008
PubMedID: 17581535

Title : Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis - Zvonok_2008_Chem.Biol_15_854
Author(s) : Zvonok N , Pandarinathan L , Williams J , Johnston M , Karageorgos I , Janero DR , Krishnan SC , Makriyannis A
Ref : Chemical Biology , 15 :854 , 2008
PubMedID: 18721756

Title : Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity - Khanolkar_2007_J.Med.Chem_50_6493
Author(s) : Khanolkar AD , Lu D , Ibrahim M , Duclos RI, Jr. , Thakur GA , Malan TP, Jr. , Porreca F , Veerappan V , Tian X , George C , Parrish DA , Papahatjis DP , Makriyannis A
Ref : Journal of Medicinal Chemistry , 50 :6493 , 2007
PubMedID: 18038967

Title : Targeting the endocannabinoid system in treating brain disorders - Bahr_2006_Expert.Opin.Investig.Drugs_15_351
Author(s) : Bahr BA , Karanian DA , Makanji SS , Makriyannis A
Ref : Expert Opin Investig Drugs , 15 :351 , 2006
PubMedID: 16548785

Title : Adamantyl cannabinoids: a novel class of cannabinergic ligands - Lu_2005_J.Med.Chem_48_4576
Author(s) : Lu D , Meng Z , Thakur GA , Fan P , Steed J , Tartal CL , Hurst DP , Reggio PH , Deschamps JR , Parrish DA , George C , Jarbe TU , Lamb RJ , Makriyannis A
Ref : Journal of Medicinal Chemistry , 48 :4576 , 2005
PubMedID: 15999995

Title : The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats - McLaughlin_2005_Behav.Pharmacol_16_477
Author(s) : McLaughlin PJ , Brown CM , Winston KM , Thakur G , Lu D , Makriyannis A , Salamone JD
Ref : Behav Pharmacol , 16 :477 , 2005
PubMedID: 16148454