| Title : Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists - Palani_2004_Bioorg.Med.Chem.Lett_14_1791 |
| Author(s) : Palani A , Dugar S , Clader JW , Greenlee WJ , Ruperto V , Duffy RA , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1791 , 2004 |
|
Abstract :
Low molecular weight amide derivatives were synthesized and evaluated as M(2) receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M(2) receptor antagonists with structural features different from our clinical candidate 1. |
| PubMedSearch : Palani_2004_Bioorg.Med.Chem.Lett_14_1791 |
| PubMedID: 15026073 |
Palani A, Dugar S, Clader JW, Greenlee WJ, Ruperto V, Duffy RA, Lachowicz JE (2004)
Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists
Bioorganic & Medicinal Chemistry Lett
14 :1791
Palani A, Dugar S, Clader JW, Greenlee WJ, Ruperto V, Duffy RA, Lachowicz JE (2004)
Bioorganic & Medicinal Chemistry Lett
14 :1791