| Title : Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors - Padnya_2019_Bioorg.Chem__103455 |
| Author(s) : Padnya PL , Bayarashov EE , Zueva IV , Lushchekina SV , Lenina OA , Evtugyn VG , Osin YN , Petrov KA , Stoikov, II |
| Ref : Bioorg Chem , :103455 , 2019 |
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Abstract :
Novel ammonium and betaine derivatives of p-tert-butylthiacalix[4]arene in cone and 1,3-alternate conformation were synthesized with high yields for the first time. The obtained compounds form in water spherical nanoparticles. It was shown by molecular docking calculations and in vitro experiments that amino and betaine derivatives can inhibit acetylcholinesterase and butyrylcholinesterase on the level of pyridostigmine while the toxicity of the obtained compounds is much lower than that of pyridostigmine. |
| PubMedSearch : Padnya_2019_Bioorg.Chem__103455 |
| PubMedID: 31791680 |
Padnya PL, Bayarashov EE, Zueva IV, Lushchekina SV, Lenina OA, Evtugyn VG, Osin YN, Petrov KA, Stoikov, II (2019)
Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors
Bioorg Chem
:103455
Padnya PL, Bayarashov EE, Zueva IV, Lushchekina SV, Lenina OA, Evtugyn VG, Osin YN, Petrov KA, Stoikov, II (2019)
Bioorg Chem
:103455