| Title : Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors - Moon_2000_Bioorg.Med.Chem.Lett_10_1435 |
| Author(s) : Moon SC , Shin JH , Jeong BH , Kim HS , Yu BS , Lee JS , Lee BS , Namgoong SK |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :1435 , 2000 |
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Abstract :
New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2-4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with Ki values of microM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities. |
| PubMedSearch : Moon_2000_Bioorg.Med.Chem.Lett_10_1435 |
| PubMedID: 10888326 |
Moon SC, Shin JH, Jeong BH, Kim HS, Yu BS, Lee JS, Lee BS, Namgoong SK (2000)
Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett
10 :1435
Moon SC, Shin JH, Jeong BH, Kim HS, Yu BS, Lee JS, Lee BS, Namgoong SK (2000)
Bioorganic & Medicinal Chemistry Lett
10 :1435